Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Ignasi Roig"'
Autor:
Yan Huang, Ignasi Roig
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Meiosis is a specialized cell division that generates haploid gametes and is critical for successful sexual reproduction. During the extended meiotic prophase I, homologous chromosomes progressively pair, synapse and desynapse. These chromosomal dyna
Externí odkaz:
https://doaj.org/article/3ae57e2965ee4af0afdd7c40b9acd12d
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 17, p 9818 (2022)
Meiosis initiates with the formation of double strand breaks (DSBs) throughout the genome. To avoid genomic instability, these DSBs need to be correctly repaired by homologous recombination. Surveillance mechanisms involving the DNA damage response (
Externí odkaz:
https://doaj.org/article/d746a89f177d42468b6266ebad505ce6
Autor:
Ana Martínez-Marchal, Yan Huang, Maria Teresa Guillot-Ferriols, Mònica Ferrer-Roda, Anna Guixé, Montserrat Garcia-Caldés, Ignasi Roig
Publikováno v:
PLoS Genetics, Vol 16, Iss 11, p e1009067 (2020)
Mammalian oogonia proliferate without completing cytokinesis, forming cysts. Within these, oocytes differentiate and initiate meiosis, promoting double-strand break (DSBs) formation, which are repaired by homologous recombination (HR) causing the pai
Externí odkaz:
https://doaj.org/article/8b2a46aed27c47b08d7260ac4bd59782
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Homologous recombination ensures genome integrity during meiotic recombination. Here the authors reveal that factors SWS1 and SWSAP1 are critical for meiotic homologues recombination, particularly in promoting assembly of RAD51 and DMC1 on early reco
Externí odkaz:
https://doaj.org/article/fb252f8a69784ca2afef952f285a32f5
Autor:
Alexander Widger, Shantha K. Mahadevaiah, Julian Lange, Elias ElInati, Jasmin Zohren, Takayuki Hirota, Sarai Pacheco, Andros Maldonado-Linares, Marcello Stanzione, Obah Ojarikre, Valdone Maciulyte, Dirk G. de Rooij, Attila Tóth, Ignasi Roig, Scott Keeney, James M.A. Turner
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
ATR kinase is required for meiosis in non-mammalian model organisms. Here the authors demonstrate, using a tissue-specific knockout approach, that ATR is also essential for male meiosis in mouse, regulating meiotic recombination and synapsis.
Externí odkaz:
https://doaj.org/article/b92089ad88aa43c8bc4181f628f431ba
Autor:
Sarai Pacheco, Andros Maldonado-Linares, Marina Marcet-Ortega, Cristina Rojas, Ana Martínez-Marchal, Judit Fuentes-Lazaro, Julian Lange, Maria Jasin, Scott Keeney, Oscar Fernández-Capetillo, Montserrat Garcia-Caldés, Ignasi Roig
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
ATR kinase is required for meiosis in non-mammalian model organisms. Here the authors demonstrate, using a hypomorphic Atr mutation and chemical inhibition, that ATR is also essential for male meiosis in mouse, regulating meiotic recombination and sy
Externí odkaz:
https://doaj.org/article/fe3547f3e3bf408bb594225884c01810
Autor:
Laura Gómez-H, Natalia Felipe-Medina, Yazmine B Condezo, Rodrigo Garcia-Valiente, Isabel Ramos, José Angel Suja, José Luis Barbero, Ignasi Roig, Manuel Sánchez-Martín, Dirk G de Rooij, Elena Llano, Alberto M Pendas
Publikováno v:
PLoS Genetics, Vol 15, Iss 8, p e1008316 (2019)
The ubiquitin proteasome system regulates meiotic recombination in yeast through its association with the synaptonemal complex, a 'zipper'-like structure that holds homologous chromosome pairs in synapsis during meiotic prophase I. In mammals, the pr
Externí odkaz:
https://doaj.org/article/84914a7598074ee385fc28b2784651a2
Autor:
Marina Marcet-Ortega, Sarai Pacheco, Ana Martínez-Marchal, Helena Castillo, Elsa Flores, Maria Jasin, Scott Keeney, Ignasi Roig
Publikováno v:
PLoS Genetics, Vol 13, Iss 6, p e1006845 (2017)
To protect germ cells from genomic instability, surveillance mechanisms ensure meiosis occurs properly. In mammals, spermatocytes that display recombination defects experience a so-called recombination-dependent arrest at the pachytene stage, which r
Externí odkaz:
https://doaj.org/article/ceca357dc7794530839549303d069ae2
Publikováno v:
PLoS Genetics, Vol 11, Iss 3, p e1005017 (2015)
Most mutations that compromise meiotic recombination or synapsis in mouse spermatocytes result in arrest and apoptosis at the pachytene stage of the first meiotic prophase. Two main mechanisms are thought to trigger arrest: one independent of the dou
Externí odkaz:
https://doaj.org/article/0a8d9027b54845ff9a76ca50d5056d5d
Publikováno v:
PLoS Genetics, Vol 7, Iss 7, p e1002157 (2011)
The mammalian Cdkn2a (Ink4a-Arf) locus encodes two tumor suppressor proteins (p16(Ink4a) and p19(Arf)) that respectively enforce the anti-proliferative functions of the retinoblastoma protein (Rb) and the p53 transcription factor in response to oncog
Externí odkaz:
https://doaj.org/article/09fcc9981d644cb2b4c0136404152589