Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Ignasi Moran"'
Autor:
Goutham Atla, Silvia Bonàs-Guarch, Mirabai Cuenca-Ardura, Anthony Beucher, Daniel J. M. Crouch, Javier Garcia-Hurtado, Ignasi Moran, the T2DSystems Consortium, Manuel Irimia, Rashmi B. Prasad, Anna L. Gloyn, Lorella Marselli, Mara Suleiman, Thierry Berney, Eelco J. P. de Koning, Julie Kerr-Conte, Francois Pattou, John A. Todd, Lorenzo Piemonti, Jorge Ferrer
Publikováno v:
Genome Biology, Vol 23, Iss 1, Pp 1-28 (2022)
Abstract Background Non-coding genetic variants that influence gene transcription in pancreatic islets play a major role in the susceptibility to type 2 diabetes (T2D), and likely also contribute to type 1 diabetes (T1D) risk. For many loci, however,
Externí odkaz:
https://doaj.org/article/cf1281e02aac42cea7c15b4711ce5611
Autor:
Sílvia Bonàs-Guarch, Marta Guindo-Martínez, Irene Miguel-Escalada, Niels Grarup, David Sebastian, Elias Rodriguez-Fos, Friman Sánchez, Mercè Planas-Fèlix, Paula Cortes-Sánchez, Santi González, Pascal Timshel, Tune H. Pers, Claire C. Morgan, Ignasi Moran, Goutham Atla, Juan R. González, Montserrat Puiggros, Jonathan Martí, Ehm A. Andersson, Carlos Díaz, Rosa M. Badia, Miriam Udler, Aaron Leong, Varindepal Kaur, Jason Flannick, Torben Jørgensen, Allan Linneberg, Marit E. Jørgensen, Daniel R. Witte, Cramer Christensen, Ivan Brandslund, Emil V. Appel, Robert A. Scott, Jian’an Luan, Claudia Langenberg, Nicholas J. Wareham, Oluf Pedersen, Antonio Zorzano, Jose C Florez, Torben Hansen, Jorge Ferrer, Josep Maria Mercader, David Torrents
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Genome-wide association studies have uncovered several loci associated with diabetes risk. Here, the authors reanalyse public type 2 diabetes GWAS data to fine map 50 known loci and identify seven new ones, including one near ATGR2 on the X-chromosom
Externí odkaz:
https://doaj.org/article/bc0e732fc3984663bcd763ffc1af847e
Autor:
Sílvia Bonàs-Guarch, Marta Guindo-Martínez, Irene Miguel-Escalada, Niels Grarup, David Sebastian, Elias Rodriguez-Fos, Friman Sánchez, Mercè Planas-Fèlix, Paula Cortes-Sánchez, Santi González, Pascal Timshel, Tune H. Pers, Claire C. Morgan, Ignasi Moran, Goutham Atla, Juan R. González, Montserrat Puiggros, Jonathan Martí, Ehm A. Andersson, Carlos Díaz, Rosa M. Badia, Miriam Udler, Aaron Leong, Varindepal Kaur, Jason Flannick, Torben Jørgensen, Allan Linneberg, Marit E. Jørgensen, Daniel R. Witte, Cramer Christensen, Ivan Brandslund, Emil V. Appel, Robert A. Scott, Jian’an Luan, Claudia Langenberg, Nicholas J. Wareham, Oluf Pedersen, Antonio Zorzano, Jose C Florez, Torben Hansen, Jorge Ferrer, Josep Maria Mercader, David Torrents
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-2 (2018)
In the originally published version of this Article, the affiliation details for Santi González, Jian’an Luan and Claudia Langenberg were inadvertently omitted. Santi González should have been affiliated with 'Barcelona Supercomputing Center (BSC
Externí odkaz:
https://doaj.org/article/202ddca41ed244ff9a8f095f544c3220
Autor:
Martijn van de Bunt, Kyle J Gaulton, Leopold Parts, Ignasi Moran, Paul R Johnson, Cecilia M Lindgren, Jorge Ferrer, Anna L Gloyn, Mark I McCarthy
