Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Igor L. Barsukov"'
Autor:
Johanna Lilja, Jasmin Kaivola, James R. W. Conway, Joni Vuorio, Hanna Parkkola, Pekka Roivas, Michal Dibus, Megan R. Chastney, Taru Varila, Guillaume Jacquemet, Emilia Peuhu, Emily Wang, Ulla Pentikäinen, Itziar Martinez D. Posada, Hellyeh Hamidi, Arafath K. Najumudeen, Owen J. Sansom, Igor L. Barsukov, Daniel Abankwa, Ilpo Vattulainen, Marko Salmi, Johanna Ivaska
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract The KRAS oncogene drives many common and highly fatal malignancies. These include pancreatic, lung, and colorectal cancer, where various activating KRAS mutations have made the development of KRAS inhibitors difficult. Here we identify the s
Externí odkaz:
https://doaj.org/article/aab4a06c715b4e4481e20d3e6037ab7e
Autor:
Simon Wheeler, Colum Breen, Yong Li, Sarah H. Hewitt, Erin Robertson, Edwin A. Yates, Igor L. Barsukov, David G. Fernig, Stephen J. Butler
Publikováno v:
Organic & Biomolecular Chemistry. 20:596-605
Sulfotransferases constitute a ubiquitous class of enzymes which are poorly understood due to the lack of a convenient tool for screening their activity. These enzymes use the anion PAPS (adenosine-3'-phosphate-5'-phosphosulfate) as a donor for a bro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2c4ba002eddb606bce9281e92068bbd
https://doi.org/10.1039/d1ob02071d
https://doi.org/10.1039/d1ob02071d
Autor:
Johanna Lilja, Jasmin Kaivola, James R.W. Conway, Joni Vuorio, Hanna Parkkola, Pekka Roivas, Taru Varila, Guillaume Jacquemet, Emilia Peuhu, Emily Wang, Ulla Pentikäinen, Itziar Martinez D. Posada, Hellyeh Hamidi, Arafat K. Najumudeen, Owen J. Sansom, Igor L. Barsukov, Daniel Abankwa, Ilpo Vattulainen, Marko Salmi, Johanna Ivaska
The KRAS oncogene drives many common and highly fatal malignancies. These include pancreatic, lung, and colorectal cancer, where numerous different activating KRAS mutations have made the development of KRAS inhibitors difficult. Here we identify the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1cdc8c2c24b8593c2331184d4cf85fce
https://doi.org/10.1101/2022.09.21.508660
https://doi.org/10.1101/2022.09.21.508660
Autor:
Igor L. Barsukov, Eleonora Balloi, David R. Critchley, Rafaella Konstantinou, Suat Peng Neo, Emily C.S. Wang, Hayley M. Bennett, Kath Clark, Jayantha Gunaratne, Paul Atherton, Marina Ptushkina, Edward Manser, Christoph Ballestrem
The formation of healthy tissue involves continuous remodelling of the extracellular matrix (ECM). Whilst it is known that this requires integrin-associated cell-ECM adhesion sites (CMAs) and actomyosin-mediated forces, the underlying mechanisms rema
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6df1a0020b30dad9f45e4f7f3e32c35
https://doi.org/10.1101/2021.07.16.452612
https://doi.org/10.1101/2021.07.16.452612
Autor:
Tibbe D, Wang E, Woike D, Igor L. Barsukov, Larsen M, Hassani Nia F, Kibaek M, Hans-Jürgen Kreienkamp, Fagerberg Cr
Shank proteins are major scaffolds of the postsynaptic density of excitatory synapses. Mutations inSHANKgenes are associated with autism and intellectual disability. The relevance of missense mutations for these pathologies is unclear. Several missen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61b4e98540ee5c609ddf06fcd1c8c999
https://doi.org/10.1101/2021.04.13.439653
https://doi.org/10.1101/2021.04.13.439653
Autor:
Min Du, Igor L. Barsukov, Guozheng Wang, Stephane R. Gross, Philip S. Rudland, Richard A.P. Smith
Publikováno v:
BIOCHEMICAL JOURNAL
Biochemical Journal
Biochemical Journal
Overexpression of S100P promotes breast cancer metastasis in animals and elevated levels in primary breast cancers are associated with poor patient outcomes. S100P can differentially interact with nonmuscle myosin (NM) isoforms (IIA > IIC > IIB) lead
