Zobrazeno 1 - 10
of 162
pro vyhledávání: '"Igor A. Mikhailopulo"'
Autor:
Barbara Z. Eletskaya, Anton F. Mironov, Ilya V. Fateev, Maria Ya. Berzina, Konstantin V. Antonov, Olga S. Smirnova, Alexandra B. Zatsepina, Alexandra O. Arnautova, Yulia A. Abramchik, Alexander S. Paramonov, Alexey L. Kayushin, Anastasia L. Khandazhinskaya, Elena S. Matyugina, Sergey N. Kochetkov, Anatoly I. Miroshnikov, Igor A. Mikhailopulo, Roman S. Esipov, Irina D. Konstantinova
Publikováno v:
Biomolecules, Vol 14, Iss 7, p 798 (2024)
Enzymatic transglycosylation of the fleximer base 4-(4-aminopyridine-3-yl)-1H-pyrazole using recombinant E. coli purine nucleoside phosphorylase (PNP) resulted in the formation of “non-typical” minor products of the reaction. In addition to “ty
Externí odkaz:
https://doaj.org/article/6dc5ba4973204c2f85cf40e3a5e85b6f
Autor:
Julia N. Artsemyeva, Ekaterina A. Remeeva, Tatiana N. Buravskaya, Irina D. Konstantinova, Roman S. Esipov, Anatoly I. Miroshnikov, Natalia M. Litvinko, Igor A. Mikhailopulo
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 16, Iss 1, Pp 2607-2622 (2020)
In the present work, we suggested anion exchange resins in the phosphate form as a source of phosphate, one of the substrates of the phosphorolysis of uridine, thymidine, and 1-(β-ᴅ-arabinofuranosyl)uracil (Ara-U) catalyzed by recombinant E. coli
Externí odkaz:
https://doaj.org/article/629ea6a1bcea484e97d3d9df7ed67155
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 12, Iss 1, Pp 2588-2601 (2016)
The trans-2-deoxyribosylation of 4-thiouracil (4SUra) and 2-thiouracil (2SUra), as well as 6-azauracil, 6-azathymine and 6-aza-2-thiothymine was studied using dG and E. coli purine nucleoside phosphorylase (PNP) for the in situ generation of 2-deoxy-
Externí odkaz:
https://doaj.org/article/683a0843ae444215842bd2c783181db6
Autor:
Alexey L. Kayushin, Julia A. Tokunova, Ilja V. Fateev, Alexandra O. Arnautova, Maria Ya. Berzina, Alexander S. Paramonov, Olga I. Lutonina, Elena V. Dorofeeva, Konstantin V. Antonov, Roman S. Esipov, Igor A. Mikhailopulo, Anatoly I. Miroshnikov, Irina D. Konstantinova
Publikováno v:
Biomolecules, Vol 11, Iss 4, p 539 (2021)
During the preparative synthesis of 2-fluorocordycepin from 2-fluoroadenosine and 3′-deoxyinosine catalyzed by E. coli purine nucleoside phosphorylase, a slowdown of the reaction and decrease of yield down to 5% were encountered. An unknown nucleos
Externí odkaz:
https://doaj.org/article/87d96404467d4b1785d17ba5e85c74d5
Autor:
Ilja V. Fateev, Konstantin V. Antonov, Irina D. Konstantinova, Tatyana I. Muravyova, Frank Seela, Roman S. Esipov, Anatoly I. Miroshnikov, Igor A. Mikhailopulo
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 10, Iss 1, Pp 1657-1669 (2014)
Two approaches to the synthesis of 2-chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)adenine (1, clofarabine) were studied. The first approach consists in the chemical synthesis of 2-deoxy-2-fluoro-α-D-arabinofuranose-1-phosphate (12a, 2FAra-1P) vi
Externí odkaz:
https://doaj.org/article/dfe3850d578749a6960d92fee88a7bfe
Autor:
Ekaterina A Remeeva, Irina D. Konstantinova, Igor A. Mikhailopulo, Anatoly I. Miroshnikov, Natalia M Litvinko, Tatiana N Buravskaya, Julia N Artsemyeva, Roman S. Esipov
