Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Igor B. Bronstein"'
Publikováno v:
Biopolymers
Biopolymers, Wiley, 2012, 97 (8), pp.577-588. ⟨10.1002/bip.22055⟩
Biopolymers, Wiley, 2012, 97 (8), pp.577-588. ⟨10.1002/bip.22055⟩
Proteins are folded during their synthesis; this process may be spontaneous or assisted. Both phenomena are carefully regulated by the “housekeeping” mechanism and molecular chaperones to avoid the appearance of misfolded proteins. Unfolding proc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::097c71fff84251b7c09c78bd49445228
Publikováno v:
Journal of Molecular Biology. 411:1072-1082
The S100 family, with about 20 members in humans, is composed of EF-hand calcium-regulated proteins and is linked to a range of serious human diseases, including cancer and autoimmune and neurological disorders. The oldest S100 family members are fou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61b59b9517b209dab26792a045c8d0eb
https://doi.org/10.1016/j.jmb.2011.06.048
https://doi.org/10.1016/j.jmb.2011.06.048
Autor:
Igor B. Bronstein, Christopher R. Lowe, Judith Webster, David Oxley, Duncan S. Young, Denise V. Dear, Filip Meersman, Andrew C. Gill
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1794:1123-1133
Deimination is the post-translational conversion of arginine residues to citrulline. It has been implicated as a causative factor in autoimmune diseases such as multiple sclerosis and rheumatoid arthritis and more recently, as a marker of neurodegene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::260af3481880f1866a51567c53c5ca8d
https://doi.org/10.1016/j.bbapap.2009.03.013
https://doi.org/10.1016/j.bbapap.2009.03.013
Publikováno v:
Journal of Neurochemistry. 102:398-407
Defects in axonal transport and synaptic dysfunctions are associated with early stages of several neurodegenerative diseases including Alzheimer's, Huntington's, Parkinson's, and prion diseases. Here, we tested the effect of full-length mammalian pri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0033ff287da472623043222be98248ce
https://doi.org/10.1111/j.1471-4159.2007.04537.x
https://doi.org/10.1111/j.1471-4159.2007.04537.x
Publikováno v:
Journal of Biological Chemistry. 282:4218-4231
Calgranulin C (S100A12) is a member of the S100 family of proteins that undergoes a conformational change upon calcium binding allowing them to interact with target molecules and initiate biological responses; one such target is the receptor for adva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a5fbe9cfad0c8fa45cd8e4e6ee39ef0
https://doi.org/10.1074/jbc.m608888200
https://doi.org/10.1074/jbc.m608888200
Publikováno v:
Journal of Biological Chemistry. 281:13828-13836
A growing body of evidence indicates that small, soluble oligomeric species generated from a variety of proteins and peptides rather than mature amyloid fibrils are inherently highly cytotoxic. Here, we show for the first time that mature amyloid fib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86bbd938aeadae246698d606f191b983
https://doi.org/10.1074/jbc.m511174200
https://doi.org/10.1074/jbc.m511174200
Publikováno v:
Biochemical Society Transactions. 31:985-989
Electrospray ionization has made possible the transference of non-covalently bound complexes from solution phase to high vacuum. In the process, a complex acquires a net charge and becomes amenable to measurement by MS. FTICR (Fourier-transform ion c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a749cab5e8faf23064fd1d418a302143
https://doi.org/10.1042/bst0310985
https://doi.org/10.1042/bst0310985
Publikováno v:
Microscopy Research and Technique. 60:581-592
S100A12 is a member of the S100 family of EF-hand calcium-binding proteins. Together with two other calgranulins, S100A8 and S100A9, it is mostly expressed in human granulocytes, although there is increasing evidence of expression in keratinocytes an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ddb1023340a22094b42d9bc64b113bb
https://doi.org/10.1002/jemt.10300
https://doi.org/10.1002/jemt.10300
Publikováno v:
Human Pathology. 33:599-607
New anticancer drugs targeting DNA topoisomerase I (topo I) are showing activity against human sarcomas. Laboratory studies have indicated that cells responsive to topo I-targeted drugs have elevated levels of topo I, require active DNA replication,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4255ee3af982acbb64f6916d3f0971b
https://doi.org/10.1053/hupa.2002.124911
https://doi.org/10.1053/hupa.2002.124911
Autor:
Olga Ustinova, Konstantin Mochalov, Igor B. Bronstein, Igor Nabiev, Vladimir Oleinikov, Irina A. Kudelina, Alyona Sukhanova
Publikováno v:
Biopolymers
Biopolymers, Wiley, 2002, 67 (6), pp.369-375. ⟨10.1002/bip.10141⟩
Biopolymers, Wiley, 2002, 67 (6), pp.369-375. ⟨10.1002/bip.10141⟩
We employed Raman and circular dichroism (CD) spectroscopy to probe the molecular structure of 68-kDa recombinant human DNA topoisomerase I (TopoI) in solution, in a complex with a 16-bp DNA fragment containing a camptothecin-enhanced TopoI cleavage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9e4b8a6590d47c5f9e4bb375df15e21
https://doi.org/10.1002/bip.10141
https://doi.org/10.1002/bip.10141