Zobrazeno 1 - 10
of 1 665
pro vyhledávání: '"Ignacio I. Wistuba"'
Autor:
Chenyang Li, Thinh T. Nguyen, Jian-Rong Li, Xingzhi Song, Junya Fujimoto, Latasha Little, Curtis Gumb, Chi-Wan B. Chow, Ignacio I. Wistuba, Andrew P. Futreal, Jianhua Zhang, Shawna M. Hubert, John V. Heymach, Jia Wu, Christopher I. Amos, Jianjun Zhang, Chao Cheng
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-14 (2024)
Abstract Lung Cancer remains the leading cause of cancer deaths in the USA and worldwide. Non-small cell lung cancer (NSCLC) harbors high transcriptomic intratumor heterogeneity (RNA-ITH) that limits the reproducibility of expression-based prognostic
Externí odkaz:
https://doaj.org/article/b6fe0a65261748579d8ae587987a1d01
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract The tumor microenvironment (TME) plays a fundamental role in tumorigenesis, tumor progression, and anti-cancer immunity potential of emerging cancer therapeutics. Understanding inter-patient TME heterogeneity, however, remains a challenge to
Externí odkaz:
https://doaj.org/article/38900c22a8a24e709b0c4f0b13cb9893
Autor:
Daowei Yang, Xinlei Sun, Rohan Moniruzzaman, Hua Wang, Citu Citu, Zhongming Zhao, Ignacio I. Wistuba, Huamin Wang, Anirban Maitra, Yang Chen
Publikováno v:
Cell Reports Medicine, Vol 5, Iss 9, Pp 101711- (2024)
Summary: Pancreatic cancer is associated with an oncogenic KRAS mutation in approximately 90% of cases. However, a non-negligible proportion of pancreatic cancer cases harbor wild-type KRAS (KRAS-WT). This study establishes genetically engineered mou
Externí odkaz:
https://doaj.org/article/86f14644049346438d351b6697eb089c
Autor:
Mabel Perez-Oquendo, Gabriele Romano, David P. Farris, Varsha Gandhi, Ignacio I. Wistuba, Robert E. Tillman, Ryan Udan, Paolo Mangahas, Rama Soundararajan
Publikováno v:
BMC Medical Education, Vol 24, Iss 1, Pp 1-12 (2024)
Abstract The United States government makes a substantial investment in biomedical training programs each year. However, for most trainees, these opportunities do not translate into career progression in academic research pathways. Only about one-fif
Externí odkaz:
https://doaj.org/article/5cff586dbc0344188e10aa42c9cb42e6
Autor:
Sheeba J. Sujit, Muhammad Aminu, Tatiana V. Karpinets, Pingjun Chen, Maliazurina B. Saad, Morteza Salehjahromi, John D. Boom, Mohamed Qayati, James M. George, Haley Allen, Mara B. Antonoff, Lingzhi Hong, Xin Hu, Simon Heeke, Hai T. Tran, Xiuning Le, Yasir Y. Elamin, Mehmet Altan, Natalie I. Vokes, Ajay Sheshadri, Julie Lin, Jianhua Zhang, Yang Lu, Carmen Behrens, Myrna C. B. Godoy, Carol C. Wu, Joe Y. Chang, Caroline Chung, David A. Jaffray, Ignacio I. Wistuba, J. Jack Lee, Ara A. Vaporciyan, Don L. Gibbons, John Heymach, Jianjun Zhang, Tina Cascone, Jia Wu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract While we recognize the prognostic importance of clinicopathological measures and circulating tumor DNA (ctDNA), the independent contribution of quantitative image markers to prognosis in non-small cell lung cancer (NSCLC) remains underexplor
Externí odkaz:
https://doaj.org/article/8ee2d864530b4ff5bcd6763fb81cd4af
Autor:
