Výsledky vyhledávání - "Igor Alabugin"

Akademický článek

Discovery of Di(het)arylmethane and Dibenzoxanthene Derivatives as Potential Anticancer Agents

Autor: Andrey Smolobochkin, Dinara Niyazova, Almir Gazizov, Marat Syzdykbayev, Alexandra Voloshina, Syumbelya Amerhanova, Anna Lyubina, Margarita Neganova, Yulia Aleksandrova, Olga Babaeva, Julia Voronina, Nurbol Appazov, Oleg Sinyashin, Igor Alabugin, Alexander Burilov, Michail Pudovik

Publikováno v: International Journal of Molecular Sciences, Vol 25, Iss 12, p 6724 (2024)

A family of bifunctional dihetarylmethanes and dibenzoxanthenes is assembled via a reaction of acetals containing a 2-chloroacetamide moiety with phenols and related oxygen-containing heterocycles. These compounds demonstrated selective antitumor act

Externí odkaz: https://doaj.org/article/1211386e6f274ea8af25c194fc085637

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Akademický článek

Anticancer and Antiphytopathogenic Activity of Fluorinated Isatins and Their Water-Soluble Hydrazone Derivatives

Autor: Andrei V. Bogdanov, Margarita Neganova, Alexandra Voloshina, Anna Lyubina, Syumbelya Amerhanova, Igor A. Litvinov, Olga Tsivileva, Nurgali Akylbekov, Rakhmetulla Zhapparbergenov, Zulfiia Valiullina, Alexandr V. Samorodov, Igor Alabugin

Publikováno v: International Journal of Molecular Sciences, Vol 24, Iss 20, p 15119 (2023)

A series of new fluorinated 1-benzylisatins was synthesized in high yields via a simple one-pot procedure in order to explore the possible effect of ortho-fluoro (3a), chloro (3b), or bis-fluoro (3d) substitution on the biological activity of this ph

Externí odkaz: https://doaj.org/article/f1890d8445e543d0a8d83a9907f17f6f

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Akademický článek

Hybrids of Sterically Hindered Phenols and Diaryl Ureas: Synthesis, Switch from Antioxidant Activity to ROS Generation and Induction of Apoptosis

Publikováno v: International Journal of Molecular Sciences, Vol 24, Iss 16, p 12637 (2023)

The utility of sterically hindered phenols (SHPs) in drug design is based on their chameleonic ability to switch from an antioxidant that can protect healthy tissues to highly cytotoxic species that can target tumor cells. This work explores the biol

Externí odkaz: https://doaj.org/article/1071746952fa40ceb533c9ed9f0a574a

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Akademický článek

Photochemical Uncaging of Aldehydes and Ketones via Photocyclization/Fragmentation Cascades of Enyne Alcohols: An Unusual Application for a Cycloaromatization Process

Autor: Adam Campbell, Nikolas R. Dos Santos, Igor Alabugin

Publikováno v: Molecules, Vol 28, Iss 15, p 5704 (2023)

We utilized a cycloaromatization reaction driven by relief of excited state antiaromaticity to photouncage aldehydes and ketones. We developed several synthetic routes towards the synthesis of photocaged carbonyls as allylically substituted 3-(2-(ary

Externí odkaz: https://doaj.org/article/1341870216e2418d8982093d972c21a9

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Akademický článek

Tribute to Josef Michl

Autor: Igor Alabugin, Petr Klán

Publikováno v: Chemistry, Vol 3, Iss 1, Pp 440-443 (2021)

It is our great pleasure to introduce the Festschrift of Chemistry to honor professor Josef Michl (Figure 1) on the occasion of his 80th birthday and to recognize his exceptional contributions to the fields of organic photochemistry, quantum chemistr

Externí odkaz: https://doaj.org/article/bb3ed288ada64c20b33ff9b624a4f8d3

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Akademický článek

Diverse Biological Activity of Benzofuroxan/Sterically Hindered Phenols Hybrids

Autor: Elena Chugunova, Elmira Gibadullina, Kirill Matylitsky, Baurat Bazarbayev, Margarita Neganova, Konstantin Volcho, Artem Rogachev, Nurgali Akylbekov, Hoang Bao Tran Nguyen, Alexandra Voloshina, Anna Lyubina, Syumbelya Amerhanova, Victor Syakaev, Alexander Burilov, Nurbol Appazov, Mukhtar Zhanakov, Leah Kuhn, Oleg Sinyashin, Igor Alabugin

Publikováno v: Pharmaceuticals, Vol 16, Iss 4, p 499 (2023)

Combining two pharmacophores in a molecule can lead to useful synergistic effects. Herein, we show hybrid systems that combine sterically hindered phenols with dinitrobenzofuroxan fragments exhibit a broad range of biological activities. The modular

Externí odkaz: https://doaj.org/article/e65e5cbc8125486ab59ef1ef8dbc71c1

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