Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Igor, Kurinov"'
Autor:
Monica Bubenik, Pavel Mader, Philippe Mochirian, Fréderic Vallée, Jillian Clark, Jean-François Truchon, Alexander L. Perryman, Victor Pau, Igor Kurinov, Karl E. Zahn, Marie-Eve Leclaire, Robert Papp, Marie-Claude Mathieu, Martine Hamel, Nicole M. Duffy, Claude Godbout, Matias Casas-Selves, Jean-Pierre Falgueyret, Prasamit S. Baruah, Olivier Nicolas, Rino Stocco, Hugo Poirier, Giovanni Martino, Alexanne Bonneau Fortin, Anne Roulston, Amandine Chefson, Stéphane Dorich, Miguel St-Onge, Purvish Patel, Charles Pellerin, Stéphane Ciblat, Thomas Pinter, Francis Barabé, Majida El Bakkouri, Paranjay Parikh, Christian Gervais, Agnel Sfeir, Yael Mamane, Stephen J. Morris, W. Cameron Black, Frank Sicheri, Michel Gallant
Publikováno v:
Journal of Medicinal Chemistry. 65:13198-13215
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::947c93bf7b6803db8ed4beb935e92af5
https://doi.org/10.1021/acs.jmedchem.2c00998
https://doi.org/10.1021/acs.jmedchem.2c00998
Autor:
Chetan K. Chana, Pierre Maisonneuve, Ganna Posternak, Nicolas G.A. Grinberg, Juline Poirson, Samara M. Ona, Derek F. Ceccarelli, Pavel Mader, Daniel J. St-Cyr, Victor Pau, Igor Kurinov, Xiaojing Tang, Dongjing Deng, Weiren Cui, Wenji Su, Letian Kuai, Richard Soll, Mike Tyers, Hannes L. Röst, Robert A. Batey, Mikko Taipale, Anne-Claude Gingras, Frank Sicheri
Publikováno v:
Journal of Medicinal Chemistry. 65:12725-12746
Targeted protein degradation (TPD) strategies exploit bivalent small molecules to bridge substrate proteins to an E3 ubiquitin ligase to induce substrate degradation. Few E3s have been explored as degradation effectors due to a dearth of E3-binding s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e9bd44e2ad315c9a8487c6d1e86a88a
https://doi.org/10.1021/acs.jmedchem.2c00509
https://doi.org/10.1021/acs.jmedchem.2c00509
Autor:
Zigang Dong, Ziming Dong, Ann M. Bode, Yuqiao Sheng, Do Young Lim, Wei Li, Hanyong Chen, Haitao Li, Ke Yao, Feng Zhu, Igor Kurinov, Margarita Malakhova, Yang Fu, Ge Yang
X-ray data collection and refinement statistics.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c7d8d67f133359d512cd828f9407db1
https://doi.org/10.1158/1940-6207.22524335.v1
https://doi.org/10.1158/1940-6207.22524335.v1
Autor:
Zigang Dong, Ziming Dong, Ann M. Bode, Yuqiao Sheng, Do Young Lim, Wei Li, Hanyong Chen, Haitao Li, Ke Yao, Feng Zhu, Igor Kurinov, Margarita Malakhova, Yang Fu, Ge Yang
Knockdown of ERK2 in HaCaT cells decreases sensitivity to caffeic acid. A, efficiency of ERK2 shRNA in HaCaT cells. B, neoplastic transformation of HaCaT cells transfected with mock shRNA, ERK2 shRNA#1 or ERK2 shRNA#2. Cell transformation dramaticall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b435761b66f19f2ad218927d3abd22aa
https://doi.org/10.1158/1940-6207.22524341
https://doi.org/10.1158/1940-6207.22524341
Autor:
Zigang Dong, Ziming Dong, Ann M. Bode, Yuqiao Sheng, Do Young Lim, Wei Li, Hanyong Chen, Haitao Li, Ke Yao, Feng Zhu, Igor Kurinov, Margarita Malakhova, Yang Fu, Ge Yang
Supplemental Figure Legend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c6e70cb37592c50127fe9366201fef5
https://doi.org/10.1158/1940-6207.22524338
https://doi.org/10.1158/1940-6207.22524338
Autor:
Zigang Dong, Ziming Dong, Ann M. Bode, Yuqiao Sheng, Do Young Lim, Wei Li, Hanyong Chen, Haitao Li, Ke Yao, Feng Zhu, Igor Kurinov, Margarita Malakhova, Yang Fu, Ge Yang
