Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Igor G. Safonov"'
Autor:
Kristin K. Brown, Jack D. Leber, Sharad K. Verma, Shu-Yun Zhang, Hong Lin, Brian Donovan, Mei Li, Dirk A. Heerding, Elisabeth A. Minthorn, Louis V. LaFrance, Kimberly A. Robell, Barry S. Brown, Juan I. Luengo, Igor G. Safonov, Wenyong Wang, Dennis S. Yamashita, Michael D. Schaber, Dennis T. Takata, Dana S. Levy, Jason A. Kahana, Joseph W. Venslavsky, Jin Zeng, Rakesh Kumar, Ren Xie, Anthony E. Choudhry, Zhihong Lai
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:684-688
The synthesis and evaluation of tetrasubstituted aminopyridines, bearing novel azaindazole hinge binders, as potent AKT inhibitors are described. Compound 14c was identified as a potent AKT inhibitor that demonstrated reduced CYP450 inhibition and an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c35f1d03a41bbaae3c90655ee77ea89d
https://doi.org/10.1016/j.bmcl.2009.11.061
https://doi.org/10.1016/j.bmcl.2009.11.061
Autor:
Dirk A. Heerding, Richard M. Keenan, Christopher B. Hopson, Peter M. Tapley, Jenna L. Levin, Igor G. Safonov, Kenneth A. Lord, Connie L. Erickson-Miller, Price Alan T
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:1212-1216
A novel benzimidazole series of small-molecule thrombopoietin receptor agonists has been discovered. Herein, we discuss the preliminary exploration of structure-activity relationships within this chemotype.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd6babbd732400aa0d28bf26a8092072
https://doi.org/10.1016/j.bmcl.2005.11.096
https://doi.org/10.1016/j.bmcl.2005.11.096
Publikováno v:
Tetrahedron Letters. 38:8133-8136
In the pursuit of a porphyrin-fullerene linked hybrid with increased solubility and superior cation complexation abilities, hybrid 1 was synthesized. The amphiphilic hybrid 1 was found to be slightly soluble in DMSO, displayed a lower affinity for me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a469a070e9f826f59469033824083f0
https://doi.org/10.1016/s0040-4039(97)10184-8
https://doi.org/10.1016/s0040-4039(97)10184-8
Autor:
Amos B. Smith, Igor G. Safonov
Publikováno v:
Organic Letters. 4:635-637
[reaction: see text] The total synthesis of the new cytotoxic marine macrolide (+)-dactylolide (1) has been achieved in nine steps from known vinyl bromide (-)-AB. In addition, (+)-zampanolide (2) has been converted to (+)-dactylolide (1) via thermol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::244c4cdf6dd0b6916e720fdeeca75e03
https://doi.org/10.1021/ol017271e
https://doi.org/10.1021/ol017271e
Publikováno v:
ChemInform. 29
In the pursuit of a porphyrin-fullerene linked hybrid with increased solubility and superior cation complexation abilities, hybrid 1 was synthesized. The amphiphilic hybrid 1 was found to be slightly soluble in DMSO, displayed a lower affinity for me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fead2621ae26f1dcb62a5f1dc4145f57
https://doi.org/10.1002/chin.199807131
https://doi.org/10.1002/chin.199807131
Autor:
David I. Schuster, Shaun MacMahon, Phil S. Baran, Stephen R. Wilson, Igor G. Safonov, Robert Fong
Publikováno v:
ChemInform. 32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::949f38f538f0a9fbd1d08b50977257fd
https://doi.org/10.1002/chin.200146097
https://doi.org/10.1002/chin.200146097
Autor:
Igor G. Safonov, Amos B. Smith
Publikováno v:
ChemInform. 33
The total synthesis of the new cytotoxic marine macrolide (+)-dactylolide (1) has been achieved in nine steps from known vinyl bromide (−)-AB. In addition, (+)-zampanolide (2) has been converted to...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48e587ac21321a0e41e885cdcef082c9
https://doi.org/10.1002/chin.200225154
https://doi.org/10.1002/chin.200225154
Publikováno v:
ChemInform. 33
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e131f14f466012ab9a11ebdd2a173b75
https://doi.org/10.1002/chin.200221181
https://doi.org/10.1002/chin.200221181
Autor:
Anthony E. Choudhry, Igor G. Safonov, Dirk A. Heerding, Jack D. Leber, Nelson Rhodes, Susan L. Strum, Mei Li, Michael D. Schaber, Peter J. Tummino, Derek J. Eberwein, Victoria B. Knick, Louis V. LaFrance, Robert A. Copeland, Timothy J. Lansing, Derek R. Duckett, Edgar R. Wood, Richard M. Keenan, Gregory L. Warren, Zhihong Lai, Joseph W. Venslavsky, Randy T. McConnell, Dennis S. Yamashita, Dennis T. Takata, Nestor O. Concha, Rakesh Kumar, Elisabeth A. Minthorn, Tammy J. Clark, Shu-Yun Zhang
Publikováno v:
Journal of medicinal chemistry. 51(18)
Overexpression of AKT has an antiapoptotic effect in many cell types, and expression of dominant negative AKT blocks the ability of a variety of growth factors to promote survival. Therefore, inhibitors of AKT kinase activity might be useful as monot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d22722cf2546163a2efc390d4dfb029c
https://pubmed.ncbi.nlm.nih.gov/18800763
https://pubmed.ncbi.nlm.nih.gov/18800763
Publikováno v:
Annual Reports in Medicinal Chemistry Volume 42 ISBN: 9780123739124
Publisher Summary This chapter discusses small molecule inhibitors of AKT/PKB kinase as a strategy for treating cancer. In studies the 2-pyrimidyl-5-amidothiophene has been identified as an ATP-competitive AKT inhibitor. Also the AKT activity of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dcf242b60890806767f53f8db641bc1f
https://doi.org/10.1016/s0065-7743(07)42023-1
https://doi.org/10.1016/s0065-7743(07)42023-1
