Zobrazeno 1 - 10
of 198
pro vyhledávání: '"Ignacio Gil‐Bazo"'
Autor:
Ander Puyalto, María Rodríguez-Remírez, Inés López, Irati Macaya, Elizabeth Guruceaga, María Olmedo, Anna Vilalta-Lacarra, Connor Welch, Sergio Sandiego, Silvestre Vicent, Karmele Valencia, Alfonso Calvo, Ruben Pio, Luis E. Raez, Christian Rolfo, Daniel Ajona, Ignacio Gil-Bazo
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-19 (2024)
Abstract Background The identification of novel therapeutic strategies to overcome resistance to the MEK inhibitor trametinib in mutant KRAS lung adenocarcinoma (LUAD) is a challenge. This study analyzes the effects of trametinib on Id1 protein, a ke
Externí odkaz:
https://doaj.org/article/a7f566efdb754d68bd28062af5ab4148
Autor:
Irati Macaya, Marta Roman, Connor Welch, Rodrigo Entrialgo-Cadierno, Marina Salmon, Alba Santos, Iker Feliu, Joanna Kovalski, Ines Lopez, Maria Rodriguez-Remirez, Sara Palomino-Echeverria, Shane M. Lonfgren, Macarena Ferrero, Silvia Calabuig, Iziar A. Ludwig, David Lara-Astiaso, Eloisa Jantus-Lewintre, Elizabeth Guruceaga, Shruthi Narayanan, Mariano Ponz-Sarvise, Antonio Pineda-Lucena, Fernando Lecanda, Davide Ruggero, Purvesh Khatri, Enrique Santamaria, Joaquin Fernandez-Irigoyen, Irene Ferrer, Luis Paz-Ares, Matthias Drosten, Mariano Barbacid, Ignacio Gil-Bazo, Silve Vicent
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Drug combinations are key to circumvent resistance mechanisms compromising response to single anti-cancer targeted therapies. The implementation of combinatorial approaches involving MEK1/2 or KRASG12C inhibitors in the context of KRAS-mutat
Externí odkaz:
https://doaj.org/article/e4df0207a07b4df791d9fb4bec0b4c62
Autor:
Benito Farina, Ana Delia Ramos Guerra, David Bermejo-Peláez, Carmelo Palacios Miras, Andrés Alcazar Peral, Guillermo Gallardo Madueño, Jesús Corral Jaime, Anna Vilalta-Lacarra, Jaime Rubio Pérez, Arrate Muñoz-Barrutia, German R. Peces-Barba, Luis Seijo Maceiras, Ignacio Gil-Bazo, Manuel Dómine Gómez, María J. Ledesma-Carbayo
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-15 (2023)
Abstract Background Identifying predictive non-invasive biomarkers of immunotherapy response is crucial to avoid premature treatment interruptions or ineffective prolongation. Our aim was to develop a non-invasive biomarker for predicting immunothera
Externí odkaz:
https://doaj.org/article/399bc1686fc84f0fbfd92c6c8452620b
Autor:
Ander Puyalto, María Rodríguez-Remírez, Inés López, Fabiola Iribarren, Jon Ander Simón, Marga Ecay, María Collantes, Anna Vilalta-Lacarra, Alejandro Francisco-Cruz, Jose Luis Solórzano, Sergio Sandiego, Iván Peñuelas, Alfonso Calvo, Daniel Ajona, Ignacio Gil-Bazo
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundHarnessing the anti-tumor immune system response by targeting the program cell death protein (PD-1) and program cell death ligand protein (PD-L1) axis has been a major breakthrough in non-small cell lung cancer (NSCLC) therapy. Nonetheless,
Externí odkaz:
https://doaj.org/article/6925a7c87bd849e1b214135adddcbb6a
Autor:
Christian Caglevic, Christian Rolfo, Ignacio Gil-Bazo, Andrés Cardona, Jorge Sapunar, Fred R. Hirsch, David R. Gandara, Gilberto Morgan, Silvia Novello, Marina-Chiara Garassino, Giannis Mountzios, Natasha B. Leighl, Denisse Bretel, Oscar Arrieta, Alfredo Addeo, Stephen V. Liu, Luis Corrales, Vivek Subbiah, Francisco Aboitiz, Franz Villarroel-Espindola, Felipe Reyes-Cosmelli, Ricardo Morales, Mauricio Mahave, Luis Raez, Jorge Alatorre, Edgardo Santos, Luis Ubillos, Daniel S.W. Tan, Christoph Zielinski
