Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Igor Ivanisevic"'
Autor:
Igor Ivanisevic, Stephen R. Byrn, David Engers, Jonathan Jimenez-Novoa, Ann Newman, Cheryl Campbell, Philip Gent, John Thomson, Jing Teng, Alison Templeton, Stuart Hossack
Publikováno v:
Journal of Pharmaceutical Sciences. 99:3901-3922
A solid-state approach to enable compounds in preclinical development is used by identifying an amorphous solid dispersion in a simple formulation to increase bioavailability. Itraconazole (ITZ) was chosen as a model crystalline compound displaying p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f331610905bf23b9e4af3173d085fd5f
https://doi.org/10.1002/jps.22233
https://doi.org/10.1002/jps.22233
Publikováno v:
Pharmaceutical Research. 26:2523-2534
To evaluate drug-polymer miscibility behavior in four different drug-polymer amorphous solid dispersion systems, namely felodipine-poly(vinyl pyrrolidone) (PVP), nifedipine-PVP, ketoconazole-PVP, and felodipine-poly(acrylic acid) (PAA).Amorphous soli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdff3dffa26ca1d8501b03a2704e959e
https://doi.org/10.1007/s11095-009-9970-7
https://doi.org/10.1007/s11095-009-9970-7
Publikováno v:
Journal of Pharmaceutical Sciences. 98:3373-3386
A typical approach to miscibility analysis of amorphous drug-excipient dispersions involves measuring the glass transition temperature, Tg, using differential scanning calorimetery (DSC). Recently, we discussed two computational methods for the misci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd0df6bfa853486538b317ccc80f9b3f
https://doi.org/10.1002/jps.21717
https://doi.org/10.1002/jps.21717
Publikováno v:
Journal of Pharmaceutical Sciences. 97:4840-4856
Recognizing limitations with the standard method of determining whether an amorphous API–polymer mixture is miscible based on the number of glass transition temperatures (Tg) using differential scanning calorimetry (DSC) measurements, we have devel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5106013ba9fcfa19ec73d276ba39b5a
https://doi.org/10.1002/jps.21352
https://doi.org/10.1002/jps.21352
Publikováno v:
Journal of Pharmaceutical Sciences. 96:1418-1433
The progressive conversion of crystalline raffinose pentahydrate to its amorphous form by dehydration at 60°C, well below its melting temperature, was monitored by X-ray powder diffraction over a period of 72 h. The presence of defects within the cr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::428f028854b098c06496ba4eb73533c0
https://doi.org/10.1002/jps.20944
https://doi.org/10.1002/jps.20944
Autor:
V. Lumelsky, Igor Ivanisevic
Publikováno v:
IEEE Transactions on Systems, Man and Cybernetics, Part B (Cybernetics). 30:471-484
This paper considers an approach to operator-guided real time motion control of robot arm manipulators that's based on the use of configuration space (C-space). The goal is to improve operator performance in a complex environment with obstacles, In s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ae8c45a892d92681e235373e07711a6
https://doi.org/10.1109/3477.846235
https://doi.org/10.1109/3477.846235
Publikováno v:
Pharmaceutical Sciences Encyclopedia
X-ray diffraction (XRD) has a broad range of applications in various stages of drug development and manufacturing, such as API characterization and identification. API characterization is more commonly applied during drug development while API identi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5cf7317da9f05d8200a3d8c8f9760bae
https://doi.org/10.1002/9780470571224.pse414
https://doi.org/10.1002/9780470571224.pse414
Autor:
Igor Ivanisevic
Publikováno v:
Journal of pharmaceutical sciences. 99(9)
Physical stability of 12 amorphous solid dispersions was evaluated over 9–22 months under ambient conditions using X-ray powder diffraction. The nine dispersions initially characterized as miscible drug-polymer systems all remained X-ray amorphous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf1c1f906f3012bd544d29c50b2d9f11
https://pubmed.ncbi.nlm.nih.gov/20533553
https://pubmed.ncbi.nlm.nih.gov/20533553
Autor:
Michael J. Pikal, Yonglai Yang, Igor Ivanisevic, Adora M. Padilla, Robin H. Bogner, David Engers
Publikováno v:
Journal of pharmaceutical sciences. 100(1)
Phase separation in amorphous freeze-dried mixtures is likely in many systems. However, suitable detection methodology has been lacking, as the classical technique, differential scanning calorimetry (DSC), relies upon detection of multiple glass tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96d2e485dfdcf78d409c8e8610418ddb
https://pubmed.ncbi.nlm.nih.gov/20602453
https://pubmed.ncbi.nlm.nih.gov/20602453
Publikováno v:
The journal of physical chemistry. B. 109(16)
We introduce a novel pattern matching algorithm optimized for X-ray powder diffraction (XRPD) data and useful for data from other types of analytical techniques (e.g., Raman, IR). The algorithm is based on hierarchical clustering with a similarity me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41cc0ade8144e0a85c77fe3ca86d15bf
https://pubmed.ncbi.nlm.nih.gov/16851904
https://pubmed.ncbi.nlm.nih.gov/16851904