Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Ignacio Niechi"'
Autor:
Cristopher Almarza, Karla Villalobos-Nova, María A. Toro, Manuel González, Ignacio Niechi, David A. Brown‑Brown, Rodrigo A. López-Muñoz, Eduardo Silva-Pavez, Belén Gaete-Ramírez, Manuel Varas-Godoy, Verónica A. Burzio, Lilian Jara, Francisco Aguayo, Julio C. Tapia
Publikováno v:
Biological Research, Vol 57, Iss 1, Pp 1-12 (2024)
Abstract Background Lung cancer constitutes the leading cause of cancer mortality. High levels of endothelin-1 (ET-1), its cognate receptor ETAR and its activating enzyme, the endothelin-converting enzyme-1 (ECE-1), have been reported in several canc
Externí odkaz:
https://doaj.org/article/0cf4339a416b4966826e5c5eb699c312
Autor:
Francisco Rodas, Jetzabel A. Vidal-Vidal, Daniela Herrera, David A. Brown-Brown, Diego Vera, Joaquín Veliz, Pilar Püschel, José I. Erices, Verónica Sánchez Hinojosa, Julio C. Tapia, Eduardo Silva-Pavez, Claudia Quezada-Monrás, Pablo Mendoza-Soto, Flavio Salazar-Onfray, Cristian Carrasco, Ignacio Niechi
Publikováno v:
Cancer Cell International, Vol 23, Iss 1, Pp 1-13 (2023)
Abstract Background Gallbladder cancer (GBC) is a prevalent and deadly biliary tract carcinoma, often diagnosed at advanced stages with limited treatment options. The 5-year survival rate varies widely from 4 to 60%, mainly due to differences in dise
Externí odkaz:
https://doaj.org/article/dbab4179d4a748d7bef2277a241ba50f
Autor:
Ignacio Niechi, Jose R. Pineda
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Externí odkaz:
https://doaj.org/article/c520eb91f494423f81da7aaec271a069
Autor:
José I. Erices, Ignacio Niechi, Atenea Uribe-Ojeda, María de los Ángeles Toro, Noemí García-Romero, Josefa Carrión-Navarro, Álvaro Monago-Sánchez, Ángel Ayuso-Sacido, Rody San Martin, Claudia Quezada-Monrás
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Glioblastoma (GBM) is the most common and deadly malignant brain tumor, with a median survival of 15 to 17 months for a patient. GBM contains a cellular subpopulation known as GBM stem-like cells (GSCs) that persist in hypoxic niches and are capable
Externí odkaz:
https://doaj.org/article/a4997a619ad3488384a3bdfbb2d5d6f6
Autor:
José Ignacio Erices, Carolina Bizama, Ignacio Niechi, Daniel Uribe, Arnaldo Rosales, Karen Fabres, Giovanna Navarro-Martínez, Ángelo Torres, Rody San Martín, Juan Carlos Roa, Claudia Quezada-Monrás
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 8, p 7047 (2023)
Glioblastoma (GBM) is the most common and malignant primary brain cancer in adults. Without treatment the mean patient survival is approximately 6 months, which can be extended to 15 months with the use of multimodal therapies. The low effectiveness
Externí odkaz:
https://doaj.org/article/c1aad6dc38064feaa2c4f4fa59af19bf
Autor:
Pablo Pérez‐Moreno, Sebastián Indo, Ignacio Niechi, Hernán Huerta, Pablo Cabello, Lilian Jara, Francisco Aguayo, Manuel Varas‐Godoy, Verónica A. Burzio, Julio C. Tapia
Publikováno v:
Molecular Oncology, Vol 14, Iss 2, Pp 347-362 (2020)
Endothelin‐1 is a mitogenic peptide that activates several proliferation, survival, and invasiveness pathways. The effects of endothelin‐1 rely on its activation by endothelin‐converting enzyme‐1 (ECE1), which is expressed as four isoforms wi
Externí odkaz:
https://doaj.org/article/18a70dfd7d844727ac173a958ee71a6a
Autor:
Ignacio Niechi, José I. Erices, Diego Carrillo-Beltrán, Atenea Uribe-Ojeda, Ángelo Torres, José Dellis Rocha, Daniel Uribe, María A. Toro, Karla Villalobos-Nova, Belén Gaete-Ramírez, Gabriel Mingo, Gareth I. Owen, Manuel Varas-Godoy, Lilian Jara, Francisco Aguayo, Verónica A. Burzio, Claudia Quezada-Monrás, Julio C. Tapia
Publikováno v:
Cells, Vol 12, Iss 3, p 506 (2023)
Glioblastoma (GBM) is the most common and aggressive type of brain tumor due to its elevated recurrence following treatments. This is mainly mediated by a subpopulation of cells with stemness traits termed glioblastoma stem-like cells (GSCs), which a
Externí odkaz:
https://doaj.org/article/8da72235487e4ae7911a3687cf588995
Autor:
José-Dellis Rocha, Daniel Uribe, Javiera Delgado, Ignacio Niechi, Sebastián Alarcón, José Ignacio Erices, Rómulo Melo, Rodrigo Fernández-Gajardo, Flavio Salazar-Onfray, Rody San Martín, Claudia Quezada Monrás
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 16, p 9022 (2022)
Glioblastoma is the most common and aggressive primary brain tumor, characterized by its high chemoresistance and the presence of a cell subpopulation that persists under hypoxic niches, called glioblastoma stem-like cells (GSCs). The chemoresistance
Externí odkaz:
https://doaj.org/article/5dfddc43e2704698ade033fd7cb97f90
Autor:
Pablo Pérez-Moreno, Camila Quezada-Meza, Cristopher Chavez-Almarza, Ignacio Niechi, Eduardo Silva-Pavez, César Trigo-Hidalgo, Francisco Aguayo, Lilian Jara, Albano Cáceres-Verschae, Manuel Varas-Godoy, Víctor M. Díaz, Antonio García de Herreros, Verónica A. Burzio, Julio C. Tapia
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Endothelin-converting enzyme-1 (ECE1) activates the endothelin-1 peptide, which upregulates pathways that are related to diverse hallmarks of cancer. ECE1 is expressed as four isoforms differing in their N-terminal domains. Protein kinase CK2 phospho
Externí odkaz:
https://doaj.org/article/c5d15211b6f741cbb97cf35bac2c6ec9
Autor:
Daniel Uribe, Ignacio Niechi, Gorjana Rackov, José I. Erices, Rody San Martín, Claudia Quezada
Publikováno v:
Biology, Vol 11, Iss 2, p 313 (2022)
Glioblastoma (GBM) is the most frequent and aggressive brain tumor, characterized by great resistance to treatments, as well as inter- and intra-tumoral heterogeneity. GBM exhibits infiltration, vascularization and hypoxia-associated necrosis, charac
Externí odkaz:
https://doaj.org/article/8feccdb1efa1477bb3fc38fa24658cb0