Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Ignacio Hugo Castro"'
Autor:
Luciana Capece, María Florencia Pignataro, Liliana Dain, Ignacio Hugo Castro, Lucía D. Espeche, Javier Santos, Karl Ellioth Sewell
Publikováno v:
Archives of biochemistry and biophysics. 715
In humans, the loss of frataxin results in Friedreich's Ataxia, a neurodegenerative disease, in which a deficit in the iron-sulfur cluster assembly is observed. In this work, we analyzed three frataxin variants in which one tryptophan was replaced by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edaa373c497171a4333b85766db68400
https://pubmed.ncbi.nlm.nih.gov/34801473
https://pubmed.ncbi.nlm.nih.gov/34801473
Autor:
Ignacio Hugo, Castro, María Florencia, Pignataro, Karl Ellioth, Sewell, Lucía Daniela, Espeche, María Georgina, Herrera, Martín Ezequiel, Noguera, Liliana, Dain, Alejandro Daniel, Nadra, Martín, Aran, Clara, Smal, Mariana, Gallo, Javier, Santos
Publikováno v:
Sub-cellular biochemistry. 93
Mammalian frataxin is a small mitochondrial protein involved in iron sulfur cluster assembly. Frataxin deficiency causes the neurodegenerative disease Friedreich's Ataxia. Valuable knowledge has been gained on the structural dynamics of frataxin, met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::85301345e3a126ac5360febbfe5a2f72
https://pubmed.ncbi.nlm.nih.gov/31939159
https://pubmed.ncbi.nlm.nih.gov/31939159
Autor:
Lorenzo Maso, Monica Benini, Alessandra Rufini, Paola Costantini, Roberto Testi, Maria Georgina Herrera, Martín Ezequiel Noguera, Javier Santos, Ignacio Hugo Castro, Alejandro Ferrari
Publikováno v:
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
FEBS Open Bio
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
FEBS Open Bio
Friedreich's ataxia is a disease caused by a decrease in the levels of expression or loss of functionality of the mitochondrial protein frataxin (FXN). The development of an active and stable recombinant variant of FXN is important for protein replac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6ac027bdbfecbcf10a85bd791ba50ad
https://doi.org/10.1002/2211-5463.12376
https://doi.org/10.1002/2211-5463.12376
Autor:
Ignacio Hugo Castro, Davide Doni, Luciana Capece, Martín Ezequiel Noguera, Mauro Bringas, Martin Aran, Javier Santos, Paola Costantini, Matías Blaustein
Publikováno v:
Archives of Biochemistry and Biophysics. 691:108491
The relationships between conformational dynamics, stability and protein function are not obvious. Frataxin (FXN) is an essential protein that forms part of a supercomplex dedicated to the iron-sulfur (Fe–S) cluster assembly within the mitochondria
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38b33cb7f21aa8b4695cad3c0b5f9dd8
https://doi.org/10.1016/j.abb.2020.108491
https://doi.org/10.1016/j.abb.2020.108491