Zobrazeno 1 - 10 of 20 pro vyhledávání: '"Igor Nudelman"'
1
Akademický článek
Ex vivo treatment with a novel synthetic aminoglycoside NB54 in primary fibroblasts from Rett syndrome patients suppresses MECP2 nonsense mutations.
Autor: Manuela Vecsler, Bruria Ben Zeev, Igor Nudelman, Yair Anikster, Amos J Simon, Ninette Amariglio, Gideon Rechavi, Timor Baasov, Eva Gak
Publikováno v: PLoS ONE, Vol 6, Iss 6, p e20733 (2011)
BACKGROUND: Nonsense mutations in the X-linked methyl CpG-binding protein 2 (MECP2) comprise a significant proportion of causative MECP2 mutations in Rett syndrome (RTT). Naturally occurring aminoglycosides, such as gentamicin, have been shown to ena
Externí odkaz: https://doaj.org/article/445c35a4b9e34e40b8164541835a3108
Zobrazit plný text záznamu
2
Lung targeted liposomes for treating ARDS
Autor: Sivan Arber Raviv, Mohammed Alyan, Egor Egorov, Agam Zano, Moshit Yaskin Harush, Calvin Pieters, Hila Korach-Rechtman, Adi Saadya, Galoz Kaneti, Igor Nudelman, Shai Farkash, Ofri Doppelt Flikshtain, Lucy N. Mekies, Lilach Koren, Yoav Gal, Ella Dor, Janna Shainsky, Jeny Shklover, Yochai Adir, Avi Schroeder
Publikováno v: Journal of Controlled Release
Acute Respiratory Distress Syndrome (ARDS), associated with Covid-19 infections, is characterized by diffuse lung damage, inflammation and alveolar collapse that impairs gas exchange, leading to hypoxemia and patient' mortality rates above 40%. Here,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1898113915eac693b9d4362f01b74446
Zobrazit plný text záznamu
3
Suppression of CFTR premature termination codons and rescue of CFTR protein and function by the synthetic aminoglycoside NB54
Autor: Igor Nudelman, Marina Mazur, Steven M. Rowe, Erik M. Schwiebert, Valery Belakhov, Peter A. Sloane, David M. Bedwell, Jessica A. Buckley-Lanier, Kyle Backer, Li Ping Tang, Zsuzsa Bebok, Timor Baasov
Publikováno v: Journal of Molecular Medicine. 89:1149-1161
Certain aminoglycosides are capable of inducing "translational readthrough" of premature termination codons (PTCs). However, toxicity and relative lack of efficacy deter treatment with clinically available aminoglycosides for genetic diseases caused
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c6049967db2b4aa4d22d364f01098cf
https://doi.org/10.1007/s00109-011-0787-6
Zobrazit plný text záznamu
4
Readthrough of nonsense mutations in Rett syndrome: evaluation of novel aminoglycosides and generation of a new mouse model
Autor: Eike Wegener, Valery Belakhov, Jutta Gärtner, Cornelia Brendel, Peter Huppke, Hauke B. Werner, Timor Baasov, Igor Nudelman
Publikováno v: Journal of Molecular Medicine
Journal of Molecular Medicine (Berlin, Germany)
Thirty-five percent of patients with Rett syndrome carry nonsense mutations in the MECP2 gene. We have recently shown in transfected HeLa cells that readthrough of nonsense mutations in the MECP2 gene can be achieved by treatment with gentamicin and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9cb5d4fa94836b35f27fd6af6986fa0
https://doi.org/10.1007/s00109-010-0704-4
Zobrazit plný text záznamu
5
Development of Novel Aminoglycoside (NB54) with Reduced Toxicity and Enhanced Suppression of Disease-Causing Premature Stop Mutations
Autor: Igor Nudelman, Valery Belakhov, Jochen Schacht, Marina Cherniavsky, Annie Rebibo-Sabbah, Tamar Ben-Yosef, Timor Baasov, Mariana Hainrichson, Fuquan Chen, Daniel S. Pilch
Publikováno v: Journal of Medicinal Chemistry. 52:2836-2845
Nonsense mutations promote premature translational termination and represent the underlying cause of a large number of human genetic diseases. The aminoglycoside antibiotic gentamicin has the ability to allow the mammalian ribosome to read past a fal