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e55272 (2013)
Recent advances in the understanding of the genetics of type 2 diabetes (T2D) susceptibility have focused attention on the regulation of transcriptional activity within the pancreatic beta-cell. MicroRNAs (miRNAs) represent an important component of
Externí odkaz:
https://doaj.org/article/508e515bb89a4eb388f2c718c1e93d44
Autor:
Marta Guindo-Martínez, Tõnu Esko, David Torrents, Alejandro Cáceres, Carlos Ruiz-Arenas, Josep M. Mercader, Marcos López-Sánchez, Juan R. González, Lorena Alonso, Luis A. Pérez-Jurado, Ignasi Moran, Josefa González, Ignacio Tolosana
Publikováno v:
Am J Hum Genet
Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC. Repositorio Institucional del CSIC
instname
The burden of several common diseases including obesity, diabetes, hypertension, asthma, and depression is increasing in most world populations. However, the mechanisms underlying the numerous epidemiological and genetic correlations among these diso
Autor:
François Pattou, Anthony Beucher, Julie Kerr-Conte, Ignasi Moran, Anna L. Gloyn, Cuenca-Ardura M, Jorge Ferrer, Javier García-Hurtado, Mara Suleiman, Koning EJPd, Thierry Berney, Irimia M, Lorenzo Piemonti, Goutham Atla, Rashmi B. Prasad, Bonas-Guarch S, Lorella Marselli
Genetic variants that influence transcriptional regulation in pancreatic islets play a major role in the susceptibility to type 2 diabetes (T2D). For many susceptibility loci, however, the mechanisms are unknown. We examined splicing QTLs (sQTLs) in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3882b92148c7020a8f696534632fb298
https://doi.org/10.1101/2021.11.11.468254
https://doi.org/10.1101/2021.11.11.468254
Autor:
Ji Chen, David Torrents, Goutham Atla, Lorena Alonso, Lorella Marselli, Montserrat Puiggròs, Jason M. Torres, Jorge Ferrer, Hindrik Mulder, Matthieu Defrance, Vibe Nylander, Marta Guindo-Martínez, Miriam Cnop, Decio L. Eizirik, Sílvia Bonàs-Guarch, Romina Royo, Mara Suleiman, Piero Marchetti, Jonathan L.S. Esguerra, Irene Miguel-Escalada, Josep M. Mercader, Ignasi Moran, Xavier Garcia-Hurtado, Anthony Piron, Leif Groop, Jean-Valery Turatsinze, Anna L. Gloyn, Ramon Amela, Lena Eliasson
GWAS have identified more than 700 genetic signals associated with type 2 diabetes (T2D). To gain insight into the underlying molecular mechanisms, we created the Translational human pancreatic Islet Genotype tissue-Expression Resource (TIGER), aggre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eec5544544aa3040601701a4f165b38f
https://doi.org/10.1101/2021.05.26.445616
https://doi.org/10.1101/2021.05.26.445616
Publikováno v:
Mathematics
Mathematics, Vol 9, Iss 3083, p 3083 (2021)
UPCommons. Portal del coneixement obert de la UPC
Universitat Politècnica de Catalunya (UPC)
Mathematics, Vol 9, Iss 3083, p 3083 (2021)
UPCommons. Portal del coneixement obert de la UPC
Universitat Politècnica de Catalunya (UPC)
The identification and characterisation of genomic changes (variants) that can lead to human diseases is one of the central aims of biomedical research. The generation of catalogues of genetic variants that have an impact on specific diseases is the
Autor:
