Reconstructing the landscape of gut microbial species across 29,000 diverse individuals

Autor: Igor Segota, Jeramie D Watrous, Edward D Kantz, Shriram Nallamshetty, Saumya Tiwari, Susan Cheng, Mohit Jain, Tao Long

Publikováno v: Nucleic Acids Research. 51:4178-4190

The human gut microbiome has been linked to health and disease. Investigation of the human microbiome has largely employed 16S amplicon sequencing, with limited ability to distinguish microbes at the species level. Herein, we describe the development

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3c91b9d2b94fb921d868fce2f88dfdf2
https://doi.org/10.1093/nar/gkad249

Confirmation and variability of the Allee effect in Dictyostelium discoideum cell populations, possible role of chemical signaling within cell clusters

Autor: Igor Segota, Matthew M Edwards, Arthur Campello, Brendan H Rappazzo, Xiaoning Wang, Ariana Strandburg-Peshkin, Xiao-Qiao Zhou, Archana Rachakonda, Kayvon Daie, Alexander Lussenhop, Sungsu Lee, Kevin Tharratt, Amrish Deshmukh, Elisabeth M Sebesta, Myron Zhang, Sharon Lau, Sarah Bennedsen, Jared Ginsberg, Timothy Campbell, Chenzheng Wang, Carl Franck

In studies of the unicellular eukaryote Dictyostelium discoideum, many have anecdotally observed that cell dilution below a certain ‘threshold density’ causes cells to undergo a period of slow growth (lag). However, little is documented about the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a1f36d92f7f0810e2edca03589b6882

Prebiotic-Induced Anti-tumor Immunity Attenuates Tumor Growth

Autor: Tao Long, Scott N. Peterson, Linda M. Bradley, Raphy Zarecki, Robert Schmaltz, Rafael R. Segura Munoz, Ze'ev Ronai, Yu Fujita, Roberto Tinoco, Yongmei Feng, Lisa Elmén, Igor Segota, Yibo Xian, Amanda E. Ramer-Tait, Yan Li

Publikováno v: Cell reports, vol 30, iss 6
Cell reports
Cell Reports, Vol 30, Iss 6, Pp 1753-1766.e6 (2020)

SUMMARY Growing evidence supports the importance of gut microbiota in the control of tumor growth and response to therapy. Here, we select prebiotics that can enrich bacterial taxa that promote anti-tumor immunity. Addition of the prebiotics inulin o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7c584b4d2ddbf39d28737a1f9629d56
https://escholarship.org/uc/item/9nw1r3pv

Gut microbiota dependent anti-tumor immunity restricts melanoma growth in Rnf5−/− mice

Autor: Lisa Elmén, Dennie T. Frederick, Yibo Xian, Bas J. G. Baaten, Yan Li, Amir Orian, Hyungsoo Kim, Robert Schmaltz, Kevin M. Brown, Glenn Merlino, Roberto Tinoco, Eytan Ruppin, Ali Khateb, Ilanit Boyango, Avinash Das Sahu, Eva Guijarro Perez, Yongmei Feng, Randal J. Kaufman, Chi-Ping Day, Ze'ev Ronai, Tao Long, Lihi Tzur, Gil Bar-Sela, Emily Avitan-Hersh, Marcus Bosenberg, Shiri K. Ashkenazi, Mitchell P. Levesque, Shoshana Roizman, Linda M. Bradley, Raphy Zarecki, Yu Fujita, Scott N. Peterson, Colin R. Goding, Kerrie L. Marie, Reinhard Dummer, Rafael S. Segura Muñoz, Shibu Yooseph, Keith T. Flaherty, Tongwu Zhang, Amanda E. Ramer-Tait, Igor Segota, Miguel A. Tam

Publikováno v: Nature communications, vol 10, iss 1
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Li, Y, Tinoco, R, Elmén, L, Segota, I, Xian, Y, Fujita, Y, Sahu, A, Zarecki, R, Marie, K L, Feng, Y, Khateb, A, Frederick, D T, Ashkenazi, S K, Kim, H, Pérez-Guijarro, E, Day, C-P, Segura Muñoz, R S, Schmaltz, R, Yooseph, S, Tam, M A, Zhang, T, Avitan-Hersh, E, Tzur, L, Roizman, S, Boyango, I, Bar-Sela, G, Orian, A, Kaufman, R J, Bosenberg, M, Goding, C R, Baaten, B, Levesque, M P, Dummer, R, Brown, K M, Merlino, G, Ruppin, E, Flaherty, K T, Ramer-Tait, A, Long, T, Peterson, S N, Bradley, L M & Ronai, Z A 2019, ' Gut microbiota dependent anti-tumor immunity restricts melanoma growth in Rnf5 −/− mice ', Nature Communications, vol. 10, 1492, pp. 1-16 . https://doi.org/10.1038/s41467-019-09525-y
Nature Communications

Accumulating evidence points to an important role for the gut microbiome in anti-tumor immunity. Here, we show that altered intestinal microbiota contributes to anti-tumor immunity, limiting tumor expansion. Mice lacking the ubiquitin ligase RNF5 exh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::034278988dcad7bc3424498560983469
https://doi.org/10.1038/s41467-019-09525-y

Effect of flow and peristaltic mixing on bacterial growth in a gut-like channel

Autor: John T. Sauls, Alex Groisman, Igor Segota, Markus Arnoldini, Zhongge Zhang, Chih-yu Yang, Edgar Gutierrez, Jonas Cremer, Terence Hwa

Publikováno v: Proceedings of the National Academy of Science of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, vol 113, iss 41

The ecology of microbes in the gut has been shown to play important roles in the health of the host. To better understand microbial growth and population dynamics in the proximal colon, the primary region of bacterial growth in the gut, we built and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1c2b648dbaa827cd84fa442df59000e