Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Igor, Putrenko"'
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Lidocaine is known to inhibit the hyperpolarization-activated mixed cation current (Ih) in cardiac myocytes and neurons, as well in cells transfected with cloned Hyperpolarization-activated Cyclic Nucleotide-gated (HCN) channels. However, th
Externí odkaz:
https://doaj.org/article/0be53e8d7de54a1891114f696cbf88a8
Publikováno v:
PLoS ONE, Vol 15, Iss 7, p e0235758 (2020)
Accurate risk assessment of an individuals' propensity to develop cardiovascular diseases (CVDs) is crucial for the prevention of these conditions. Numerous published risk prediction models used for CVD risk assessment are based on conventional risk
Externí odkaz:
https://doaj.org/article/44498f74ed0148fdbc6830890a613946
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 7, p e0235758 (2020)
PLoS ONE, Vol 15, Iss 7, p e0235758 (2020)
Accurate risk assessment of an individuals' propensity to develop cardiovascular diseases (CVDs) is crucial for the prevention of these conditions. Numerous published risk prediction models used for CVD risk assessment are based on conventional risk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e23e4ff23f49a9d0087aefa94b8b3d0
http://europepmc.org/articles/PMC7390268
http://europepmc.org/articles/PMC7390268
BackgroundStratification of individuals for their risk to develop cardiovascular diseases can be used for effective prevention and intervention. A significant amount of information for risk assessment can be obtained through repurposing electronic he
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::173069405639cadd162576dc600a9ce0
https://doi.org/10.1101/648956
https://doi.org/10.1101/648956
Cardiometabolic diseases (CMD) impose greater impact on every aspect of health care than any other disease group. Accurate and in-time risk assessment of individuals for their propensity to develop CMD events is one of the most critical paths in prev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41ca030c9b37db87e1889fbad6755886
https://doi.org/10.1101/562900
https://doi.org/10.1101/562900
Publikováno v:
Anesthesia & Analgesia. 122:1360-1369
BACKGROUND: High systemic lidocaine concentrations exert well-known toxic effects on the central nervous system (CNS), including seizures, coma, and death. The underlying mechanisms are still largely obscure, and the actions of lidocaine on supraspin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fbcf7479e81ae6399d3c84bcb63eed27
https://doi.org/10.1213/ane.0000000000001158
https://doi.org/10.1213/ane.0000000000001158
Publikováno v:
Structure (London, England : 1993). 24(10)
Cyclic AMP is thought to facilitate the opening of the HCN2 channel by binding to a C-terminal domain and promoting or inhibiting interactions between subunits. Here, we correlated the ability of cyclic nucleotides to promote interactions of isolated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bb15aeb983914efc116db032d378282
https://pubmed.ncbi.nlm.nih.gov/27705814
https://pubmed.ncbi.nlm.nih.gov/27705814
Autor:
Ernest Puil, Craig R. Ries, Bernard A. MacLeod, Richard A. Wall, Ryan A. Whitehead, Igor Putrenko, Stephan K. W. Schwarz, James E. Cooke, Nada A Sallam
Publikováno v:
Neuroscience. 213:154-160
Peripherally restricted analgesics are desirable to avoid central nervous system (CNS) side effects of opioids. Nonsteroidal anti-inflammatory drugs produce peripheral analgesia but have significant toxicity. GABA(B) receptors represent peripheral ta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3705ebc4432959bfd1d1f114e46c0a2
https://doi.org/10.1016/j.neuroscience.2012.04.026
https://doi.org/10.1016/j.neuroscience.2012.04.026
Publikováno v:
Anesthesia and analgesia. 122(5)
High systemic lidocaine concentrations exert well-known toxic effects on the central nervous system (CNS), including seizures, coma, and death. The underlying mechanisms are still largely obscure, and the actions of lidocaine on supraspinal neurons h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3f59fc4b6b02f12aa44aae2cbff073ba
https://pubmed.ncbi.nlm.nih.gov/26771269
https://pubmed.ncbi.nlm.nih.gov/26771269
Publikováno v:
Journal of Biological Chemistry. 280:6392-6398
The genome of the nematode Caenorhabditis elegans encodes a surprisingly large and diverse superfamily of genes encoding Cys loop ligand-gated ion channels. Here we report the first cloning, expression, and pharmacological characterization of members
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2a0a1e862b204e67a9875f1b7339525
https://doi.org/10.1074/jbc.m412644200
https://doi.org/10.1074/jbc.m412644200