Zobrazeno 1 - 10
of 152
pro vyhledávání: '"Igor N Berezovsky"'
Publikováno v:
Current Research in Structural Biology, Vol 7, Iss , Pp 100142- (2024)
Binding of nucleotides and their derivatives is one of the most ancient elementary functions dating back to the Origin of Life. We review here the works considering one of the key elements in binding of (di)nucleotide-containing ligands – phosphate
Externí odkaz:
https://doaj.org/article/6d225fb39eab47c59ab5526adbc3bd5d
Publikováno v:
Current Research in Structural Biology, Vol 7, Iss , Pp 100129- (2024)
Since nucleic acids and proteins of unicellular prokaryotes are directly exposed to extreme environmental conditions, it is possible to explore the genomic-proteomic compositional determinants of molecular mechanisms of adaptation developed by them i
Externí odkaz:
https://doaj.org/article/f6b4dd65a97543b2b6ad6d8273b19add
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract We tackle here genomic mechanisms of a rapid onset and recovery from anosmia—a potential diagnostic indicator for early-stage COVID-19 infection. Based on previous observations on how olfactory receptor (OR) gene expression is regulated vi
Externí odkaz:
https://doaj.org/article/ac08d6ea144646a3b93ae2cb6a35f5fb
Publikováno v:
Current Research in Structural Biology, Vol 2, Iss , Pp 191-203 (2020)
Studies of protein allostery increasingly reveal an involvement of the back and forth order-disorder transitions in this mechanism of protein activity regulation. Here, we investigate the allosteric mechanisms mediated by structural disorder using th
Externí odkaz:
https://doaj.org/article/51630aabf736437d861b835a44d1cb4f
Publikováno v:
Nucleic Acids Research. 51:D345-D351
AlloMAPS 2 is an update of the Allosteric Mutation Analysis and Polymorphism of Signalling database, which contains data on allosteric communication obtained for predicted structures in the AlphaFold database (AFDB) and trRosetta-predicted Pfam domai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eda8eaca1dba333c381e7b35f6180a14
https://doi.org/10.1093/nar/gkac828
https://doi.org/10.1093/nar/gkac828
Publikováno v:
PLoS Computational Biology, Vol 14, Iss 12, p e1006686 (2018)
We propose a new computational method for exploring chromatin structural organization based on Markov State Modelling of Hi-C data represented as an interaction network between genomic loci. A Markov process describes the random walk of a traveling p
Externí odkaz:
https://doaj.org/article/bc70ba955f9e48409c54544a03897131
Publikováno v:
PLoS Computational Biology, Vol 14, Iss 6, p e1006228 (2018)
The omnipresence of allosteric regulation together with the fundamental role of structural dynamics in this phenomenon have initiated a great interest to the detection of regulatory exosites and design of corresponding effectors. However, despite a g
Externí odkaz:
https://doaj.org/article/48c65a1011f549a69d12a1aebf0abc0d
We tackle here genomic mechanisms of a rapid onset and recovery from anosmia - a useful diagnostic indicator for early-stage COVID-19 infection. On the basis of earlier observed specifics of olfactory receptors (ORs) regulation in the mice chromatin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db9e270fe7f597602fa312798d818e35
https://doi.org/10.1101/2022.08.19.504545
https://doi.org/10.1101/2022.08.19.504545
Publikováno v:
The Journal of Physical Chemistry B. 125:3763-3780
While the pervasiveness of allostery in proteins is commonly accepted, we further show the generic nature of allosteric mechanisms by analyzing here transmembrane ion-channel viroporin 3a and RNA-dependent RNA polymerase (RdRp) from SARS-CoV-2 along
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06faa607b0ebeaa7ced1e499ff6ff5f9
https://doi.org/10.1021/acs.jpcb.1c00540
https://doi.org/10.1021/acs.jpcb.1c00540
Autor:
Enrico Guarnera, Igor N. Berezovsky
Publikováno v:
The Journal of Chemical Physics. 158:135101
The omnipresence and diversity of allosteric regulation in proteins and protein associations complemented by the potential for the design of allosterically acting biologics and drugs call for the development of a new generation of computational model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::706bcf0507327f852857bca9ae870f4e
https://doi.org/10.1063/5.0139848
https://doi.org/10.1063/5.0139848