Výsledky vyhledávání - "Ignacio Lizasoain"

Akademický článek

Immune dysregulation is an important factor in the underlying complications in Influenza infection. ApoH, IL-8 and IL-15 as markers of prognosis

Autor: Sara Garcinuño, Antonio Lalueza, Francisco Javier Gil-Etayo, Raquel Díaz-Simón, Ignacio Lizasoain, Ana Moraga, Blanca Diaz-Benito, Laura Naranjo, Oscar Cabrera-Marante, Daniel Enrique Pleguezuelo, Maria Ruiz-Ruigomez, Blanca Ayuso, Estibaliz Arrieta, Dolores Folgueira, Estela Paz-Artal, Cecilia Cueto, Carlos Lumbreras, Antonio Serrano, Manuel Serrano

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

IntroductionInfluenza virus infection can cause a range of clinical symptoms, including respiratory failure (RF) and even death. The mechanisms responsible for the most severe forms of the disease are not yet well understood. The objective is to asse

Externí odkaz: https://doaj.org/article/a11bb4784f4e45ccaa37f9348df97030

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Akademický článek

Endothelial cells regulate astrocyte to neural progenitor cell trans-differentiation in a mouse model of stroke

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)

Damaged brains try to repair themselves by producing neurons in areas where neurogenesis does not normally occur. Here, the authors show that brain endothelial cells provide microvesicle-encased signals that convert parenchymal astrocytes into neural

Externí odkaz: https://doaj.org/article/f63343dfedd9439ab7c83ba7559d3566

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Akademický článek

Defective hippocampal neurogenesis underlies cognitive impairment by carotid stenosis-induced cerebral hypoperfusion in mice

Autor: Enrique Fraga, Violeta Medina, María Isabel Cuartero, Alicia García-Culebras, Isabel Bravo-Ferrer, Macarena Hernández-Jiménez, Juan Manuel Garcia-Segura, Olivia Hurtado, Jesus Miguel Pradillo, Ignacio Lizasoain, María Ángeles Moro

Publikováno v: Frontiers in Cellular Neuroscience, Vol 17 (2023)

Chronic cerebral hypoperfusion due to carotid artery stenosis is a major cause of vascular cognitive impairment and dementia (VCID). Bilateral carotid artery stenosis (BCAS) in rodents is a well-established model of VCID where most studies have focus

Externí odkaz: https://doaj.org/article/a70bfd65a6b34e31a916d9dd24755df3

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Akademický článek

Saturated fatty acid-enriched small extracellular vesicles mediate a crosstalk inducing liver inflammation and hepatocyte insulin resistance

Autor: Irma Garcia-Martinez, Rosa Alen, Laura Pereira, Adrián Povo-Retana, Alma M. Astudillo, Ana B. Hitos, Isabel Gomez-Hurtado, Eduardo Lopez-Collazo, Lisardo Boscá, Rubén Francés, Ignacio Lizasoain, María Ángeles Moro, Jesús Balsinde, Manuel Izquierdo, Ángela M. Valverde

Publikováno v: JHEP Reports, Vol 5, Iss 8, Pp 100756- (2023)

Background & Aims: Lipotoxicity triggers non-alcoholic fatty liver disease (NAFLD) progression owing to the accumulation of toxic lipids in hepatocytes including saturated fatty acids (SFAs), which activate pro-inflammatory pathways. We investigated

Externí odkaz: https://doaj.org/article/976cfcba75f4439397449d4932f399d3

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Akademický článek

First-in-human phase I clinical trial of a TLR4-binding DNA aptamer, ApTOLL: Safety and pharmacokinetics in healthy volunteers

Autor: Macarena Hernández-Jiménez, Samuel Martín-Vílchez, Dolores Ochoa, Gina Mejía-Abril, Manuel Román, Paola Camargo-Mamani, Sergio Luquero-Bueno, Bernd Jilma, María A. Moro, Gerónimo Fernández, David Piñeiro, Marc Ribó, Víctor M. González, Ignacio Lizasoain, Francisco Abad-Santos

Publikováno v: Molecular Therapy: Nucleic Acids, Vol 28, Iss , Pp 124-135 (2022)

ApTOLL is an aptamer that antagonizes Toll-like receptor 4 and improves functional outcomes in models of ischemic stroke and myocardial infarction. The aim of this study was to characterize the safety and pharmacokinetics of ApTOLL in healthy volunte

Externí odkaz: https://doaj.org/article/1d6415b299c844c7bc5d3c6a71847c5b

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Akademický článek

Insulin receptor activation by proinsulin preserves synapses and vision in retinitis pigmentosa

Autor: Alonso Sánchez-Cruz, Alberto Hernández-Pinto, Concepción Lillo, Carolina Isiegas, Miguel Marchena, Ignacio Lizasoain, Fátima Bosch, Pedro de la Villa, Catalina Hernández-Sánchez, Enrique J. de la Rosa

Publikováno v: Cell Death and Disease, Vol 13, Iss 4, Pp 1-14 (2022)

Abstract Synaptic loss, neuronal death, and circuit remodeling are common features of central nervous system neurodegenerative disorders. Retinitis pigmentosa (RP), the leading cause of inherited blindness, is a group of retinal dystrophies character

Externí odkaz: https://doaj.org/article/b5a24d26701d467ea1eb4c14c34571c4

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