Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Igor Cima"'
Autor:
Vivien Ullrich, Sarah Ertmer, Anna Baginska, Madeleine Dorsch, Hanah H. Gull, Igor Cima, Pia Berger, Celia Dobersalske, Sarah Langer, Loona Meyer, Philip Dujardin, Sied Kebir, Martin Glas, Tobias Blau, Kathy Keyvani, Laurèl Rauschenbach, Ulrich Sure, Alexander Roesch, Barbara M. Grüner, Björn Scheffler
Publikováno v:
iScience, Vol 27, Iss 1, Pp 108596- (2024)
Summary: Adaptive plasticity to the standard chemotherapeutic temozolomide (TMZ) leads to glioblastoma progression. Here, we examine early stages of this process in patient-derived cellular models, exposing the human lysine-specific demethylase 5B (K
Externí odkaz:
https://doaj.org/article/de837c3bce3d4267b86e9e795b2ebef0
Autor:
Phyllis F. Cheung, JiaJin Yang, Rui Fang, Arianna Borgers, Kirsten Krengel, Anne Stoffel, Kristina Althoff, Chi Wai Yip, Elaine H. L. Siu, Linda W. C. Ng, Karl S. Lang, Lamin B. Cham, Daniel R. Engel, Camille Soun, Igor Cima, Björn Scheffler, Jana K. Striefler, Marianne Sinn, Marcus Bahra, Uwe Pelzer, Helmut Oettle, Peter Markus, Esther M. M. Smeets, Erik H. J. G. Aarntzen, Konstantinos Savvatakis, Sven-Thorsten Liffers, Smiths S. Lueong, Christian Neander, Anna Bazarna, Xin Zhang, Annette Paschen, Howard C. Crawford, Anthony W. H. Chan, Siu Tim Cheung, Jens T. Siveke
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Immune responses to pancreatic ductal adenocarcinoma can be inhibited by cancer cells. Here the authors show that high levels of progranulin in PDAC inhibits immune responses by reducing MHC class I antigen presentation through enhanced degradation o
Externí odkaz:
https://doaj.org/article/c9aa189db2194c2eba13f30f461a6fdd
Autor:
I-Na Lu, Celia Dobersalske, Laurèl Rauschenbach, Sarah Teuber-Hanselmann, Anita Steinbach, Vivien Ullrich, Shruthi Prasad, Tobias Blau, Sied Kebir, Jens T. Siveke, Jürgen C. Becker, Ulrich Sure, Martin Glas, Björn Scheffler, Igor Cima
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
A deeper knowledge of the immune cell profile within the brain cancer tumor microenvironment (TM) could identify targets to improve immunotherapy efficacy. Here, in glioblastoma, the authors find haematopoietic stem and progenitor cells in the TM, wh
Externí odkaz:
https://doaj.org/article/7f808554a9294259b8143c4fd9d3ca8b
Publikováno v:
Micromachines, Vol 11, Iss 5, p 486 (2020)
Deformability is shown to correlate with the invasiveness and metastasis of cancer cells. Recent studies suggest epithelial-to-mesenchymal transition (EMT) might enable cancer metastasis. However, the correlation of EMT with cancer cell deformability
Externí odkaz:
https://doaj.org/article/5fb901459630496cb2d431fee06dac86
Autor:
Gunther Boysen, Damaris Bausch-Fluck, Claudio R. Thoma, Anna M. Nowicka, Daniel P. Stiehl, Igor Cima, Van-Duc Luu, Adriana von Teichman, Thomas Hermanns, Tullio Sulser, Barbara Ingold-Heppner, Niklaus Fankhauser, Roland H. Wenger, Wilhelm Krek, Peter Krek, Bernd Wollscheid, Holger Moch
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 14, Iss 6, Pp 535-546 (2012)
Externí odkaz:
https://doaj.org/article/e15cb2f3daa24e03aafef3f77d37c240
Publikováno v:
Cancer Informatics, Vol 2012, Iss 11, Pp 139-146 (2012)
Externí odkaz:
https://doaj.org/article/9d9b156e156c46dd870ce52c7e75fc55
Autor:
Björn Scheffler, Martin Glas, Matthias Simon, Oliver Brüstle, Ulrich Sure, Michael Weller, Guido Reifenberger, Jörg Felsberg, Torsten Pietsch, Frank K.H. van Landeghem, Kathy Keyvani, Tobias Blau, Christel Herold-Mende, Jens T. Siveke, Alexander Roesch, Barbara M. Grüner, Marc Remke, Verena Jendrossek, Johann Matschke, Shruthi Prasad, Igor Cima, Holger Fröhlich, Ashar Ahmad, Timo Wilhelm-Buchstab, Anja Wieland, Franziska K. Lorbeer, Andreas Till, Daniel Trageser, Laurèl Rauschenbach, Sarah Langer, Celia Dobersalske, Pia Berger, Vivien Ullrich, Sied Kebir
