Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Ignazia Tusa"'
Autor:
Giulia Lori, Mirella Pastore, Nadia Navari, Benedetta Piombanti, Richell Booijink, Elisabetta Rovida, Ignazia Tusa, Monika Lewinska, Jesper B. Andersen, Tiziano Lottini, Annarosa Arcangeli, Maria Letizia Taddei, Erica Pranzini, Caterina Mancini, Cecilia Anceschi, Stefania Madiai, Elena Sacco, Stefano Rota, Adriana Trapani, Gennaro Agrimi, Matteo Ramazzotti, Paola Ostano, Caterina Peraldo Neia, Matteo Parri, Fabrizia Carli, Silvia Sabatini, Amalia Gastaldelli, Fabio Marra, Chiara Raggi
Publikováno v:
JHEP Reports, Vol 6, Iss 10, Pp 101182- (2024)
Background & Aims: Among the reprogrammed metabolic pathways described in cancer stem cells, aberrant lipid metabolism has recently drawn increasing attention. Our study explored the contribution of fatty acids (FA) in the regulation of stem-like fea
Externí odkaz:
https://doaj.org/article/0e4e35c1e77e4d688cf832f371555c98
Autor:
Beatrice Foglia, Salvatore Sutti, Stefania Cannito, Chiara Rosso, Marina Maggiora, Riccardo Autelli, Erica Novo, Claudia Bocca, Gianmarco Villano, Naresh Naik Ramavath, Ramy Younes, Ignazia Tusa, Elisabetta Rovida, Patrizia Pontisso, Elisabetta Bugianesi, Emanuele Albano, Maurizio Parola
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 2, Pp 459-482 (2022)
Background & Aims: Hypoxia and hypoxia-inducible factors (HIFs) are involved in chronic liver disease progression. We previously showed that hepatocyte HIF-2α activation contributed significantly to nonalcoholic fatty liver disease progression in ex
Externí odkaz:
https://doaj.org/article/9dd50bbb93b94e6ebc56f2862508dc66
Publikováno v:
Cells, Vol 12, Iss 8, p 1154 (2023)
Oxidative stress regulates many physiological and pathological processes. Indeed, a low increase in the basal level of reactive oxygen species (ROS) is essential for various cellular functions, including signal transduction, gene expression, cell sur
Externí odkaz:
https://doaj.org/article/3c694ce8dc384565bbf9bb559b13410a
Autor:
Elisabetta Rovida, Ignazia Tusa
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 10, p 5702 (2022)
Mitogen-activated protein kinase (MAPK) pathways are prominently involved in the onset and progression of cancer [...]
Externí odkaz:
https://doaj.org/article/8ea2ec7322274fd594740f0efb00879e
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Molecularly tailored therapies have opened a new era, chronic myeloid leukemia being the ideal example, in the treatment of cancer. However, available therapeutic options are still unsatisfactory in many types of cancer, and often fail due to the occ
Externí odkaz:
https://doaj.org/article/045b7e6d60894d7495fd6b713072dff7
Autor:
Ignazia Tusa, Giulia Cheloni, Martina Poteti, Antonella Gozzini, Ngoc Ho DeSouza, Yi Shan, Xianming Deng, Nathanael S. Gray, Shaoguang Li, Elisabetta Rovida, Persio Dello Sbarba
Publikováno v:
Stem Cell Reports, Vol 11, Iss 4, Pp 929-943 (2018)
Summary: Tyrosine kinase inhibitors (TKi) are effective against chronic myeloid leukemia (CML), but their inefficacy on leukemia stem cells (LSCs) may lead to relapse. To identify new druggable targets alternative to BCR/ABL, we investigated the role
Externí odkaz:
https://doaj.org/article/191dc7197e484db881356d8b13f286f0
Autor:
Ignazia Tusa, Sinforosa Gagliardi, Alessandro Tubita, Silvia Pandolfi, Alessio Menconi, Matteo Lulli, Persio Dello Sbarba, Barbara Stecca, Elisabetta Rovida
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 20, p 11259 (2021)
Malignant melanoma is the deadliest skin cancer, with a poor prognosis in advanced stages. We recently showed that the extracellular signal-regulated kinase 5 (ERK5), encoded by the MAPK7 gene, plays a pivotal role in melanoma by regulating cell func
Externí odkaz:
https://doaj.org/article/fd20f73031d443fe868f1de7e7343173
Autor:
Martina Poteti, Giulio Menegazzi, Silvia Peppicelli, Ignazia Tusa, Giulia Cheloni, Angela Silvano, Caterina Mancini, Alessio Biagioni, Alessandro Tubita, Nathalie M. Mazure, Matteo Lulli, Elisabetta Rovida, Persio Dello Sbarba
Publikováno v:
Cancers, Vol 13, Iss 17, p 4372 (2021)
This study was directed to characterize the role of glutamine in the modulation of the response of chronic myeloid leukemia (CML) cells to low oxygen, a main condition of hematopoietic stem cell niches of bone marrow. Cells were incubated in atmosphe
Externí odkaz:
https://doaj.org/article/308d0399c0214fa7a1dc4b10e96f418b
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 3, p 938 (2020)
The importance of mitogen-activated protein kinases (MAPK) in human pathology is underlined by the relevance of abnormalities of MAPK-related signaling pathways to a number of different diseases, including inflammatory disorders and cancer. One of th
Externí odkaz:
https://doaj.org/article/f82c562caae1464e9ba3d3ccecf5f7e8
Autor:
Angela Silvano, Giulio Menegazzi, Silvia Peppicelli, Caterina Mancini, Alessio Biagioni, Alessandro Tubita, Ignazia Tusa, Jessica Ruzzolini, Matteo Lulli, Elisabetta Rovida, Persio Dello Sbarba
Publikováno v:
Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics. 29:33-46
This study was directed to deepen the effects of nutrient shortage on BCR/Ablprotein expression and signaling in chronic myeloid leukemia (CML) cells. The backbone of the study was cell culture in medium lacking glucose, the consumption of which we h