Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Ignas Gaska"'
Autor:
Md. Mydul Islam, Ignas Gaska, Oluwamayokun Oshinowo, Adiya Otumala, Shashank Shekhar, Nicholas Au Yong, David R. Myers
Publikováno v:
APL Bioengineering, Vol 8, Iss 3, Pp 036109-036109-12 (2024)
Pericytes line the microvasculature throughout the body and play a key role in regulating blood flow by constricting and dilating vessels. However, the biophysical mechanisms through which pericytes transduce microenvironmental chemical and mechanica
Externí odkaz:
https://doaj.org/article/eb032dd6eba84718b2b992ebb488c78c
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Cells control actin assembly by regulating reactions at actin filament barbed ends. Formins accelerate elongation, capping protein (CP) arrests growth and twinfilin promotes depolymerization at barbed ends. How these distinct activities get
Externí odkaz:
https://doaj.org/article/b17e2d7798d2442ca4dd67c8bb3540e5
Autor:
Tatyana Bodrug, Elizabeth M Wilson-Kubalek, Stanley Nithianantham, Alex F Thompson, April Alfieri, Ignas Gaska, Jennifer Major, Garrett Debs, Sayaka Inagaki, Pedro Gutierrez, Larisa Gheber, Richard J McKenney, Charles Vaughn Sindelar, Ronald Milligan, Jason Stumpff, Steven S Rosenfeld, Scott T Forth, Jawdat Al-Bassam
Publikováno v:
eLife, Vol 9 (2020)
Kinesin-5 motors organize mitotic spindles by sliding apart microtubules. They are homotetramers with dimeric motor and tail domains at both ends of a bipolar minifilament. Here, we describe a regulatory mechanism involving direct binding between tai
Externí odkaz:
https://doaj.org/article/df2534919cf44fd39e58c822475e8f4e
Autor:
Gary J. Brouhard, Scott Forth, Tatyana Bodrug, Larisa Gheber, Jawdat Al-Bassam, Jennifer Major, Steven S. Rosenfeld, Malina K. Iwanski, Himanshu Pandey, Adam G. Hendricks, Stanley Nithiananatham, Ignas Gaska, Sayaka Inagaki
The conserved kinesin-5 bipolar tetrameric motors slide apart microtubules during mitotic spindle assembly and elongation. Kinesin-5 bipolar organization originates from its conserved tetrameric helical minifilament, which position the C-terminal tai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e8c244382329a52af5e364281a56394d
https://doi.org/10.1101/2021.10.12.463902
https://doi.org/10.1101/2021.10.12.463902
Autor:
Ronald A. Milligan, Steven S. Rosenfeld, Garrett Debs, Larisa Gheber, Charles V. Sindelar, April Alfieri, Jawdat Al-Bassam, Jennifer Major, Ignas Gaska, Sayaka Inagaki, Pedro Gutierrez, Elizabeth M. Wilson-Kubalek, Stanley Nithianantham, Alex F. Thompson, Scott Forth, Richard J. McKenney, Tatyana Bodrug, Jason Stumpff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76cf8c0224bd6bc0193649d556198eb8
https://doi.org/10.7554/elife.51131.sa2
https://doi.org/10.7554/elife.51131.sa2
Publikováno v:
Curr Biol
The proper structural organization of the microtubule-based spindle during cell division requires the collective activity of many different types of proteins. These include non-motor microtubule-associated proteins (MAPs) whose functions include cros
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9407dd5cec5b0e7e7da7c73e9751ee7
https://doi.org/10.1016/j.cub.2021.03.034
https://doi.org/10.1016/j.cub.2021.03.034
Autor:
Pedro Gutierrez, April Alfieri, Jason Stumpff, Alex F. Thompson, Larisa Gheber, Garrett Debs, Jawdat Al-Bassam, Scott Forth, Ignas Gaska, Tatyana Bodrug, Sayaka Inagaki, Steven S. Rosenfeld, Elizabeth M. Wilson-Kubalek, Charles V. Sindelar, Jennifer Major, Richard J. McKenney, Ronald A. Milligan, Stanley Nithianantham
Publikováno v:
eLife
eLife, Vol 9 (2020)
eLife, Vol 9 (2020)
Kinesin-5 motors organize mitotic spindles by sliding apart microtubules. They are homotetramers with dimeric motor and tail domains at both ends of a bipolar minifilament. Here, we describe a regulatory mechanism involving direct binding between tai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1caba7112fd1c37d061824bd4cf3f9db
https://pubmed.ncbi.nlm.nih.gov/31958056
https://pubmed.ncbi.nlm.nih.gov/31958056
Autor:
Pedro Gutierrez, Larisa Gheber, Jawdat Al-Bassam, Stanley Nithianantham, Scott Forth, Alex F. Thompson, Elizabeth M. Wilson-Kubalek, Jason Stumpff, Ronald A. Milligan, Tatyana Bodrug, Steven S. Rosenfeld, Ignas Gaska, Sayaka Inagaki, Charles V. Sindelar, Jennifer Major, Richard J. McKenney, April Alfieri, Garrett Debs
Kinesin-5 motors organize mitotic spindles by sliding apart anti-parallel microtubules. They are homotetramers composed of two antiparallel dimers placing orthogonal motor and tail domains at opposite ends of a bipolar minifilament. Here, we describe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7caaee77135a6111fe64ec160abbdf45
Publikováno v:
SSRN Electronic Journal.
Cell division in eukaryotes requires the regulated assembly of the spindle apparatus. The proper organization of microtubules within the spindle is driven by motor proteins that exert forces to push and slide filaments, while non-motor proteins can c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eace3226beca4d1f97c5af8429b3daf7
https://doi.org/10.2139/ssrn.3481313
https://doi.org/10.2139/ssrn.3481313
Publikováno v:
Developmental Cell. 54:367-378.e5
Cell division in eukaryotes requires the regulated assembly of the spindle apparatus. The proper organization of microtubules within the spindle is driven by motor proteins that exert forces to slide filaments, whereas non-motor proteins crosslink fi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::914caa1be3c505fc416bf51d9745da7f
https://doi.org/10.1016/j.devcel.2020.06.017
https://doi.org/10.1016/j.devcel.2020.06.017