Christopher Hartl, Katherine Tooley, Laura Riba, David Torrents, Ulises Alvirde, Olimpia Arellano-Campos, Ralph A. DeFronzo, Taru Tukiainen, Geoffrey A. Walford, Noël P. Burtt, Donna M. Lehman, Amy L. Williams, Alicia Huerta-Chagoya, Pierre Fontanillas, Richa Saxena, Stacey Gabriel, Michael Boehnke, Carlos A. Aguilar-Salinas, Stephan Ripke, Yayoi Segura-Kato, Steven A. McCarroll, Jacqueline M. Lane, Brian E. Henderson, Ravindranath Duggirala, Sobha Puppala, Ignasi Moran, Humberto García-Ortiz, Lizz Caulkins, María Elena González-Villalpando, Vineeta Agarwala, Maria L. Cortes, Jorge Ferrer, Cristina Revilla-Monsalve, Graeme I. Bell, Jason Flannick, Francisco Barajas-Olmos, María Luisa Ordóñez-Sánchez, Angélica Martínez-Hernández, Robert L. Hanson, Jose C. Florez, Broad Genomics Platform, Clicerio González-Villalpando, Ivette Cruz-Bautista, Rosario Rodríguez-Guillén, Sílvia Bonàs-Guarch, Rachel G. Liao, Lorena Orozco, Kathleen A. Jablonski, Daniel G. MacArthur, Elvia Mendoza-Caamal, Emilio J. Cordova, Karol Estrada, Hortensia Moreno-Macías, Leslie J. Baier, Avery Davis Bell, Hanna E. Abboud, Suzanne B.R. Jacobs, Maribel Rodriguez-Torres, Xavier Soberón, William C. Knowler, David Altshuler, Zachary Dymek, Christopher A. Haiman, Josep M. Mercader, Donaji V. Gómez-Velasco, Liliana Muñoz-Hernandez, Joanne E. Curran, Loic Le Marchand, Maegan Harden, Lynne R. Wilkens, John Blangero, Teresa Tusié-Luna, Federico Centeno-Cruz, Ling Chen, Craig L. Hanis, Carlos Zerrweck, Sergio Islas-Andrade, Cecilia Contreras-Cubas, Christopher P. Jenkinson
Publikováno v:
Diabetes. 66:2903-2914
Type 2 diabetes (T2D) affects more than 415 million people worldwide, and its costs to the health care system continue to rise. To identify common or rare genetic variation with potential therapeutic implications for T2D, we analyzed and replicated g
Autor:
Lorenzo Piemonti, Goutham Atla, Torben Hansen, Claire Morgan, Inês Cebola, Jorge Ferrer, Inga Prokopenko, Irene Farabella, Irene Miguel-Escalada, Marc A. Marti-Renom, Lorenzo Pasquali, Emil V. R. Appel, Niels Grarup, Javier García-Hurtado, Leif Groop, Josep M. Mercader, Eelco J.P. de Koning, Mireia Ramos-Rodríguez, Anette P. Gjesing, Delphine M.Y. Rolando, Allan Linneberg, Sílvia Bonàs-Guarch, François Pattou, Philippe Ravassard, Daniel R. Witte, Biola M. Javierre, Julie Kerr-Conte, Joan Ponsa-Cobas, David Torrents, Anthony Beucher, Peter Fraser, Thierry Berney, Iryna O. Fedko, Ole Birger Pedersen, Julen Mendieta-Esteban, Ignasi Moran
Publikováno v:
Nature Genetics
Nature Genetics, Nature Publishing Group, 2019, 51 (7), pp.1137-1148. ⟨10.1038/s41588-019-0457-0⟩
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
Nature Genetics, 51(7), 1137-1148. Nature Publishing Group
Nature Genetics, Vol. 51, No 7 (2019) pp. 1137-1148
Nature Genetics, 51(7), 1137-+. NATURE PUBLISHING GROUP
Miguel-Escalada, I, Bonàs-Guarch, S, Cebola, I, Ponsa-Cobas, J, Mendieta-Esteban, J, Atla, G, Javierre, B M, Rolando, D M Y, Farabella, I, Morgan, C C, García-Hurtado, J, Beucher, A, Morán, I, Pasquali, L, Ramos-Rodríguez, M, Appel, E V R, Linneberg, A, Gjesing, A P, Witte, D R, Pedersen, O, Grarup, N, Ravassard, P, Torrents, D, Mercader, J M, Piemonti, L, Berney, T, de Koning, E J P, Kerr-Conte, J, Pattou, F, Fedko, I O, Groop, L, Prokopenko, I, Hansen, T, Marti-Renom, M A, Fraser, P & Ferrer, J 2019, ' Human pancreatic islet three-dimensional chromatin architecture provides insights into the genetics of type 2 diabetes ', Nature Genetics, vol. 51, no. 7, pp. 1137-1148 . https://doi.org/10.1038/s41588-019-0457-0