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32ecf3d52ec537d68ef80cada513c174
https://publications.aston.ac.uk/id/eprint/41245/1/BCJ_2019_0644R2_Merged_PDF.pdf
https://publications.aston.ac.uk/id/eprint/41245/1/BCJ_2019_0644R2_Merged_PDF.pdf
Autor:
Igor L. Barsukov, Franziska Lausecker, Christoph Ballestrem, Andrew P. Gilmore, David R. Critchley, Alexandre F. Carisey, Paul Atherton
Publikováno v:
Atherton, P, Lausecker, F, Carisey, A, Gilmore, A, Critchley, D, Barsukov, I & Ballestrem, C 2020, ' Relief of talin autoinhibition triggers a force-independent association with vinculin ', The Journal of cell biology, vol. 219, no. 1 . https://doi.org/10.1083/jcb.201903134
JOURNAL OF CELL BIOLOGY
The Journal of Cell Biology
Atherton, P, Lausecker, F, Carisey, A, Gilmore, A, Critchley, D, Barsukov, I & Ballestrem, C 2019, ' Relief of talin autoinhibition triggers a force-independent association with vinculin ', The Journal of cell biology, vol. 219, no. 1, e201903134, pp. 1-16 . https://doi.org/10.1083/jcb.201903134
JOURNAL OF CELL BIOLOGY
The Journal of Cell Biology
Atherton, P, Lausecker, F, Carisey, A, Gilmore, A, Critchley, D, Barsukov, I & Ballestrem, C 2019, ' Relief of talin autoinhibition triggers a force-independent association with vinculin ', The Journal of cell biology, vol. 219, no. 1, e201903134, pp. 1-16 . https://doi.org/10.1083/jcb.201903134
Talin and vinculin control mechanosensing by linking adhesion receptors to the contractile actin cytoskeleton. Using a mitochondrial targeting system, Atherton et al. elucidate mechanisms regulating conformational changes required for vinculin bindin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6b9e39aa3f56a04f10d008fdc73da8c
https://www.research.manchester.ac.uk/portal/en/publications/relief-of-talin-autoinhibition-triggers-a-forceindependent-association-with-vinculin(bb6e044b-4af7-4453-ae9a-c09b2c22400e).html
https://www.research.manchester.ac.uk/portal/en/publications/relief-of-talin-autoinhibition-triggers-a-forceindependent-association-with-vinculin(bb6e044b-4af7-4453-ae9a-c09b2c22400e).html
Autor:
Giulianna P.V. Andrade, Adriana S. Brito, Igor L. Barsukov, Lais C.G.F. Palhares, Suely F. Chavante, Marcelo A. Lima, Edwin A. Yates, James A. London, Helena B. Nader
The detailed structure of a further Chondroitin Sulfate from Litopenaeus vannamei shrimp (sCS) is described. The backbone structure was established by 1H/13C NMR, which identified 3-O-sulfated GlcA, 4-O-sulfated GalNAc, 6-O-sulfated GalNAc, and 4,6-d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cee41c567e7569a018058418ad045f75
https://eprints.keele.ac.uk/6552/1/1-s2.0-S0144861719306988-main.pdf
https://eprints.keele.ac.uk/6552/1/1-s2.0-S0144861719306988-main.pdf
Autor:
Alexandre F. Carisey, Igor L. Barsukov, David R. Critchley, Andrew P. Gilmore, Paul Atherton, Christoph Ballestrem, Franziska Lausecker
Talin, vinculin and paxillin are core components of the dynamic link between integrins and actomyosin. Here we study the mechanisms that mediate their activation and association using a mitochondrial-targeting assay, structure-based mutants, and adva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bcc7fa5ea7a4a3d755eb415c27c5706
Publikováno v:
Carbohydrate Research. 499:108225
The formation of β-glucuronides is a major route by which mammals detoxify and remove breakdown products, such as l -tyrosine, as well as many xenobiotics, from their systems. In humans, dietary l -tyrosine is broken down largely by the action of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::988cc090e7f022e64b6e7975b4ad6d7b
https://doi.org/10.1016/j.carres.2020.108225
https://doi.org/10.1016/j.carres.2020.108225