Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Igor Makhlin"'
Autor:
Sana Sara Dastgheyb, Kristine Kim, Abigail Doucette, Gary Freedman, Payal Shah, Igor Makhlin, Amy Clark, Neil Taunk
Publikováno v:
Breast, Vol 67, Iss , Pp 26-29 (2023)
Trastuzumab emtansine (T-DM1) is a novel therapeutic for HER2+ breast cancer patients with residual disease after neoadjuvant chemotherapy. Concurrent radiotherapy (RT) is offered to a subset of patients based on results from the KATHERINE trial whic
Externí odkaz:
https://doaj.org/article/0bd82a1546114b07aeb98999053c8f6c
Autor:
Saisai Chen, Matt R. Paul, Christopher J. Sterner, George K. Belka, Dezhen Wang, Peining Xu, Amulya Sreekumar, Tien-chi Pan, Dhruv K. Pant, Igor Makhlin, Angela DeMichele, Clementina Mesaros, Lewis A. Chodosh
Publikováno v:
Breast Cancer Research, Vol 25, Iss 1, Pp 1-20 (2023)
Abstract Background Breast cancer mortality is principally due to recurrent disease that becomes resistant to therapy. We recently identified copy number (CN) gain of the putative membrane progesterone receptor PAQR8 as one of four focal CN alteratio
Externí odkaz:
https://doaj.org/article/c264bed9ee0941cbb0795a4506954132
Autor:
Igor Makhlin, Nicholas P. McAndrew, E. Paul Wileyto, Amy S. Clark, Robin Holmes, Lisa N. Bottalico, Clementina Mesaros, Ian A. Blair, Grace R. Jeschke, Kevin R. Fox, Susan M. Domchek, Jennifer M. Matro, Angela R. Bradbury, Michael D. Feldman, Elizabeth O. Hexner, Jacqueline F. Bromberg, Angela DeMichele
Publikováno v:
npj Breast Cancer, Vol 8, Iss 1, Pp 1-9 (2022)
Abstract Circulating IL-6, an activator of JAK/STAT signaling, is associated with poor prognosis and aromatase inhibitor (AI) resistance in hormone-receptor positive (HR+) breast cancer. Here we report the results of a phase 2 single-arm Simon 2-stag
Externí odkaz:
https://doaj.org/article/735547286a764f31ad3de14024a4e997
Autor:
Michael G. Fradley, Nam H. K. Nguyen, David Madnick, Yiqing Chen, Angela DeMichele, Igor Makhlin, Susan Dent, Benedicte Lefebvre, Joseph Carver, Jenica N. Upshaw, David DeRemer, Bonnie Ky, Avirup Guha, Yan Gong
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 12 (2023)
Background Cyclin‐dependent kinase (CDK) 4 and 6 inhibitors have significantly improved survival in patients with hormone receptor–positive metastatic breast cancer. There are few data regarding the epidemiology of cardiovascular adverse events (
Externí odkaz:
https://doaj.org/article/f73097a8c1484ebdafe65151a6a2f245
Autor:
Igor Makhlin, Ryan D Salinas, Daniel Zhang, Fadi Jacob, Gou-li Ming, Hongjun Song, Deeksha Saxena, Jay F Dorsey, MacLean P Nasrallah, Jennifer JD Morrissette, Zev A Binder, Donald M O'Rourke, Arati S Desai, Steven Brem, Stephen J Bagley
Publikováno v:
CNS Oncology, Vol 8, Iss 3 (2019)
Glioblastoma (GBM) is the most common primary malignant brain tumor in adults and carries a dismal prognosis. The EGFR gene is among the most commonly deranged genes in GBM and thus an important therapeutic target. We report the case of a young femal
Externí odkaz:
https://doaj.org/article/03959e296e524237be76b58b81c7e0c8
Autor:
Tara Kaufmann, Patrick Chang, Shoshana Rosenberg, Elizabeth Frank, Brian Hobbs, Lauren J. Bayne, Isoris Nivar, Brooke L. Goodspeed, Killian M. Rohn, Emily M. Kugler, Kevin Fox, Susan Domchek, Angela Bradbury, Payal Shah, Hayley Knollman, Rachel C. Jankowitz, Igor Makhlin, Amy S. Clark, Lewis A. Chodosh, Angela DeMichele, Katherine Goodfellow
Publikováno v:
Cancer Research. 83:P5-08
Background: Patients treated for early stage breast cancer (BC) have a 30% lifetime risk of developing metastatic disease. Numerous studies have demonstrated that dormant bone marrow disseminated tumor cells (DTCs) are independently associated with r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4488dc09c346aed1b48635e8528aa9f
https://doi.org/10.1158/1538-7445.sabcs22-p5-08-01
https://doi.org/10.1158/1538-7445.sabcs22-p5-08-01
Autor:
Igor Makhlin, Nicholas McAndrew, E. Paul Wileyto, Amy Clark, Robin Holmes, Lisa N Bottalico, Grace R Jeschke, Kevin R Fox, Susan M Domcheck, Jennifer M Matro, Angela R Bradbury, Natalie Shih, Michael D Feldman, Elizabeth O Hexner, Jacqueline F Bromberg, Angela DeMichele
Publikováno v:
Cancer Research. 82:P2-07
Background: Circulating IL-6, an activator of JAK/STAT signaling, is associated with poor outcomes and aromatase inhibitor (AI) resistance in hormone-receptor positive (HR+) metastatic breast cancer (MBC). We previously presented clinical outcomes of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf15d55edbe63918bf187416026f8c41
https://doi.org/10.1158/1538-7445.sabcs21-p2-07-04
https://doi.org/10.1158/1538-7445.sabcs21-p2-07-04
Autor:
Igor Makhlin, Katrina Esther Korhonen, Melissa Lynne Martin, Jennifer Gillman, Erin Schubert, Austin Ryan Pantel, David A. Mankoff, Amy S. Clark
Publikováno v:
Radiol Imaging Cancer
Fluorine 18 ((18)F) fluorodeoxyglucose (FDG) PET/CT has shown promise for use in assessing treatment response in patients with bone-only or bone-dominant (BD) metastatic breast cancer (mBC). In this single-institution, prospective single-arm study of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77e1561b67a10b3fbc579bdc0de5ea3b
https://europepmc.org/articles/PMC9713595/
https://europepmc.org/articles/PMC9713595/
Autor:
Igor Makhlin, Nicholas McAndrew, E. Wileyto, Amy Clark, Robin Holmes, Lisa Bottalico, Clementina Mesaros, Ian Blair, Grace Jeschke, Kevin Fox, Susan Domchek, Jennifer Matro, Angela Bradbury, Michael Feldman, Elizaabeth Hexner, Jacqueline Bromberg, Angela DeMichele
PURPOSE Circulating IL-6, an activator of JAK/STAT signaling, is associated with poor outcomes and aromatase inhibitor (AI) resistance in hormone-receptor positive (HR+) breast cancer. We investigated the safety and efficacy of ruxolitinib, an oral s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c99816ef0606bece0351af0d2cced9d1
https://doi.org/10.21203/rs.3.rs-1623128/v1
https://doi.org/10.21203/rs.3.rs-1623128/v1
Publikováno v:
International Mathematics Research Notices.
We study toric degenerations of semi-infinite Grassmannians (a.k.a. quantum Grassmannians). While the toric degenerations of the classical Grassmannians are well studied, the only known example in the semi-infinite case is due to Sottile and Sturmfel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87b15ff37d761c0df4b11de54dbf899e
https://doi.org/10.1093/imrn/rnac116
https://doi.org/10.1093/imrn/rnac116