Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Igor Dovgan"'
Autor:
Victor Lehot, Ondřej Lidický, Julien Most, Stéphane Erb, Igor Dovgan, Artem Osypenko, Oleksandr Koniev, Sergii Kolodych, Lenka Kotrchová, Guilhem Chaubet, Sarah Cianférani, Tomáš Etrych, Alain Wagner
Publikováno v:
ACS Omega, Vol 8, Iss 43, Pp 40508-40516 (2023)
Externí odkaz:
https://doaj.org/article/61547958d4c8422b851129ddc858ab8c
Autor:
Victor Lehot, Patrick Neuberg, Manon Ripoll, François Daubeuf, Stéphane Erb, Igor Dovgan, Sylvain Ursuegui, Sarah Cianférani, Antoine Kichler, Guilhem Chaubet, Alain Wagner
Publikováno v:
Pharmaceutics, Vol 15, Iss 6, p 1643 (2023)
Despite their clinical success, Antibody-Drug Conjugates (ADCs) are still limited to the delivery of a handful of cytotoxic small-molecule payloads. Adaptation of this successful format to the delivery of alternative types of cytotoxic payloads is of
Externí odkaz:
https://doaj.org/article/3b1c23f633864d7a9b898ed3a61b0eff
Autor:
Wagner, Victor Lehot, Patrick Neuberg, Manon Ripoll, François Daubeuf, Stéphane Erb, Igor Dovgan, Sylvain Ursuegui, Sarah Cianférani, Antoine Kichler, Guilhem Chaubet, Alain
Publikováno v:
Pharmaceutics; Volume 15; Issue 6; Pages: 1643
Despite their clinical success, Antibody-Drug Conjugates (ADCs) are still limited to the delivery of a handful of cytotoxic small-molecule payloads. Adaptation of this successful format to the delivery of alternative types of cytotoxic payloads is of
Antibodies have long been recognized as clinically relevant biomarkers of disease. The onset of a disease often stimulates antibody production at low quantities, making it crucial to develop sensitive, specific, and easy-to-use antibody assay platfor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3accab86dd5ae3fdf2f1cdb23036671
https://doi.org/10.26434/chemrxiv-2023-lm9td
https://doi.org/10.26434/chemrxiv-2023-lm9td
Autor:
Igor Dovgan, Marc Nothisen, Michel Mosser, Guilhem Chaubet, Alain Wagner, Stéphane Erb, Tony Rady, Sarah Cianférani
Publikováno v:
RSC Advances. 11:36777-36780
Bicyclo[6.1.0]non-4-yn-9-ylmethanol (BCN alcohol) is the most prominent strained-alkyne scaffold in chemical biology. Described herein is the synthesis of an oxidized analogue – BCN acid – whose facile functionalization via amide bond formation y
Autor:
Alain Wagner, Steve Hessmann, Charlotte Sornay, Stéphane Erb, Guilhem Chaubet, Igor Dovgan, Thomas Botzanowski, Anthony Ehkirch, Sarah Cianférani
Publikováno v:
Chemistry-A European Journal
Chemistry-A European Journal, Wiley-VCH Verlag, 2020, 26 (61), pp.13797-13805. ⟨10.1002/chem.202002432⟩
Chemistry-A European Journal, Wiley-VCH Verlag, 2020, ⟨10.1002/chem.202002432⟩
Chemistry-A European Journal, Wiley-VCH Verlag, 2020, 26 (61), pp.13797-13805. ⟨10.1002/chem.202002432⟩
Chemistry-A European Journal, Wiley-VCH Verlag, 2020, ⟨10.1002/chem.202002432⟩
International audience; Site-selective modification of proteins has been the object of intense studies over the past decades, especially in the therapeutic field. Prominent results have been obtained with recombinant proteins, for which site-specific
Autor:
Stéphane Erb, Alain Wagner, Sarah Cianférani, Guilhem Chaubet, Igor Dovgan, Charlotte Sornay, Anthony Ehkirch, Thomas Botzanowski, Steve Hessmann
Publikováno v:
Chemistry – A European Journal. 26
Autor:
Alexandre Hentz, Margaux Riomet, Sébastien Delacroix, Oleksandr Koniev, Anthony Ehkirch, Sylvain Ursuegui, Igor Dovgan, Steve Hessmann, Alain Wagner, Frédéric Taran, Sergii Kolodych, Sarah Cianférani
Publikováno v:
Chemical Science
Chemical Science, The Royal Society of Chemistry, 2020, 11 (5), pp.1210-1215. ⟨10.1039/c9sc05468e⟩
Chemical Science, 2020, 11 (5), pp.1210-1215. ⟨10.1039/c9sc05468e⟩
Chemical Science, The Royal Society of Chemistry, 2020, 11 (5), pp.1210-1215. ⟨10.1039/c9sc05468e⟩
Chemical Science, 2020, 11 (5), pp.1210-1215. ⟨10.1039/c9sc05468e⟩
Controlled protein functionalization holds great promise for a wide variety of applications. However, despite intensive research, the stoichiometry of the functionalization reaction remains difficult to control due to the inherent stochasticity of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31bf58838833fe846bc28076937a26d7
https://hal.archives-ouvertes.fr/hal-03012248
https://hal.archives-ouvertes.fr/hal-03012248
On the use of DNA as a linker in antibody-drug conjugates: synthesis, stability and in vitro potency
Autor:
Oleksandr Koniev, Sylvain Ursuegui, Igor Dovgan, Marc Nothisen, Manon Ripoll, Sergii Kolodych, Isabelle Kuhn, Alain Wagner, Sarah Cianférani, Alexandre Hentz, Anthony Ehkirch, Victor Lehot
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Scientific Reports
Scientific Reports, Nature Publishing Group, 2020, 10 (1), ⟨10.1038/s41598-020-64518-y⟩
Scientific Reports
Scientific Reports, Nature Publishing Group, 2020, 10 (1), ⟨10.1038/s41598-020-64518-y⟩
Here we present the synthesis and evaluation of antibody-drug conjugates (ADCs), for which antibody and drug are non-covalently connected using complementary DNA linkers. These ADCs are composed of trastuzumab, an antibody targeting HER2 receptors ov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3a76953282b6adc6deb41770f2169ee
Autor:
Igor Dovgan, Christian D. Muller, Alain Wagner, Sylvain Ursuegui, Steve Hessmann, Chloé Michel, Stéphane Erb, Guilhem Chaubet, Sarah Cianférani
Publikováno v:
Organic and Biomolecular Chemistry
Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2018, 16 (8), pp.1305-1311. ⟨10.1039/c7ob02844j⟩
Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2018, 16 (8), pp.1305-1311. ⟨10.1039/c7ob02844j⟩
International audience; Here, we introduce 4-azidophenyl glyoxal (APG) as an efficient plug-and-play reagent for the selective functionalisation of arginine residues in native antibodies. The selective reaction between APG and arginines’ guanidine