Extended Data relating to Main Figure 3/AKT-driven progression of ALDH1A1+ cells in glioblastoma. A, Flow cytometry histograms showing ALDH1A1 expression in the paired treatment-naive vs. clinical relapse patient samples quantified in main Fig. 3A. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::015c1ca113ad006a8dc6af892729aae8
https://doi.org/10.1158/1078-0432.22488669.v1
https://doi.org/10.1158/1078-0432.22488669.v1
Autor:
Björn Scheffler, Martin Glas, Matthias Simon, Oliver Brüstle, Ulrich Sure, Michael Weller, Guido Reifenberger, Jörg Felsberg, Torsten Pietsch, Frank K.H. van Landeghem, Kathy Keyvani, Tobias Blau, Christel Herold-Mende, Jens T. Siveke, Alexander Roesch, Barbara M. Grüner, Marc Remke, Verena Jendrossek, Johann Matschke, Shruthi Prasad, Igor Cima, Holger Fröhlich, Ashar Ahmad, Timo Wilhelm-Buchstab, Anja Wieland, Franziska K. Lorbeer, Andreas Till, Daniel Trageser, Laurèl Rauschenbach, Sarah Langer, Celia Dobersalske, Pia Berger, Vivien Ullrich, Sied Kebir
Purpose:Therapy resistance and fatal disease progression in glioblastoma are thought to result from the dynamics of intra-tumor heterogeneity. This study aimed at identifying and molecularly targeting tumor cells that can survive, adapt, and subclona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a9b80ef2c400c9da401843e9c7ab77e
https://doi.org/10.1158/1078-0432.c.6532785.v1
https://doi.org/10.1158/1078-0432.c.6532785.v1
Autor:
Björn Scheffler, Martin Glas, Matthias Simon, Oliver Brüstle, Ulrich Sure, Michael Weller, Guido Reifenberger, Jörg Felsberg, Torsten Pietsch, Frank K.H. van Landeghem, Kathy Keyvani, Tobias Blau, Christel Herold-Mende, Jens T. Siveke, Alexander Roesch, Barbara M. Grüner, Marc Remke, Verena Jendrossek, Johann Matschke, Shruthi Prasad, Igor Cima, Holger Fröhlich, Ashar Ahmad, Timo Wilhelm-Buchstab, Anja Wieland, Franziska K. Lorbeer, Andreas Till, Daniel Trageser, Laurèl Rauschenbach, Sarah Langer, Celia Dobersalske, Pia Berger, Vivien Ullrich, Sied Kebir
Supplementary Table S1. Discovery cohort of vital cells; Supplementary Table S2. Validation cohort/FFPE tissue samples; Supplementary Table S3. Differentially regulated genes; Supplementary Table S4. Selected gene variants compared between the paired
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e5ab1d0ad14d5a04bcb82db00cfa490
https://doi.org/10.1158/1078-0432.22488663.v1
https://doi.org/10.1158/1078-0432.22488663.v1
Autor:
Sied Kebir, Vivien Ullrich, Pia Berger, Celia Dobersalske, Sarah Langer, Laurèl Rauschenbach, Daniel Trageser, Andreas Till, Franziska K. Lorbeer, Anja Wieland, Timo Wilhelm-Buchstab, Ashar Ahmad, Holger Fröhlich, Igor Cima, Shruthi Prasad, Johann Matschke, Verena Jendrossek, Marc Remke, Barbara M. Grüner, Alexander Roesch, Jens T. Siveke, Christel Herold-Mende, Tobias Blau, Kathy Keyvani, Frank K.H. van Landeghem, Torsten Pietsch, Jörg Felsberg, Guido Reifenberger, Michael Weller, Ulrich Sure, Oliver Brüstle, Matthias Simon, Martin Glas, Björn Scheffler
Purpose: Therapy resistance and fatal disease progression in glioblastoma are thought to result from the dynamics of intra-tumor heterogeneity. This study aimed at identifying and molecularly targeting tumor cells that can survive, adapt, and subclon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c913a94b5d8fd2a3f93514a9381f3196
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85146365389
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85146365389