Zobrazeno 1 - 10
of 108
pro vyhledávání: '"Ignacio Rego-Pérez"'
Autor:
Alejandro Durán-Sotuela, Jorge Vázquez-García, Sara Relaño-Fernández, Vanesa Balboa-Barreiro, Juan Fernández-Tajes, Francisco J. Blanco, Ignacio Rego-Pérez
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
BackgroundIn the context of the cytokine storm the takes place in severe COVID-19 patients, the Interleukin 6 (IL6) pathway emerges as one of the key pathways involved in the pathogenesis of this hyperinflammatory state. The strategy of blocking the
Externí odkaz:
https://doaj.org/article/73e55356c705455a8df2e1540d8ca9f8
Autor:
Maite Silva-Díaz, Sonia Pértega-Díaz, Vanesa Balboa-Barreiro, Carlos M. Tilve-Álvarez, Ana Raga-Sivira, Ignacio Rego-Pérez, Francisco J. Blanco, Natividad Oreiro
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract To delineate the phenotype of erosive hand osteoarthritis (EHOA) in a Spanish population and assess its correlation with metabolic syndrome. We conducted a cross-sectional study using baseline data from the Prospective Cohort of Osteoarthrit
Externí odkaz:
https://doaj.org/article/220acdcf45f74a1d977a80ceccbac355
Autor:
Andrea Dalmao-Fernández, Tamara Hermida-Gómez, Uxia Nogueira-Recalde, Ignacio Rego-Pérez, Francisco J. Blanco-Garcia, Mercedes Fernández-Moreno
Publikováno v:
Cells, Vol 13, Iss 11, p 976 (2024)
Authors have demonstrated that apoptosis activation is a pathway related to cartilage degradation characteristics of the OA process. Autophagy is an adaptive response to protect cells from various environmental changes, and defects in autophagy are l
Externí odkaz:
https://doaj.org/article/2e366a3d4f1a4af881a11ff6f50791b6
Autor:
Hossein Bonakdari, Jean-Pierre Pelletier, Francisco J. Blanco, Ignacio Rego-Pérez, Alejandro Durán-Sotuela, Dawn Aitken, Graeme Jones, Flavia Cicuttini, Afshin Jamshidi, François Abram, Johanne Martel-Pelletier
Publikováno v:
BMC Medicine, Vol 20, Iss 1, Pp 1-16 (2022)
Abstract Background Knee osteoarthritis is the most prevalent chronic musculoskeletal debilitating disease. Current treatments are only symptomatic, and to improve this, we need a robust prediction model to stratify patients at an early stage accordi
Externí odkaz:
https://doaj.org/article/c7c9c44f29fc4081a8ba1bf061d04e74
Autor:
Paula Ramos-Louro, Rubén Daniel Arellano Pérez Vertti, Alberto López Reyes, Gabriela Angélica Martínez-Nava, Rolando Espinosa, Carlos Pineda, Faviel Francisco González Galarza, Rafael Argüello Astorga, Lizette Sarai Aguilar Muñiz, Fernando Hernández Terán, Nancy Marbella Parra Torres, Alejandro Durán Sotuela, Mercedes Fernández-Moreno, Vanesa Balboa Barreiro, Francisco J. Blanco, Ignacio Rego-Pérez
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract To evaluate the influence of mitochondrial DNA haplogroups on the risk of knee OA in terms of their interaction with obesity, in a population from Mexico. Samples were obtained from (n = 353) knee OA patients (KL grade ≥ I) and (n = 364) h
Externí odkaz:
https://doaj.org/article/2895add6e1584604b5688fb9d56428bb
Autor:
Rebeca Guillén, Fátima Otero, Alejandro Mosquera, María Vázquez-Mosquera, Ignacio Rego-Pérez, Francisco J. Blanco, José Luis Fernández
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-6 (2021)
Abstract Osteoarthritis (OA) is a chronic degenerative joint disease, being the main cause of laboral inability. Decreased telomere size in peripheral blood leukocytes (PBL) has been correlated with age-related pathologies, like knee OA. In a dynamic
Externí odkaz:
https://doaj.org/article/8e926419c1224bec83ec03591667d294
Autor:
Morena Scotece, Ignacio Rego-Pérez, Ana Victoria Lechuga-Vieco, Alberto Centeno Cortés, María Concepción Jiménez-Gómez, Purificación Filgueira-Fernández, Carlos Vaamonde-García, José Antonio Enríquez, Francisco J. Blanco
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract It has been suggested that mitochondrial dysfunction and mtDNA variations may contribute to osteoarthritis (OA) pathogenesis. However, the causative link to support this claim is lacking. Here, we surgically-induced OA in conplastic mice in
Externí odkaz:
https://doaj.org/article/b5574bd366dc4090abea5086ff794bf4
Autor:
Maria Eugenia Vázquez-Mosquera, Mercedes Fernández-Moreno, Estefanía Cortés-Pereira, Sara Relaño, Andrea Dalmao-Fernández, Paula Ramos-Louro, Alejandro Durán Sotuela, Ignacio Rego-Pérez, Francisco J. Blanco
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
The association between obesity and osteoarthritis (OA) in joints not subjected to mechanical overload, together with the relationship between OA and metabolic syndrome, suggests that there are systemic factors related to metabolic disorders that are
Externí odkaz:
https://doaj.org/article/5fc3f10828eb4233bea4bc2c341ecac7
Publikováno v:
Frontiers in Genetics, Vol 10 (2020)
During recent years, the significant influence of mitochondria on osteoarthritis (OA), the most common joint disease, has been consistently demonstrated. Not only mitochondrial dysfunction but also mitochondrial genetic polymorphisms, specifically th
Externí odkaz:
https://doaj.org/article/efe3c13fc2da40d7b56415190464af9f
Autor:
Francisco J. Blanco, María Camacho-Encina, Lucía González-Rodríguez, Ignacio Rego-Pérez, Jesús Mateos, Patricia Fernández-Puente, Lucía Lourido, Beatriz Rocha, Florencia Picchi, María T. Silva-Díaz, Marta Herrero, Helena Martínez, Josep Verges, Cristina Ruiz-Romero, Valentina Calamia
Publikováno v:
Therapeutic Advances in Chronic Disease, Vol 10 (2019)
Background: In the present study, we explored potential protein biomarkers useful to predict the therapeutic response of knee osteoarthritis (KOA) patients treated with pharmaceutical grade Chondroitin sulfate/Glucosamine hydrochloride (CS+GH; Drogli
Externí odkaz:
https://doaj.org/article/af8e183535eb4406bf0b42757be445d6