Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Igor B. Levshin"'
Autor:
Igor B. Levshin, Alexander Yu. Simonov, Alexey A. Panov, Natalia E. Grammatikova, Alexander I. Alexandrov, Eslam S. M. O. Ghazy, Vasiliy A. Ivlev, Michael O. Agaphonov, Alexey B. Mantsyzov, Vladimir I. Polshakov
Publikováno v:
Pharmaceuticals, Vol 17, Iss 6, p 723 (2024)
A series of hybrid compounds with triazole and thiazolidine nuclei connected by a linker has been synthesized and extensively studied. Various synthetic methods for the target compounds have been tested. A microbiological assessment of the obtained c
Externí odkaz:
https://doaj.org/article/13483073eed24242ad00227215e7d07b
Autor:
Igor B. Levshin, Alexander Y. Simonov, Sergey N. Lavrenov, Alexey A. Panov, Natalia E. Grammatikova, Alexander A. Alexandrov, Eslam S. M. O. Ghazy, Nikita A. Savin, Peter V. Gorelkin, Alexander S. Erofeev, Vladimir I. Polshakov
Publikováno v:
Pharmaceuticals, Vol 15, Iss 5, p 563 (2022)
Novel derivatives of Mycosidine (3,5-substituted thiazolidine-2,4-diones) are synthesized by Knoevenagel condensation and reactions of thiazolidines with chloroformates or halo-acetic acid esters. Furthermore, 5-Arylidene-2,4-thiazolidinediones and t
Externí odkaz:
https://doaj.org/article/2f7f303cc2264d6282e8aece6f627613
Publikováno v:
Pharmaceutics, Vol 14, Iss 4, p 864 (2022)
Novel potential antifungal of 1,2,4-triazole class have been synthesized as pure enantiomer (R-98) and racemic (RS-186). The effect of 2-hydroxypropyl-β-cyclodextrin (CD) on the solubility and permeability of RS-186 and R-98 in terms of chiral recog
Externí odkaz:
https://doaj.org/article/6d95888131b14876a250b36ddac1d425
Autor:
Nina A. Rastorgueva, Andrei V. Churakov, Alexandr S. Vedenkin, Alexey V. Kiselev, Sergey V. Stovbun, Vladimir I. Polshakov, Igor B. Levshin, Oleg Yu. Saveliev
Publikováno v:
Chemistry of Heterocyclic Compounds. 55:178-183
The direction of the benzoylation reaction of thiazolidine-2,4-dione under the conditions of basic and general acid catalysis was studied. It was shown that the direction of benzoylation of thiazolidine-2,4-dione at the cyclic nitrogen atom or oxygen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::802dfd404a526a00e8f5f99ef86d0b3a
https://doi.org/10.1007/s10593-019-02436-2
https://doi.org/10.1007/s10593-019-02436-2
Autor:
German L. Perlovich, Svetlana V. Blokhina, Igor B. Levshin, Angelica V. Sharapova, Marina V. Ol’khovich
Publikováno v:
Journal of Molecular Liquids. 337:116395
New thiazolo[4,5-d]pyrimidine derivatives were synthesized as potential antifungal agents. The amorphous nature of the obtained compounds was verified by DSC and PXRD. The kinetic and equilibrium solubilities of the derivatives were studied by the sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a18934c420154e8c8e78a2c650441e9
https://doi.org/10.1016/j.molliq.2021.116395
https://doi.org/10.1016/j.molliq.2021.116395
Publikováno v:
Journal of Molecular Liquids. 336:116535
Novel potential antifungal compound of 1,2,4-triazole class − 3,3‘-(piperazine-1,4-diyl)bis(2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)propan-2-ol) (S-119) - has been synthesized and characterized. Solubility in buffer solutions (pH 2.0 and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab2f49a37d60fd16eba910a385a672f4
https://doi.org/10.1016/j.molliq.2021.116535
https://doi.org/10.1016/j.molliq.2021.116535
Autor:
Irina A. Doroshenko, Marina V. Ol’khovich, German L. Perlovich, Igor B. Levshin, Angelica V. Sharapova, Svetlana V. Blokhina
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 40:127944
Synthesis and antifungal activity of hybrids of thiazolo[4,5-d]pyrimidines with (1H-1,2,4)triazoles are presented. The solubility and lipophilicity of compounds was assessed and it was discovered that compounds with piperazine linker exhibited signif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ad34cb0f463cff7f3b3959256fd4c6c
https://doi.org/10.1016/j.bmcl.2021.127944
https://doi.org/10.1016/j.bmcl.2021.127944
Autor:
German L. Perlovich, Igor B. Levshin, Svetlana V. Blokhina, Marina V. Ol’khovich, Angelica V. Sharapova
Publikováno v:
Journal of Molecular Liquids. 326:115273
Novel (5Z)-3-(3-(4-acetylpiperazin-1-yl)-2-hydroxypropyl)-5-(4-chlorobenzylidene)thiazolidine-2,4-dione was synthesized as a potent antimicrobial agent. Its melting enthalpy and melting point temperature were measured to be 44.4 kJ∙mol−1 and 433.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bec4e102e7c6b2ec270a13994f76280c
https://doi.org/10.1016/j.molliq.2020.115273
https://doi.org/10.1016/j.molliq.2020.115273
Autor:
Svetlana V. Blokhina, German L. Perlovich, Igor B. Levshin, Angelica V. Sharapova, Marina V. Ol’khovich
Publikováno v:
Journal of Molecular Liquids. 324:114662
Four novel potential antifungal 1,2,4-triazole hybrids of thiazolopyrimidines with different - methyl-, methoxy-, chloro-, and fluoro- substituents in the molecule phenyl ring were synthesized and characterized by 1H NMR spectra. The PXRD and DSC tec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5c67c88ecc365947e91e8ad1989c429
https://doi.org/10.1016/j.molliq.2020.114662
https://doi.org/10.1016/j.molliq.2020.114662
Publikováno v:
Journal of Molecular Liquids. 310:113148
A novel potential antifungal compound of 1,2,4-triazole class - ((5Z)-5-[(4-chlorophenyl)methylidene]-3-(2-{4-[2-(2,5-difluorophenyl)-2-hydroxy-3-(1,2,4-triazol-1-yl)propyl]piperazin-1-yl}-2-oxoethyl)-1,3-thiazolidine-2,4-dione) (L-173) - has been sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::876d6d962cdc159322bd7e2f75b5fa51
https://doi.org/10.1016/j.molliq.2020.113148
https://doi.org/10.1016/j.molliq.2020.113148