Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Igor, Cervenka"'
Autor:
Serge Ducommun, Paulo R. Jannig, Igor Cervenka, Marta Murgia, Melanie J. Mittenbühler, Ekaterina Chernogubova, José M. Dias, Baptiste Jude, Jorge C. Correia, Jonathan G. Van Vranken, Gabriel Ocana-Santero, Margareta Porsmyr-Palmertz, Sarah McCann Haworth, Vicente Martínez-Redondo, Zhengye Liu, Mattias Carlström, Matthias Mann, Johanna T. Lanner, Ana I. Teixeira, Lars Maegdefessel, Bruce M. Spiegelman, Jorge L. Ruas
Publikováno v:
Molecular Metabolism, Vol 82, Iss , Pp 101912- (2024)
Objective: Skeletal muscle plasticity and remodeling are critical for adapting tissue function to use, disuse, and regeneration. The aim of this study was to identify genes and molecular pathways that regulate the transition from atrophy to compensat
Externí odkaz:
https://doaj.org/article/2abd30b26178418fbe5ccf30fb438f44
Autor:
Marcus Moberg, William Apró, Igor Cervenka, Björn Ekblom, Gerrit van Hall, Hans-Christer Holmberg, Jorge L. Ruas, Eva Blomstrand
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract This study examined acute molecular responses to concurrent exercise involving different muscles. Eight men participated in a randomized crossover-trial with two sessions, one where they performed interval cycling followed by upper body resi
Externí odkaz:
https://doaj.org/article/06362132992943c3be5970aa6e96d42f
Autor:
Duarte M. S. Ferreira, Arthur J. Cheng, Leandro Z. Agudelo, Igor Cervenka, Thomas Chaillou, Jorge C. Correia, Margareta Porsmyr-Palmertz, Manizheh Izadi, Alicia Hansson, Vicente Martínez-Redondo, Paula Valente-Silva, Amanda T. Pettersson-Klein, Jennifer L. Estall, Matthew M. Robinson, K. Sreekumaran Nair, Johanna T. Lanner, Jorge L. Ruas
Publikováno v:
Skeletal Muscle, Vol 9, Iss 1, Pp 1-19 (2019)
Abstract Background Skeletal muscle mass and strength are crucial determinants of health. Muscle mass loss is associated with weakness, fatigue, and insulin resistance. In fact, it is predicted that controlling muscle atrophy can reduce morbidity and
Externí odkaz:
https://doaj.org/article/2f827301045e4b2e8bc503169f19361b
Autor:
Leandro Z. Agudelo, Duarte M. S. Ferreira, Shamim Dadvar, Igor Cervenka, Lars Ketscher, Manizheh Izadi, Liu Zhengye, Regula Furrer, Christoph Handschin, Tomas Venckunas, Marius Brazaitis, Sigitas Kamandulis, Johanna T. Lanner, Jorge L. Ruas
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
PGC-1α is activated by exercise and promotes resistance to fatigue in muscles. Here, the authors show that PGC-1α activates the malate-aspartate shuttle, and allows muscle to utilise kynurenine, leading to more efficient glucose oxidation and mitoc
Externí odkaz:
https://doaj.org/article/4a97fef9ea204ae2827332216ca511a8
Autor:
Yildiz Kelahmetoglu, Paulo R. Jannig, Igor Cervenka, Lauren G. Koch, Steven L. Britton, Jiajia Zhou, Huating Wang, Matthew M. Robinson, K Sreekumaran Nair, Jorge L. Ruas
Publikováno v:
Frontiers in Endocrinology, Vol 11 (2020)
Increasing exercise capacity promotes healthy aging and is strongly associated with lower mortality rates. In this study, we analyzed skeletal muscle transcriptomics coupled to exercise performance in humans and rats to dissect the inherent and respo
Externí odkaz:
https://doaj.org/article/8bff6e8df1fa4140a9745a039a4930a2
Autor:
Paula Valente-Silva, Igor Cervenka, Duarte M. S. Ferreira, Jorge C. Correia, Sebastian Edman, Oscar Horwath, Benjamin Heng, Sharron Chow, Kelly R. Jacobs, Gilles J. Guillemin, Eva Blomstrand, Jorge L. Ruas
Publikováno v:
Metabolites, Vol 11, Iss 8, p 508 (2021)
The kynurenine pathway of tryptophan (TRP) degradation (KP) generates metabolites with effects on metabolism, immunity, and mental health. Endurance exercise training can change KP metabolites by changing the levels of KP enzymes in skeletal muscle.