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c30fd676734cfc9d565b40ffced6f3d3
https://doi.org/10.1021/jm801640k
Zobrazit plný text záznamu
6
Combined Chemical-Enzymatic Assembly of Aminoglycoside Derivatives with N-1-AHB Side Chain
Autor: Lilach Chen, Igor Nudelman, Jonathan B. Spencer, El-Habib Sahraoui, Marina Cherniavsky, Timor Baasov, Nicholas M. Llewellyn
Publikováno v: Advanced Synthesis & Catalysis. 350:1682-1688
A series of unprotected pseudo-disaccharides and pseudo-trisaccharides of 2-deoxystreptamine-containing aminoglycosides have been selectively acylated at the N-1 position with the valuable (S)-4-amino-2-hydroxybutanoyl (AHB) pharmacophore by using th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a866a0a5946942f332b405c4db6dd309
https://doi.org/10.1002/adsc.200800229
Zobrazit plný text záznamu
7
Differential Selectivity of Natural and Synthetic Aminoglycosides towards the Eukaryotic and Prokaryotic Decoding A Sites
Autor: Dalia Shallom-Shezifi, Mariana Hainrichson, Eric Westhof, Jiro Kondo, Daniel S. Pilch, Timor Baasov, Igor Nudelman, Christopher M. Barbieri
Publikováno v: ChemBioChem
ChemBioChem, Wiley-VCH Verlag, 2007, 8 (14), pp.1700-9. ⟨10.1002/cbic.200700271⟩
International audience; The lack of absolute prokaryotic selectivity of natural antibiotics is widespread and is a significant clinical problem. The use of this disadvantage of aminoglycoside antibiotics for the possible treatment of human genetic di
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55d42ed5e3dea20c6c722b8f4a2876b7
https://doi.org/10.1002/cbic.200700271
Zobrazit plný text záznamu
8
In vitro and ex vivo suppression by aminoglycosides of PCDH15 nonsense mutations underlying type 1 Usher syndrome
Autor: Tamar Ben-Yosef, Timor Baasov, Igor Nudelman, Zubair M. Ahmed, Annie Rebibo-Sabbah
Publikováno v: Human Genetics. 122:373-381
Type 1 Usher syndrome (USH1) is a recessively inherited condition, characterized by profound prelingual deafness, vestibular areflexia, and prepubertal onset of retinitis pigmentosa (RP). While the auditory component of USH1 can be treated by cochlea
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d9e6e643c65dad815380e06dab3a5f4
https://doi.org/10.1007/s00439-007-0410-7
Zobrazit plný text záznamu
9
Redesign of aminoglycosides for treatment of human genetic diseases caused by premature stop mutations
Autor: Timor Baasov, Dalia Shallom-Shezifi, Igor Nudelman, Annie Rebibo-Sabbah, Mariana Hainrichson, Ido Stahl, Tamar Ben-Yosef
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 16:6310-6315
A series of new derivatives of the clinically used aminoglycoside antibiotic paromomycin were designed, synthesized, and their ability to read-through premature stop codon mutations was examined in both in vitro translation system and ex vivo mammali
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d668f2c05addec07f3707bdd82e80cd8
https://doi.org/10.1016/j.bmcl.2006.09.013
Zobrazit plný text záznamu
10
Overexpression and Initial Characterization of the Chromosomal Aminoglycoside 3′- O -Phosphotransferase APH(3′)-IIb from Pseudomonas aeruginosa
Autor: Mariana Hainrichson, Orit Yaniv, Dalia Shallom-Shezifi, Timor Baasov, Sima Yaron, Marina Cherniavsky, Igor Nudelman
Publikováno v: Antimicrobial Agents and Chemotherapy. 51:774-776
The chromosomal gene aph(3 ′ )-IIb , encoding an aminoglycoside 3′-phosphotransferase in Pseudomonas aeruginosa , was cloned and overexpressed in Escherichia coli . The APH(3′)-IIb enzyme was purified as a monomer in a two-step procedure and wa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f14f50711eb8bfa54aa1482ee46c3fbe
https://doi.org/10.1128/aac.01034-06
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje