Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Ignacio Manzanares"'
Autor:
Plácido A. Ceballos, Carmen Cuevas, Andrés Francesch, Ignacio Manzanares, Antonio M. Echavarren, Marta Pérez
Publikováno v:
European Journal of Organic Chemistry. 2006:1926-1933
Phthalimido derivatives of cyanosafracin B have been synthesized as analogues of the antitumor agent ecteinascidin 743. As part of this study, a quinoneimine has been prepared, which is a kinetically stable tautomer of a 5-hydroxyindole. This quinone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::447b8d542e66e639a0f0528a3a697a83
https://doi.org/10.1002/ejoc.200500882
https://doi.org/10.1002/ejoc.200500882
Autor:
Andrés Francesch, Pedro Molina, Carmen Cuevas, Pilar M. Fresneda, Santiago Delgado, Ignacio Manzanares
Publikováno v:
Journal of Medicinal Chemistry. 49:1217-1221
The marine alkaloid variolin B 2 and eight synthetic derivatives with different substituents at positions C-5 and C-7 have been tested in a panel of sixteen human tumor cell lines to evaluate their cytotoxic potential.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2431e64bf8511b033f072c106d39d886
https://doi.org/10.1021/jm051090r
https://doi.org/10.1021/jm051090r
Autor:
Marta Gutiérrez-Rodríguez, Miguel Feliz, M. Teresa García-López, Ernest Giralt, Ignacio Manzanares, Felix Cuevas, Rosario Herranz, Mercedes Martín-Martínez, Concepcion Polanco, Ignacio Rodriguez-Campos, Paul Lloyd-Williams, Francisco Cardenas
Publikováno v:
Journal of Medicinal Chemistry. 47:5700-5712
With the aim of studying the contribution of the beta II turn conformation at the side chain of didemnins to the bioactive conformation responsible for their antitumoral activity, conformationally restricted analogues of aplidine and tamandarin A, wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1011372bbf0732d61e0dce64444252db
https://doi.org/10.1021/jm040788m
https://doi.org/10.1021/jm040788m
Autor:
José A Jiménez, Alfredo Pastor, Andrés Francesch, Ignacio Manzanares, Brigitte Baldeyrou, Cristina Mateo, Carmen Cuevas, Christian Bailly, William Laine, Dolores Garcı́a-Gravalos, Michael Facompré, Christelle Tardy
Publikováno v:
Bioorganic & Medicinal Chemistry. 12:1697-1712
The marine alkaloid lamellarin D (LAM-D) has been recently characterized as a potent poison of human topoisomerase I endowed with remarkable cytotoxic activities against tumor cells. We report here the first structure-activity relationship study in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0512f6d1112d0cd498af3311148af481
https://doi.org/10.1016/j.bmc.2004.01.020
https://doi.org/10.1016/j.bmc.2004.01.020
Autor:
Juan J. Vaquero, Carolina Burgos, Federico Gago, Carmen Cuevas, Alberto Domingo, Raquel Garcı́a-Nieto, Gerónimo Fernández, Julio Alvarez-Builla, Ignacio Manzanares, Valentin Martinez
Publikováno v:
Journal of Medicinal Chemistry. 47:1136-1148
New azaquinolizinium-type cations have been obtained from isochromane. The synthesis was completed over seven steps and included as the key feature an intramolecular Westphal condensation. This first example of the intramolecular process allowed the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::997c7f8fb707832dea842eea122576d7
https://doi.org/10.1021/jm0310434
https://doi.org/10.1021/jm0310434
Autor:
David Fernandez, Gerardo Danelon, Abderaouf Ahaidar, Ignacio Manzanares, Carmen Cuevas, Mercedes Alvarez, Fernando Albericio, John A. Joule
Publikováno v:
The Journal of Organic Chemistry. 68:10020-10029
Two alternative synthetic routes have been developed for the preparation of variolin B and deoxyvariolin B. The strategy is based on the preparation of the core tricyclic ring common to all variolins, pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidine, follow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::762dd561f7ead6c3e99f98de4c97175c
https://doi.org/10.1021/jo035332b
https://doi.org/10.1021/jo035332b
Publikováno v:
Scopus-Elsevier
The stereochemistry of the amino acids in the marine-derived cyclic depsipeptide kahalalide F has been defined by a series of degradation reactions (hydrolysis, ozonolysis, Edman degradation, and Marfey derivatization), yielding smaller fragments of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6c291aae8c8e9557545d66154ce14fc
https://doi.org/10.1021/np030334c
https://doi.org/10.1021/np030334c
Autor:
David Fernandez, Fernando Albericio, Gerardo Danelon, Ignacio Manzanares, Abderaouf Ahaidar, Carmen Cuevas, Olga Gloria Barbón Pérez, John A. Joule, Mercedes Alvarez
Publikováno v:
Tetrahedron Letters. 44:6191-6194
The total synthesis of variolin B from 4-methoxy-7-azaindole is described. The preparation of the protected amino derivative 10 and a coupling reaction of the iodo derivative 12 with 2-acetylamino-4-trimethylstannylpyrimidine are the key steps of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c18dd1e983c94ee714d104a82d8f9cfe
https://doi.org/10.1016/s0040-4039(03)01551-x
https://doi.org/10.1016/s0040-4039(03)01551-x
Publikováno v:
Organic Letters. 5:2959-2962
[reaction: see text] A total solid-phase synthesis of lamellarins U and L has been achieved. The conversion of an aldehyde group into a formate by a Baeyer-Villiger reaction and a intramolecular [3 + 2] cycloaddition of a 3,4-dihydroisoquinolinium sa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a4ee459f8a469e2af06da90b33abc4e
https://doi.org/10.1021/ol0351192
https://doi.org/10.1021/ol0351192
Autor:
Ignacio Manzanares, Jesús Mendieta, Carmen Cuevas, Federico Gago, Esther Marco, Raquel Garcı́a-Nieto
Publikováno v:
Journal of Medicinal Chemistry. 45:871-880
The antitumor ecteinascidin ET743 has been shown to inhibit the transcriptional activation of a number of genes at nanomolar concentrations. Cell sensitivity to subnanomolar concentrations of the drug has also been shown to specifically depend on the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24ea47ab7f1ab985b77ab44b3ffef755
https://doi.org/10.1021/jm010370d
https://doi.org/10.1021/jm010370d