Externí odkaz:
https://doaj.org/article/d6be93da9340459299420e64da18807c
Autor:
Hannes, Schihada, Thomas M, Klompstra, Laura J, Humphrys, Igor, Cervenka, Shamim, Dadvar, Peter, Kolb, Jorge L, Ruas, Gunnar, Schulte
Publikováno v:
The Journal of biological chemistry. 298(9)
Within the intestine, the human G protein-coupled receptor (GPCR) GPR35 is involved in oncogenic signaling, bacterial infections, and inflammatory bowel disease. GPR35 is known to be expressed as two distinct isoforms that differ only in the length o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::195b442cc7f8e1c3d4c883eb22bdb3e0
https://pubmed.ncbi.nlm.nih.gov/35933013
https://pubmed.ncbi.nlm.nih.gov/35933013
Autor:
Christoph Handschin, Marius Brazaitis, Tomas Venckunas, Igor Cervenka, Shamim Dadvar, Duarte M. S. Ferreira, Regula Furrer, Liu Zhengye, Lars Ketscher, Jorge L. Ruas, Johanna T. Lanner, Leandro Z. Agudelo, Manizheh Izadi, Sigitas Kamandulis
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Nature Communications
Nature Communications
The coactivator PGC-1α1 is activated by exercise training in skeletal muscle and promotes fatigue-resistance. In exercised muscle, PGC-1α1 enhances the expression of kynurenine aminotransferases (Kats), which convert kynurenine into kynurenic acid.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::983debdc6c07968c54ef411cb494b72f
http://link.springer.com/article/10.1038/s41467-019-10712-0
http://link.springer.com/article/10.1038/s41467-019-10712-0
Autor:
David E. Lee, Walter Bottje, Tyrone A. Washington, Byungwhi C. Kong, Igor Cervenka, Nicholas P. Greene, Lemuel A. Brown, Jacob L. Brown, Thomas A. Blackwell, Richard A. Perry, Megan E. Rosa-Caldwell, Jorge L. Ruas, Bhuwan Khatri, Wesley S. Haynie, Michael P. Wiggs
Publikováno v:
Physiological Genomics. 50:1071-1082
Cancer-cachexia (CC) is a wasting condition directly responsible for 20–40% of cancer-related deaths. The mechanisms controlling development of CC-induced muscle wasting are not fully elucidated. Most investigations focus on the postcachectic state
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcbd861032c9856854f41b9416b523a7
https://doi.org/10.1152/physiolgenomics.00061.2018
https://doi.org/10.1152/physiolgenomics.00061.2018
Autor:
Christoph Schweingruber, Yildiz Kelahmetoglu, Johanna T. Lanner, Naveen Khan, Sandra Kleiner, Paulo R. Jannig, Jorge C. Correia, Jorge L. Ruas, Jik Nijssen, Dasa Svaikovskaya, Mariana M.S. Oliveira, Vicente Martínez-Redondo, Liu Zhengye, Eva Hedlund, Michael Stec, Igor Cervenka
SUMMARYEndurance exercise promotes skeletal muscle vascularization, oxidative metabolism, fiber-type switching, and neuromuscular junction integrity. Importantly, the metabolic and contractile properties of the muscle fiber must be coupled to the ide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ecb7a1eb6869f64bdc8ba38124862ed0
https://doi.org/10.1101/2021.03.31.437883
https://doi.org/10.1101/2021.03.31.437883
