The Step-Wise C-Truncation and Transport of ESyt3 to Lipid Droplets Reveals a Mother Primordial Cisterna

Autor: Vasiliki S. Lalioti, Galina V. Beznoussenko, Alexander A. Mironov, Ignacio V. Sandoval

Extended synaptotagmins (E-Syts) are endoplasmic reticulum (ER) proteins consisting of an SMP domain and multiple C2 domains that bind phospholipids and Ca2+. E-Syts create contact junctions between the ER and plasma membrane to facilitate lipid exch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::55cca472e3df39f4f7de5ceb106b3591
https://doi.org/10.1101/2020.07.17.209122

Cdk5, the multifunctional surveyor

Autor: Ignacio V. Sandoval, Diego Pulido, Vassiliki Lalioti

Publikováno v: Cell Cycle. 9:284-311

Cyclin-dependent kinases (Cdks) are a family of proline-directed Ser/Thr kinases known for their role in the control of cell cycle progression. In 1992, this family was joined by Cdk5, which is an atypical member in that it uses its own activators an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4339f70ee9c32c185f704e99d3a4701e
https://doi.org/10.4161/cc.9.2.10466

The atypical kinase Cdk5 is activated by insulin, regulates the association between GLUT4 and E-Syt1, and modulates glucose transport in 3T3-L1 adipocytes

Autor: Vasiliki S. Lalioti, Ana Dinarina, Josef Van Damme, Joël Vandekerckhove, Gemma Muruais, Ignacio V. Sandoval

Publikováno v: Proceedings of the National Academy of Sciences. 106:4249-4253

Here, we report that Cdk5 activation is stimulated by insulin and plays a key role in the regulation of GLUT4-mediated glucose uptake in 3T3-L1 adipocytes. Insulin activation of Cdk5 requires PI3K signaling. Insulin-activated Cdk5 phosphorylates E-Sy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::793429083254fbb2429f62cbc3e03ef5
https://doi.org/10.1073/pnas.0900218106

ATP7B Copper-Regulated Traffic and Association With the Tight Junctions: Copper Excretion Into the Bile

Autor: Sonia García Hernández, Ignacio V. Sandoval, Yo Tsuchiya, Vassiliki Lalioti, Josefa Predestinación García Ruíz, Doris Cassio, Søren Nielsen

Publikováno v: Hernandez, S, Tsuchiya, Y, García-Ruiz, J P, Lalioti, V, Nielsen, S, Cassio, D & Sandoval, I V 2008, ' ATP7B copper-regulated traffic and association with the tight junctions: copper excretion into the bile ', Gastroenterology, vol. 134, no. 4, pp. 1215-23 . https://doi.org/10.1053/j.gastro.2008.01.043

Udgivelsesdato: 2008-Apr BACKGROUND & AIMS: The copper transporter ATP7B plays a central role in the elimination of excess copper by the liver into the bile, yet the site of its action remains controversial. The studies reported here examine the corr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daac43ba4f37d469f10c6e91f3403c6a
https://doi.org/10.1053/j.gastro.2008.01.043

Unifying Nomenclature for the Isoforms of the Lysosomal Membrane Protein LAMP-2

Autor: J. Fred Dice, Ichizo Nishino, Ana Maria Cuervo, Ignacio V. Sandoval, Eeva-Liisa Eskelinen, Paul Saftig, J. Thomas August, Matthew R.G. Taylor, Jennifer Lippincott-Schwartz, Janice S. Blum

Publikováno v: Traffic. 6:1058-1061

The present nomenclature of the splice variants of the lysosome-associated membrane protein type 2 (LAMP-2) is confusing. The LAMP-2a isoform is uniformly named in human, chicken, and mouse, but the LAMP-2b and LAMP-2c isoforms are switched in human

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5c08567d5c7ca1871464c1e7041dd778
https://doi.org/10.1111/j.1600-0854.2005.00337.x