Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Ignacio Norambuena‐Soto"'
Autor:
Nicolas Herrera-Zelada, Úrsula Zúñiga-Cuevas, Andrés Ramírez-Reyes, Ignacio Norambuena-Soto, Leslye Venegas-Zamora, Mayarling F. Troncoso, Alejandra Hernández, Gina Sánchez, Zully Pedrozo, Sergio Lavandero, Jaime A. Riquelme
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Small extracellular vesicles are nanosized vesicles (30–200 nm) that can ferry proteins, nucleic acids, and lipids between cells and therefore, have significant potential as biomarkers, drug delivery tools or therapeutic agents. SEVs of endothelial
Externí odkaz:
https://doaj.org/article/831361ba889740838558f0ef5b568c11
Autor:
Pablo Sánchez-Aguilera, Camila López-Crisosto, Ignacio Norambuena-Soto, Christian Penannen, Jumo Zhu, Nils Bomer, Matijn F. Hoes, Peter Van Der Meer, Mario Chiong, B. Daan Westenbrink, Sergio Lavandero
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
A physiological increase in cardiac workload results in adaptive cardiac remodeling, characterized by increased oxidative metabolism and improvements in cardiac performance. Insulin-like growth factor-1 (IGF-1) has been identified as a critical regul
Externí odkaz:
https://doaj.org/article/dd5985a3229f44acb011a62b508ee8b7
Autor:
Fernanda Sanhueza-Olivares, Mayarling F. Troncoso, Francisco Pino-de la Fuente, Javiera Martinez-Bilbao, Jaime A. Riquelme, Ignacio Norambuena-Soto, Monica Villa, Sergio Lavandero, Pablo F. Castro, Mario Chiong
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Heart failure with preserved ejection fraction (HFpEF) is one of the most complex and most prevalent cardiometabolic diseases in aging population. Age, obesity, diabetes, and hypertension are the main comorbidities of HFpEF. Microvascular dysfunction
Externí odkaz:
https://doaj.org/article/ba2054dc6fed47969814acdf6a2b16ff
Autor:
Paulina Villar-Fincheira, Aaron J. Paredes, Tomás Hernández-Díaz, Ignacio Norambuena-Soto, Nicole Cancino-Arenas, Fernanda Sanhueza-Olivares, Felipe Contreras-Briceño, Jorge Mandiola, Nicole Bruneau, Lorena García, María Paz Ocaranza, Rodrigo Troncoso, Luigi Gabrielli, Mario Chiong
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Little is known about the effects of training load on exercise-induced plasma increase of interleukin-6 (IL-6) and soluble IL-6 receptor (sIL-6R) and their relationship with vascular remodeling. We sought to evaluate the role of sIL 6R as a regulator
Externí odkaz:
https://doaj.org/article/30591f36357147439c19e17f73b57cff
Autor:
Paulina Villar-Fincheira, Fernanda Sanhueza-Olivares, Ignacio Norambuena-Soto, Nicole Cancino-Arenas, Felipe Hernandez-Vargas, Rodrigo Troncoso, Luigi Gabrielli, Mario Chiong
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
IL-6 is usually described as a pleiotropic cytokine produced in response to tissue injury or infection. As a pro-inflammatory cytokine, IL-6 activates innate and adaptative immune responses. IL-6 is released in the innate immune response by leukocyte
Externí odkaz:
https://doaj.org/article/b5752610191041db830853943d3839c9
Autor:
David Mondaca-Ruff, Jaime A. Riquelme, Clara Quiroga, Ignacio Norambuena-Soto, Fernanda Sanhueza-Olivares, Paulina Villar-Fincheira, Tomás Hernández-Díaz, Nicole Cancino-Arenas, Alejandra San Martin, Lorena García, Sergio Lavandero, Mario Chiong
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2019)
Hypertension is a disease associated to increased plasma levels of angiotensin II (Ang II). Ang II can regulate proliferation, migration, ROS production and hypertrophy of vascular smooth muscle cells (VSMCs). However, the mechanisms by which Ang II
Externí odkaz:
https://doaj.org/article/27a1269233424edf91bfb0926a375cc7
Autor:
Marina García-Miguel, Jaime A Riquelme, Ignacio Norambuena-Soto, Pablo E Morales, Fernanda Sanhueza-Olivares, Constanza Nuñez-Soto, David Mondaca-Ruff, Nicole Cancino-Arenas, Alejandra San Martín, Mario Chiong
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0197210 (2018)
Vascular smooth muscle cells (VSMC) dedifferentiation from a contractile to a synthetic phenotype contributes to atherosclerosis. Atherosclerotic tissue has a chronic inflammatory component with high levels of tumor necrosis factor-α (TNF-α). VSMC
Externí odkaz:
https://doaj.org/article/b0d6e8556f054aa1bafd24fa673ae7c3
Autor:
Ximena Calle, Valeria Garrido‐Moreno, Erik Lopez‐Gallardo, Ignacio Norambuena‐Soto, Daniela Martínez, Allan Peñaloza‐Otárola, Angelo Troncossi, Alejandra Guerrero‐Moncayo, Angélica Ortega, Vinicius Maracaja‐Coutinho, Valentina Parra, Mario Chiong, Sergio Lavandero
Publikováno v:
IUBMB lifeREFERENCES. 74(9)
Mitochondrial E3 ubiquitin ligase 1 (MUL1) is a mitochondrial outer membrane-anchored protein-containing transmembrane domain in its N- and C-terminal regions, where both are exposed to the cytosol. Interestingly the C-terminal region has a RING fing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e1630456135c3afffdb132c108d51c1
https://pubmed.ncbi.nlm.nih.gov/35638168
https://pubmed.ncbi.nlm.nih.gov/35638168
Autor:
David Mondaca‐Ruff, Clara Quiroga, Ignacio Norambuena‐Soto, Jaime A. Riquelme, Alejandra San Martin, Mario Bustamante, Sergio Lavandero, Mario Chiong
Publikováno v:
Journal of cellular and molecular medicine. 26(5)
Hypertension is associated with high circulating angiotensin II (Ang II). We have reported that autophagy regulates Ang II-induced vascular smooth muscle cell (VSMC) hypertrophy, but the mechanism mediating this effect is still unknown. Therefore, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a3949571657d0603d659d804e20de9c
https://pubmed.ncbi.nlm.nih.gov/35118791
https://pubmed.ncbi.nlm.nih.gov/35118791
Autor:
Ignacio Norambuena-Soto, Camila Lopez-Crisosto, Javiera Martinez-Bilbao, Carolina Hernandez-Fuentes, Valentina Parra, Sergio Lavandero, Mario Chiong
Publikováno v:
Biochemical Pharmacology. 203:115183
Angiotensin-(1-9) [Ang-(1-9)] is a peptide of the non-canonical renin-angiotensin system (RAS) synthesized from angiotensin I by the monopeptidase angiotensin-converting enzyme type 2 (ACE2). Using osmotic minipumps, infusion of Ang-(1-9) consistentl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e445c08975ce5870581735505aed746d
https://doi.org/10.1016/j.bcp.2022.115183
https://doi.org/10.1016/j.bcp.2022.115183