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 16, Iss 1, Pp 2607-2622 (2020)
Beilstein Journal of Organic Chemistry
Beilstein Journal of Organic Chemistry
In the present work, we suggested anion exchange resins in the phosphate form as a source of phosphate, one of the substrates of the phosphorolysis of uridine, thymidine, and 1-(β-ᴅ-arabinofuranosyl)uracil (Ara-U) catalyzed by recombinant E. coli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d02a426172e5cb5cbca6257d84f86ce5
https://doaj.org/article/629ea6a1bcea484e97d3d9df7ed67155
https://doaj.org/article/629ea6a1bcea484e97d3d9df7ed67155
Autor:
Peter Neubauer, Zhen Huang, Weizhu Yan, Chong Zhang, Xinrui Zhou, Igor A. Mikhailopulo, Zhaoyi Yang
Publikováno v:
Catalysis Communications. 121:32-37
Selenium-containing nucleosides are the building blocks of the Se-nucleic acids useful for structure-and-function study, drug discovery and for targeting nucleic acids and their protein complexes. However, chemical synthesis of these Se-containing nu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f48c5897e24e81d0c8e2b4c58420f32
https://doi.org/10.1016/j.catcom.2018.12.004
https://doi.org/10.1016/j.catcom.2018.12.004
Autor:
Hendrik F. T. Klare, Igor A. Mikhailopulo, Anke Wagner, Sarah Kamel, Max Weiß, Peter Neubauer
Publikováno v:
Molecular Catalysis. 458:52-59
α- d -pentofuranose-1-phosphates (Pentose-1Ps) are key intermediates in nucleoside metabolism and important precursors for the enzymatic synthesis of modified nucleosides. To date, Pentose-1Ps are mainly produced by chemical approaches which have nu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc4a034ef1b9c8be2508cc4d4d0eabf6
https://doi.org/10.1016/j.mcat.2018.07.028
https://doi.org/10.1016/j.mcat.2018.07.028
Autor:
Elena V Dorofeeva, Alexey L Kayushin, Irina D. Konstantinova, Olga I. Lutonina, Yulia A. Tokunova, Ilja V. Fateev, Vladimir N. Leonov, Roman S. Esipov, Anatoly I. Miroshnikov, Alexandra O. Denisova, Inessa S. Muzyka, Alexandra A. Breslav, Vladimir A. Stepchenko, Igor A. Mikhailopulo
Publikováno v:
Synthesis. 49:4853-4860
Two approaches to the chemoenzymatic synthesis of 2-fluorocordycepin and 2-chlorocordycepin were studied: (i) the use of 3′-deoxyadenosine (cordycepin) and 3′-deoxyinosine (3′dIno) as donors of 3-deoxy-d-ribofuranose in the transglycosylation o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9fd44b57c0979eb340ba0b3e2ea5d431
https://doi.org/10.1055/s-0036-1590804
https://doi.org/10.1055/s-0036-1590804
Publikováno v:
Beilstein Journal of Organic Chemistry
Beilstein Journal of Organic Chemistry, Vol 12, Iss 1, Pp 2588-2601 (2016)
Beilstein Journal of Organic Chemistry, Vol 12, Iss 1, Pp 2588-2601 (2016)
The trans-2-deoxyribosylation of 4-thiouracil (4SUra) and 2-thiouracil (2SUra), as well as 6-azauracil, 6-azathymine and 6-aza-2-thiothymine was studied using dG and E. coli purine nucleoside phosphorylase (PNP) for the in situ generation of 2-deoxy-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc45c964a012f042867613eff435ee5a
http://europepmc.org/articles/PMC5238616
http://europepmc.org/articles/PMC5238616