Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Igor D. Zlotnikov"'
Publikováno v:
Biophysica, Vol 4, Iss 3, Pp 340-356 (2024)
Herein, we propose an analytical approach based on intermolecular fluorescent resonant energy transfer (FRET) pairs for the visualization of specific enzyme activity in model biomembranes and in living cells. Cell visualizations with fluorescent conf
Externí odkaz:
https://doaj.org/article/98d09e16cee84d878a1f02b8ad59e50b
Publikováno v:
Gels, Vol 10, Iss 9, p 567 (2024)
Rhodamine 6G (R6G) and 4-nitro-2,1,3-benzoxadiazole (NBD) linked through a spacer molecule spermidine (spd), R6G-spd-NBD, produces a fluorescent probe with pH-sensitive FRET (Förster (fluorescence) resonance energy transfer) effect that can be usefu
Externí odkaz:
https://doaj.org/article/f359d958e6354409a11d19b365db4410
Publikováno v:
Pharmaceutics, Vol 16, Iss 8, p 1007 (2024)
Cancer cells are known to create an acidic microenvironment (the Warburg effect). At the same time, fluorescent dyes can be sensitive to pH, showing a sharp increase or decrease in fluorescence depending on pH. However, modern applications, such as c
Externí odkaz:
https://doaj.org/article/be4e0af2a6764a35b46086111359d14a
Publikováno v:
Polymers, Vol 16, Iss 15, p 2132 (2024)
L-asparaginases (ASP) and Doxorubicin (Dox) are both used in the treatment of leukemia, including in combination. We have attempted to investigate if their combination within the same targeted delivery vehicle can make such therapy more efficacious.
Externí odkaz:
https://doaj.org/article/0136b1e8622e4219ab56440477dd3abd
Publikováno v:
Polymers, Vol 16, Iss 6, p 739 (2024)
Förster resonance energy transfer (FRET) probes are a promising tool for studying numerous biochemical processes. In this paper, we show the application of the FRET phenomenon to observe the micelle formation from surfactants, micelles self-assembli
Externí odkaz:
https://doaj.org/article/98fa2e87535e4db898f2d824dabebe3a
Publikováno v:
Gels, Vol 10, Iss 3, p 157 (2024)
We have developed a micellar formulation of anticancer drugs based on chitosan and heparin grafted with lipoic and oleic acids that can release the cytotoxic cargo (doxorubicin) in response to external stimuli, such as increased glutathione concentra
Externí odkaz:
https://doaj.org/article/69bd1d1047674d39ac46270001b94699
Autor:
Igor D. Zlotnikov, Sergey S. Krylov, Marina N. Semenova, Victor V. Semenov, Elena V. Kudryashova
Publikováno v:
Pharmaceuticals, Vol 16, Iss 12, p 1651 (2023)
Allylbenzenes (apiol, dillapiol, myristicin and allyltetramethoxybenzene) are individual components of plant essential oils that demonstrate antitumor activity and can enhance the antitumor activity of cytotoxic drugs, such as paclitaxel, doxorubicin
Externí odkaz:
https://doaj.org/article/beb66cf681ff46bbbf9adc957cf534f6
Publikováno v:
Biomimetics, Vol 8, Iss 7, p 543 (2023)
The concept of targeted drug delivery can be described in terms of the drug systems’ ability to mimic the biological objects’ property to localize to target cells or tissues. For example, drug delivery systems based on red blood cells or mimickin
Externí odkaz:
https://doaj.org/article/7584ba891134440ab4a57b9ac2d924bb
Publikováno v:
Biomedicines, Vol 11, Iss 10, p 2769 (2023)
Progress in macrophage research is crucial for numerous applications in medicine, including cancer and infectious diseases. However, the existing methods to manipulate living macrophages are labor-intense and inconvenient. Here, we show that macropha
Externí odkaz:
https://doaj.org/article/33a1395dced74358a322d7b2416d15bd
Publikováno v:
Pharmaceutics, Vol 15, Iss 9, p 2353 (2023)
Bacterial infections are usually found in the stomach and the first part of the small intestine in association with various pathologies, including ulcers, inflammatory diseases, and sometimes cancer. Treatment options may include combinations of anti
Externí odkaz:
https://doaj.org/article/dbca2de0c598427599d4b44a6dc444ee