Caffeic acid attenuates MAP kinase signal transduction in HaCaT cells After starvation in serum-free medium for 24 h, cells were treated with caffeic acid at the indicated concentration for 1 h and then were exposed to solar UV (60 kJ UVA/m2, 3.6 UVB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3e14d4ee6d665014c3d2a0b0c09d0b2
https://doi.org/10.1158/1940-6207.22524344.v1
https://doi.org/10.1158/1940-6207.22524344.v1
Autor:
Zigang Dong, Ziming Dong, Ann M. Bode, Yuqiao Sheng, Do Young Lim, Wei Li, Hanyong Chen, Haitao Li, Ke Yao, Feng Zhu, Igor Kurinov, Margarita Malakhova, Yang Fu, Ge Yang
Caffeic acid attenuates EGF-induced cell transformation. A, caffeic acid is not toxic to HaCaT cells. Cells were treated with caffeic acid (0-80 µmol/L) or its vehicle, DMSO (as a negative control) in 10% FBS/DMEM for 24 or 48 h. Cell viability was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ffc590afd573cf2595d53785d631fc9
https://doi.org/10.1158/1940-6207.22524347.v1
https://doi.org/10.1158/1940-6207.22524347.v1
Autor:
Gregory D. Martyn, Gianluca Veggiani, Ulrike Kusebauch, Seamus R. Morrone, Bradley P. Yates, Alex U. Singer, Jiefei Tong, Noah Manczyk, Gerald Gish, Zhi Sun, Igor Kurinov, Frank Sicheri, Michael F. Moran, Robert L. Moritz, Sachdev S. Sidhu
Publikováno v:
ACS Chem Biol
A comprehensive analysis of the phosphoproteome is essential for understanding molecular mechanisms of human diseases. However, current tools used to enrich phosphotyrosine (pTyr) are limited in their applicability and scope. Here, we engineered new
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da7b589c2dcc874e1febc7789a5a028c
https://doi.org/10.1021/acschembio.2c00051
https://doi.org/10.1021/acschembio.2c00051
Autor:
Monica, Bubenik, Pavel, Mader, Philippe, Mochirian, Fréderic, Vallée, Jillian, Clark, Jean-François, Truchon, Alexander L, Perryman, Victor, Pau, Igor, Kurinov, Karl E, Zahn, Marie-Eve, Leclaire, Robert, Papp, Marie-Claude, Mathieu, Martine, Hamel, Nicole M, Duffy, Claude, Godbout, Matias, Casas-Selves, Jean-Pierre, Falgueyret, Prasamit S, Baruah, Olivier, Nicolas, Rino, Stocco, Hugo, Poirier, Giovanni, Martino, Alexanne Bonneau, Fortin, Anne, Roulston, Amandine, Chefson, Stéphane, Dorich, Miguel, St-Onge, Purvish, Patel, Charles, Pellerin, Stéphane, Ciblat, Thomas, Pinter, Francis, Barabé, Majida, El Bakkouri, Paranjay, Parikh, Christian, Gervais, Agnel, Sfeir, Yael, Mamane, Stephen J, Morris, W Cameron, Black, Frank, Sicheri, Michel, Gallant
Publikováno v:
Journal of medicinal chemistry. 65(19)
DNA polymerase theta (Polθ) is an attractive synthetic lethal target for drug discovery, predicted to be efficacious against breast and ovarian cancers harboring BRCA-mutant alleles. Here, we describe our hit-to-lead efforts in search of a selective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::531f44b082fb5f00fe6c2f82d97a48bc
https://pubmed.ncbi.nlm.nih.gov/36126059
https://pubmed.ncbi.nlm.nih.gov/36126059
Autor:
Yong Geng, Lidia Mosyak, Igor Kurinov, Hao Zuo, Emmanuel Sturchler, Tat Cheung Cheng, Prakash Subramanyam, Alice P Brown, Sarah C Brennan, Hee-chang Mun, Martin Bush, Yan Chen, Trang X Nguyen, Baohua Cao, Donald D Chang, Matthias Quick, Arthur D Conigrave, Henry M Colecraft, Patricia McDonald, Qing R Fan
Publikováno v:
eLife, Vol 5 (2016)
Human calcium-sensing receptor (CaSR) is a G-protein-coupled receptor (GPCR) that maintains extracellular Ca2+ homeostasis through the regulation of parathyroid hormone secretion. It functions as a disulfide-tethered homodimer composed of three main
Externí odkaz:
https://doaj.org/article/e63fb37743704af49f79c4f8b8cc2622