Miguel-Escalada, I, Bonas-Guarch, S, Cebola, I, Ponsa-Cobas, J, Mendieta-Esteban, J, Atla, G, Javierre, B M, Rolando, D M Y, Farabella, I, Morgan, C C, Garcia-Hurtado, J, Beucher, A, Moran, I, Pasquali, L, Ramos-Rodriguez, M, Appel, E V R, Linneberg, A, Gjesing, A P, Witte, D R, Pedersen, O, Grarup, N, Ravassard, P, Torrents, D, Mercader, J M, Piemonti, L, Berney, T, de Koning, E J P, Kerr-Conte, J, Pattou, F, Fedko, I O, Groop, L, Prokopenko, I, Hansen, T, Marti-Renom, M A, Fraser, P & Ferrer, J 2019, ' Human pancreatic islet three-dimensional chromatin architecture provides insights into the genetics of type 2 diabetes ', Nature Genetics, vol. 51, no. 7, pp. 1137-1148 . https://doi.org/10.1038/s41588-019-0457-0
Nature Genetics, Nature Publishing Group, 2019, 51 (7), pp.1137-1148. ⟨10.1038/s41588-019-0457-0⟩
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
Nature Genetics, 51(7), 1137-1148. Nature Publishing Group
Nature Genetics, Vol. 51, No 7 (2019) pp. 1137-1148
Nature Genetics, 51(7), 1137-+. NATURE PUBLISHING GROUP
Miguel-Escalada, I, Bonàs-Guarch, S, Cebola, I, Ponsa-Cobas, J, Mendieta-Esteban, J, Atla, G, Javierre, B M, Rolando, D M Y, Farabella, I, Morgan, C C, García-Hurtado, J, Beucher, A, Morán, I, Pasquali, L, Ramos-Rodríguez, M, Appel, E V R, Linneberg, A, Gjesing, A P, Witte, D R, Pedersen, O, Grarup, N, Ravassard, P, Torrents, D, Mercader, J M, Piemonti, L, Berney, T, de Koning, E J P, Kerr-Conte, J, Pattou, F, Fedko, I O, Groop, L, Prokopenko, I, Hansen, T, Marti-Renom, M A, Fraser, P & Ferrer, J 2019, ' Human pancreatic islet three-dimensional chromatin architecture provides insights into the genetics of type 2 diabetes ', Nature Genetics, vol. 51, no. 7, pp. 1137-1148 . https://doi.org/10.1038/s41588-019-0457-0
Miguel-Escalada, I, Bonas-Guarch, S, Cebola, I, Ponsa-Cobas, J, Mendieta-Esteban, J, Atla, G, Javierre, B M, Rolando, D M Y, Farabella, I, Morgan, C C, Garcia-Hurtado, J, Beucher, A, Moran, I, Pasquali, L, Ramos-Rodriguez, M, Appel, E V R, Linneberg, A, Gjesing, A P, Witte, D R, Pedersen, O, Grarup, N, Ravassard, P, Torrents, D, Mercader, J M, Piemonti, L, Berney, T, de Koning, E J P, Kerr-Conte, J, Pattou, F, Fedko, I O, Groop, L, Prokopenko, I, Hansen, T, Marti-Renom, M A, Fraser, P & Ferrer, J 2019, ' Human pancreatic islet three-dimensional chromatin architecture provides insights into the genetics of type 2 diabetes ', Nature Genetics, vol. 51, no. 7, pp. 1137-1148 . https://doi.org/10.1038/s41588-019-0457-0
Genetic studies promise to provide insight into the molecular mechanisms underlying type 2 diabetes (T2D). Variants associated with T2D are often located in tissue-specific enhancer clusters or super-enhancers. So far, such domains have been defined
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7326164e1b7973796de54eaf5ccfc9e0
https://hal.archives-ouvertes.fr/hal-02408936
https://hal.archives-ouvertes.fr/hal-02408936