Publikováno v:
JCO Global Oncology, Vol , Iss 8 (2022)
On February 24, 2022, a war began within the Ukrainian borders. At least 3.0 million Ukrainian inhabitants have already fled the country. Critical infrastructure, including hospitals, has been damaged. Children with cancer were urgently transported t
Externí odkaz:
https://doaj.org/article/169c0613581d4a2aac6760d22c60d06f
Autor:
Juan Pablo Fusco, Guillermo Pita, María José Pajares, Maria Pilar Andueza, Ana Patiño‐García, Juan P. de‐Torres, Alfonso Gurpide, Javier Zulueta, Rosario Alonso, Nuria Alvarez, Ruben Pio, Ignacio Melero, Miguel F. Sanmamed, Maria Rodriguez Ruiz, Ignacio Gil‐Bazo, Jose María Lopez‐Picazo, Ciro Casanova, Rebeca Baz Davila, Antonio Agudo, Maria Dolores Lozano, Alvaro Gonzalez, Nuria Sala, Eva Ardanaz, Javier Benitez, Luis Montuenga, Anna Gonzalez‐Neira, Jose Luis Perez‐Gracia
Publikováno v:
Cancer Medicine, Vol 7, Iss 7, Pp 3474-3483 (2018)
Abstract Single nucleotide polymorphisms (SNPs) may modulate individual susceptibility to carcinogens. We designed a genome‐wide association study to characterize individuals presenting extreme phenotypes of high and low risk to develop tobacco‐i
Externí odkaz:
https://doaj.org/article/c3b285810a764be5ae798d81e210d99b
KRAS oncogene in non-small cell lung cancer: clinical perspectives on the treatment of an old target
Autor:
Marta Román, Iosune Baraibar, Inés López, Ernest Nadal, Christian Rolfo, Silvestre Vicent, Ignacio Gil-Bazo
Publikováno v:
Molecular Cancer, Vol 17, Iss 1, Pp 1-14 (2018)
Abstract Lung neoplasms are the leading cause of death by cancer worldwide. Non-small cell lung cancer (NSCLC) constitutes more than 80% of all lung malignancies and the majority of patients present advanced disease at onset. However, in the last dec
Externí odkaz:
https://doaj.org/article/28f1f689a55440d1ac11f87759a2cbf8
Autor:
Simona Taverna, Marzia Pucci, Marco Giallombardo, Maria Antonietta Di Bella, Mariacarmela Santarpia, Pablo Reclusa, Ignacio Gil-Bazo, Christian Rolfo, Riccardo Alessandro
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract Non-small cell lung cancer (NSCLC) remains the leading cause of cancer-related deaths worldwide. The majority of patients are diagnosed in advanced disease stage. Bone metastasis is the most frequent complication in NSCLC resulting in osteol
Externí odkaz:
https://doaj.org/article/db6a33130d004cc092b9ee22df28e4be
Autor:
Rocío Figueroa, Ana Alfonso, María Marcos, José María López-Picazo, Alberto García-Mouriz, Ignacio Gil-Bazo, José Rifón, José Hermida, José Antonio Páramo, Ramón Lecumberri
Publikováno v:
TH Open, Vol 03, Iss 02, Pp e153-e156 (2019)
Externí odkaz:
https://doaj.org/article/ec7d2ce31c4e401fa94c58550479e403
Autor:
Rocío Figueroa, Ana Alfonso, José López-Picazo, Ignacio Gil-Bazo, Alberto García-Mouriz, José Hermida, José Antonio Páramo, Ramón Lecumberri
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0200220 (2018)
Hospitalized cancer patients are at high risk of venous thromboembolism (VTE). Despite current recommendations in clinical guidelines, thromboprophylaxis with low molecular weight heparin (LMWH) is underused. We performed an observational prospective
Externí odkaz:
https://doaj.org/article/89af5410784c426c9c9a067d7b892b74