Zobrazeno 1 - 10
of 107
pro vyhledávání: '"Igor E Brodsky"'
Autor:
Daniel C Akuma, Kimberly A Wodzanowski, Ronit Schwartz Wertman, Patrick M Exconde, Víctor R Vázquez Marrero, Chukwuma E Odunze, Daniel Grubaugh, Sunny Shin, Cornelius Taabazuing, Igor E Brodsky
Publikováno v:
eLife, Vol 13 (2024)
Inflammatory caspases are cysteine protease zymogens whose activation following infection or cellular damage occurs within supramolecular organizing centers (SMOCs) known as inflammasomes. Inflammasomes recruit caspases to undergo proximity-induced a
Externí odkaz:
https://doaj.org/article/9a7de7c6836d438db9bfd14207873e03
Publikováno v:
PLoS Pathogens, Vol 19, Iss 6, p e1010767 (2023)
The inflammatory cytokine tumor necrosis factor (TNF) is necessary for host defense against many intracellular pathogens, including Legionella pneumophila. Legionella causes the severe pneumonia Legionnaires' disease and predominantly affects individ
Externí odkaz:
https://doaj.org/article/08fb8a122725426ab65a91afd75c952a
Autor:
Nawar Naseer, Marisa S Egan, Valeria M Reyes Ruiz, William P Scott, Emma N Hunter, Tabitha Demissie, Isabella Rauch, Igor E Brodsky, Sunny Shin
Publikováno v:
PLoS Pathogens, Vol 18, Iss 1, p e1009718 (2022)
Salmonella enterica serovar Typhimurium is a Gram-negative pathogen that uses two distinct type III secretion systems (T3SSs), termed Salmonella pathogenicity island (SPI)-1 and SPI-2, to deliver virulence factors into the host cell. The SPI-1 T3SS e
Externí odkaz:
https://doaj.org/article/6b598c8d660a4ecbb24d13321796015b
Autor:
Elisabet Bjanes, Reyna Garcia Sillas, Rina Matsuda, Benjamin Demarco, Timothée Fettrelet, Alexandra A DeLaney, Opher S Kornfeld, Bettina L Lee, Eric M Rodríguez López, Daniel Grubaugh, Meghan A Wynosky-Dolfi, Naomi H Philip, Elise Krespan, Dorothy Tovar, Leonel Joannas, Daniel P Beiting, Jorge Henao-Mejia, Brian C Schaefer, Kaiwen W Chen, Petr Broz, Igor E Brodsky
Publikováno v:
PLoS Pathogens, Vol 17, Iss 10, p e1009967 (2021)
Cell death plays a critical role in inflammatory responses. During pyroptosis, inflammatory caspases cleave Gasdermin D (GSDMD) to release an N-terminal fragment that generates plasma membrane pores that mediate cell lysis and IL-1 cytokine release.
Externí odkaz:
https://doaj.org/article/8d9976e5a9e54adc98393333ee0b5aa5
Autor:
Adriana R Mantegazza, Meghan A Wynosky-Dolfi, Cierra N Casson, Ariel J Lefkovith, Sunny Shin, Igor E Brodsky, Michael S Marks
Publikováno v:
PLoS Pathogens, Vol 13, Iss 12, p e1006785 (2017)
Bacterial pathogens that compromise phagosomal membranes stimulate inflammasome assembly in the cytosol, but the molecular mechanisms by which membrane dynamics regulate inflammasome activity are poorly characterized. We show that in murine dendritic
Externí odkaz:
https://doaj.org/article/a5393564b7f14e059427fb46cb885d79
Autor:
Fernanda O Novais, Augusto M Carvalho, Megan L Clark, Lucas P Carvalho, Daniel P Beiting, Igor E Brodsky, Edgar M Carvalho, Phillip Scott
Publikováno v:
PLoS Pathogens, Vol 13, Iss 2, p e1006196 (2017)
Deregulated CD8+ T cell cytotoxicity plays a central role in enhancing disease severity in several conditions. However, we have little understanding of the mechanisms by which immunopathology develops as a consequence of cytotoxicity. Using murine mo
Externí odkaz:
https://doaj.org/article/bf659d3cfad341d093c22b1295c01163
Autor:
Naomi H Philip, Alexandra DeLaney, Lance W Peterson, Melanie Santos-Marrero, Jennifer T Grier, Yan Sun, Meghan A Wynosky-Dolfi, Erin E Zwack, Baofeng Hu, Tayla M Olsen, Anthony Rongvaux, Scott D Pope, Carolina B López, Andrew Oberst, Daniel P Beiting, Jorge Henao-Mejia, Igor E Brodsky
Publikováno v:
PLoS Pathogens, Vol 12, Iss 10, p e1005910 (2016)
Caspases regulate cell death programs in response to environmental stresses, including infection and inflammation, and are therefore critical for the proper operation of the mammalian immune system. Caspase-8 is necessary for optimal production of in
Externí odkaz:
https://doaj.org/article/f64d18916f2d4f71922dc3bc9241243c
Autor:
Daniel P Beiting, Lucia Peixoto, Natalia S Akopyants, Stephen M Beverley, E John Wherry, David A Christian, Christopher A Hunter, Igor E Brodsky, David S Roos
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e88398 (2014)
The closely related protozoan parasites Toxoplasma gondii and Neospora caninum display similar life cycles, subcellular ultrastructure, invasion mechanisms, metabolic pathways, and genome organization, but differ in their host range and disease patho
Externí odkaz:
https://doaj.org/article/a5230609c1094dafa055494f4eedb004
Autor:
Cierra N Casson, Alan M Copenhaver, Erin E Zwack, Hieu T Nguyen, Till Strowig, Bahar Javdan, William P Bradley, Thomas C Fung, Richard A Flavell, Igor E Brodsky, Sunny Shin
Publikováno v:
PLoS Pathogens, Vol 9, Iss 6, p e1003400 (2013)
Inflammasome activation is important for antimicrobial defense because it induces cell death and regulates the secretion of IL-1 family cytokines, which play a critical role in inflammatory responses. The inflammasome activates caspase-1 to process a
Externí odkaz:
https://doaj.org/article/6e70af77061a43699f1f4317eb5ba2ba
Autor:
Ying Zheng, Sarit Lilo, Igor E Brodsky, Yue Zhang, Ruslan Medzhitov, Kenneth B Marcu, James B Bliska
Publikováno v:
PLoS Pathogens, Vol 7, Iss 4, p e1002026 (2011)
A type III secretion system (T3SS) in pathogenic Yersinia species functions to translocate Yop effectors, which modulate cytokine production and regulate cell death in macrophages. Distinct pathways of T3SS-dependent cell death and caspase-1 activati
Externí odkaz:
https://doaj.org/article/07a1861ffb6f4fc885f2d56e48df4a53