Kinetic and equilibrium mechanisms of substrate binding to Mycobacterium tuberculosis enoyl reductase: implications to function-based antitubercular agent design

Autor: Igor B. Vasconcelos, Luiz Augusto Basso, Diógenes Santiago Santos

Publikováno v: Journal of the Brazilian Chemical Society, Volume: 21, Issue: 8, Pages: 1503-1508, Published: 2010
Journal of the Brazilian Chemical Society v.21 n.8 2010
Journal of the Brazilian Chemical Society
Sociedade Brasileira de Química (SBQ)
instacron:SBQ

Tuberculosis (TB) remains the leading cause of mortality due to a single bacterial pathogen, Mycobacterium tuberculosis. There is a need for the development of new antimycobacterial agents. M. tuberculosis 2-trans-enoyl-ACP(CoA) reductase (InhA) is t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::219de2993829410b0762bf667898d678
https://doi.org/10.1590/s0103-50532010000800014

New Sensitive Fluorophores for Selective DNA Detection

Autor: Alexandre A. M. Lapis, Diógenes Santiago Santos, Igor B. Vasconcelos, Caroline Thum, Brenno A. D. Neto, Luiz Augusto Basso, Fabiana S. Mancilha, Jairton Dupont

Publikováno v: Organic Letters. 9:4001-4004

4,7-Disubstituted benzothiadiazoles containing 1-arylethynyl and 4-methoxyphenyl groups are selective photoluminescent "light up" probes to duplex DNA with unprecedented sensibility in both spectrophotometric and spectrofluorimetric measurements.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2909430c8cd2df99a98089af437a33bd
https://doi.org/10.1021/ol701708y

Phosphate closes the solution structure of the 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) from Mycobacterium tuberculosis

Autor: Igor B. Vasconcelos, Mario Sergio Palma, J.R. Olivieri, Carlos H.I. Ramos, Giovanni César Santos, Diógenes Santiago Santos, Jose Henrique Pereira, Luiz Augusto Basso, Júlio César Borges, Walter Filgueira de Azevedo

Publikováno v: Archives of Biochemistry and Biophysics. 452:156-164

The 5-enolpyruvylshikimate-3-phosphate synthase catalyses the sixth step of the shikimate pathway that is responsible for synthesizing aromatic compounds and is absent in mammals, which makes it a potential target for drugs development against microb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d7595515fbb7a64fa72187699b65072
https://doi.org/10.1016/j.abb.2006.05.008

Enoyl reductases as targets for the development of anti-tubercular and anti-malarial agents

Autor: Ícaro de Sousa Moreira, Jaim S. Oliveira, D.S. Santos, Luiz Augusto Basso, Igor B. Vasconcelos

Publikováno v: Current drug targets. 8(3)

Tuberculosis (TB) and Malaria are neglected diseases, which continue to be major causes of morbidity and mortality worldwide, killing together around 5 million people each year. Mycolic acids, the hallmark of mycobacteria, are high-molecular-weight a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a7877779e8d49393f87ce85a0a6e461
https://pubmed.ncbi.nlm.nih.gov/17348833

Effects of the magnesium and chloride ions and shikimate on the structure of shikimate kinase from Mycobacterium tuberculosis

Autor: Igor B. Vasconcelos, Diógenes Santiago Santos, Lívia Maria Faim, Luiz Augusto Basso, Walter Filgueira de Azevedo, Marcio Vinicius Bertacine Dias, Jaim S. Oliveira

Publikováno v: Acta crystallographica. Section F, Structural biology and crystallization communications. 63(Pt 1)

Bacteria, fungi and plants can convert carbohydrate and phosphoenolpyruvate into chorismate, which is the precursor of various aromatic compounds. The seven enzymes of the shikimate pathway are responsible for this conversion. Shikimate kinase (SK) i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::096be56acb0af9b1029cf0ba5319f177
https://pubmed.ncbi.nlm.nih.gov/17183161