Jose A. Karam, Pavlos Msaouel, Cara L. Haymaker, Surena F. Matin, Matthew T. Campbell, Amado J. Zurita, Amishi Y. Shah, Ignacio I. Wistuba, Enrica Marmonti, Dzifa Y. Duose, Edwin R. Parra, Luisa Maren Solis Soto, Caddie Laberiano-Fernandez, Marisa Lozano, Alice Abraham, Max Hallin, Curtis D. Chin, Peter Olson, Hirak Der-Torossian, Xiaohong Yan, Nizar M. Tannir, Christopher G. Wood
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Sitravatinib is an immunomodulatory tyrosine kinase inhibitor that can augment responses when combined with programmed death-1 inhibitors such as nivolumab. We report a single-arm, interventional, phase 2 study of neoadjuvant sitravatinib in
Externí odkaz:
https://doaj.org/article/8affada371c5430f97f977800c38a734
Autor:
Raphael E. Steiner, Edwin R. Parra, Francisco Vega, Lei Feng, Jason R. Westin, Sattva S. Neelapu, Paolo Strati, Michael R. Green, Christopher R. Flowers, Luisa M. Solis, Ignacio I. Wistuba, Sairah Ahmed, Ranjit Nair, Fredrick B. Hagemeister, Mansoor Noorani, Mario L. Marques-Piubelli
Publikováno v:
Experimental Hematology & Oncology, Vol 12, Iss 1, Pp 1-5 (2023)
Abstract Primary mediastinal (thymic) large B-cell lymphoma (PMBCL) is a rare, aggressive subtype of non-Hodgkin lymphoma and has a complex inflammatory microenvironment. Although most patients can be cured with standard-of-care immunochemotherapy, p
Externí odkaz:
https://doaj.org/article/e3114eba62f94495bc871889c61eb0f9
Autor:
Jessica M. Konen, B. Leticia Rodriguez, Haoyi Wu, Jared J. Fradette, Laura Gibson, Lixia Diao, Jing Wang, Stephanie Schmidt, Ignacio I. Wistuba, Jianjun Zhang, Don L. Gibbons
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 17 (2023)
Non–small cell lung cancers that harbor concurrent KRAS and TP53 (KP) mutations are immunologically warm tumors with partial responsiveness to anti–PD-(L)1 blockade; however, most patients observe little or no durable clinical benefit. To identif
Externí odkaz:
https://doaj.org/article/c91ebec70cb74fa7b67c8100444ae89e
Autor:
Uyen Q. Le, Nanyue Chen, Seetharaman Balasenthil, Eugene Lurie, Fei Yang, Suyu Liu, Laura Rubin, Luisa Maren Solis Soto, Maria Gabriela Raso, Harsh Batra, Aysegul A. Sahin, Ignacio I. Wistuba, Ann McNeill Killary
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Triple negative breast cancer (TNBC) is a disease of poor prognosis, with the majority classified as the basal-like subtype associated with epithelial-mesenchymal transition and metastasis. Because basal breast cancers originate from prolife
Externí odkaz:
https://doaj.org/article/b9e81eddcc574b83a9261ff9ed2b1014
Autor:
Mario L. Marques-Piubelli, Jesus Navarrete, Debora A. Ledesma, Courtney W. Hudgens, Rossana N. Lazcano, Ali Alani, Auris Huen, Madeleine Duvic, Priyadharsini Nagarajan, Phyu P. Aung, Ignacio I. Wistuba, Jonathan L. Curry, Roberto N. Miranda, Carlos A. Torres-Cabala
Publikováno v:
Cells, Vol 13, Iss 5, p 419 (2024)
Granulomatous Mycosis Fungoides (GMF) is a rare form of mycosis fungoides (MF) characterized by a granulomatous infiltrate associated with the neoplastic lymphoid population and is considered to have a worse prognosis compared with regular MF. The up
Externí odkaz:
https://doaj.org/article/d32a078379274fe698707b1ef99c729c