Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Igor L. Novak"'
Autor:
Masoud Nickaeen, Igor L Novak, Stephanie Pulford, Aaron Rumack, Jamie Brandon, Boris M Slepchenko, Alex Mogilner
Publikováno v:
PLoS Computational Biology, Vol 13, Iss 11, p e1005862 (2017)
To understand shapes and movements of cells undergoing lamellipodial motility, we systematically explore minimal free-boundary models of actin-myosin contractility consisting of the force-balance and myosin transport equations. The models account for
Externí odkaz:
https://doaj.org/article/f57863f9916041e69d181b2b2efcaa74
Publikováno v:
PLoS Computational Biology, Vol 12, Iss 12, p e1005236 (2016)
Hybrid deterministic-stochastic methods provide an efficient alternative to a fully stochastic treatment of models which include components with disparate levels of stochasticity. However, general-purpose hybrid solvers for spatially resolved simulat
Externí odkaz:
https://doaj.org/article/17fc54b60bec4fea80d043a395347d1d
Autor:
Tatyana Svitkina, Ji Yu, Nadia Efimova, Olena Marchenko, Charles W. Wolgemuth, Vladimir Rodionov, Sulagna Das, Leslie M. Loew, Igor L. Novak
Publikováno v:
Molecular Biology of the Cell
A combination of computational and experimental approaches is used to show that the complex dynamics of dendritic filopodia, which is essential for synaptogenesis, is explained by a conceptually simple interplay among actin retrograde flow, myosin co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f514ec1419ad79d8cd44ba72a3553c0d
https://doi.org/10.1091/mbc.e16-06-0461
https://doi.org/10.1091/mbc.e16-06-0461
Autor:
Alex Mogilner, Aaron Rumack, Stephanie Pulford, Masoud Nickaeen, Igor L. Novak, Jamie Brandon, Boris M. Slepchenko
Publikováno v:
PLoS Computational Biology, Vol 13, Iss 11, p e1005862 (2017)
PLoS Computational Biology
PLoS Computational Biology
To understand shapes and movements of cells undergoing lamellipodial motility, we systematically explore minimal free-boundary models of actin-myosin contractility consisting of the force-balance and myosin transport equations. The models account for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31fc8bec606f02be24a5228a550c5619
http://europepmc.org/articles/PMC5705165?pdf=render
http://europepmc.org/articles/PMC5705165?pdf=render
Autor:
Igor L. Novak, Lev Truskinovsky
Publikováno v:
Mathematics and Mechanics of Solids. 20:697-720
Tetanized muscle myofibrils are often modeled as one-dimensional chains where springs represent half-sarcomeres (HS). The force–length relation for individual HSs (isometric tetanus) is known to have a ‘descending limb’, a segment with an appar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5c36ce957a3b4333307c9fc61c1d959
https://doi.org/10.1177/1081286514551504
https://doi.org/10.1177/1081286514551504
Autor:
Igor L. Novak, Boris M. Slepchenko
Publikováno v:
Journal of Computational Physics. 270:203-213
We describe a novel conservative algorithm for parabolic problems in domains with moving boundaries developed for modeling in cell biology. The spatial discretization is accomplished by applying Voronoi decomposition to a fixed rectangular grid. In t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cde0b18ad5a525fb4d1631aefc8f3c13
https://doi.org/10.1016/j.jcp.2014.03.014
https://doi.org/10.1016/j.jcp.2014.03.014
Autor:
Igor L. Novak, Lev Truskinovsky
Publikováno v:
Philosophical transactions. Series A, Mathematical, physical, and engineering sciences. 375(2093)
The complexity of fracture-induced segmentation in elastically constrained cohesive (fragile) systems originates from the presence of competing interactions. The role of discreteness in such phenomena is of interest in a variety of fields, from hiera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aab98a1be2a46f9d0b04c042181d3fbc
https://pubmed.ncbi.nlm.nih.gov/28373383
https://pubmed.ncbi.nlm.nih.gov/28373383
Publikováno v:
PLoS Computational Biology, Vol 12, Iss 12, p e1005236 (2016)
PLoS Computational Biology
PLoS Computational Biology
Hybrid deterministic-stochastic methods provide an efficient alternative to a fully stochastic treatment of models which include components with disparate levels of stochasticity. However, general-purpose hybrid solvers for spatially resolved simulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cba90267dd032e8c7a258cfa3fe94a5
http://europepmc.org/articles/PMC5154471?pdf=render
http://europepmc.org/articles/PMC5154471?pdf=render
Autor:
Vladimir Rodionov, Nadia Efimova, Leslie M. Loew, Charles W. Wolgemuth, Ji Yu, Olena Marchenko, Igor L. Novak, Sulagna Das, Tatyana Svitkina
Impact StatementIn this study, using a combination of computational and experimental approaches we show that a complex dynamic behavior of dendritic filopodia that is essential for synaptogenesis is explained by an interplay among forces generated by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5993c14593af6652ccd299a5b755ece
https://doi.org/10.1101/057919
https://doi.org/10.1101/057919
Publikováno v:
WIREs Systems Biology and Medicine. 4:129-140
The Virtual Cell (VCell) is a general computational framework for modeling physico-chemical and electrophysiological processes in living cells. Developed by the National Resource for Cell Analysis and Modeling at the University of Connecticut Health
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f103917078e79fec257dae7c36005ac
https://doi.org/10.1002/wsbm.165
https://doi.org/10.1002/wsbm.165