Mechanisms of robustness in gene regulatory networks involved in neural development

Autor: Camila D. Arcuschin, Marina Pinkasz, Ignacio E. Schor

Publikováno v: Frontiers in Molecular Neuroscience, Vol 16 (2023)

The functions of living organisms are affected by different kinds of perturbation, both internal and external, which in many cases have functional effects and phenotypic impact. The effects of these perturbations become particularly relevant for mult

Externí odkaz: https://doaj.org/article/9a6e523255b44e28858b4bec41a6194e

Playing inside the genes Intragenic histone acetylation after membrane depolarization of neural cells opens a path for alternative splicing regulation

Autor: Ignacio E. Schor, Alberto R. Kornblihtt

Publikováno v: Communicative & Integrative Biology, Vol 2, Iss 4, Pp 341-343 (2009)

Regulation of alternative splicing is coupled to transcription quality, the polymerase elongation rate being an important factor in modulating splicing choices. In a recently published work, we provide evidence that intragenic histone acetylation pat

Externí odkaz: https://doaj.org/article/e7cd507211704e1e9cb498acc9a70913

A DNA intercalating dye-based RT-qPCR alternative to diagnose SARS-CoV-2

Autor: Juan C. Muñoz, Gonzalo Cabrerizo, Marcos Palavecino, Manuel J. Muñoz, José N. Stigliano, Nicolás Nieto Moreno, Anabella Srebrow, Ignacio E Schor, Fabian Rudolf, Micaela A. Godoy Herz, Martín Avaro, Cybele C. García, Elsa Baumeister, Valeria Buggiano, Lucas Servi, Estefanía Benedetti, Federico Remes Lenicov, Alberto R. Kornblihtt, Laureano Bragado, Ezequiel Petrillo, Federico Fuchs Wightman, Andrea Pontoriero, José Clemente, Manuel de la Mata

Publikováno v: RNA Biology
article-version (VoR) Version of Record
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Early detection of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been proven crucial during the efforts to mitigate the effects of the COVID-19 pandemic. Several diagnostic methods have emerged in the past few months, each with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4ea169b5cfaedc2c38ee34ada322aa6
https://doi.org/10.1080/15476286.2021.1926648

Accurate genome-wide predictions of spatio-temporal gene expression during embryonic development

Autor: Alicja Tadych, Raquel Marco-Ferreres, Ignacio E. Schor, Jian Zhou, Victoria Yao, Eileen E. M. Furlong, Chandra L. Theesfeld, Olga G. Troyanskaya

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
PLoS Genetics
PLoS Genetics, Vol 15, Iss 9, p e1008382 (2019)

Comprehensive information on the timing and location of gene expression is fundamental to our understanding of embryonic development and tissue formation. While high-throughput in situ hybridization projects provide invaluable information about devel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e7753ba7e885fe32fa375a0e0b0ede5
https://dx.plos.org/10.1371/journal.pgen.1008382

Sustained CaMKII Delta Gene Expression Is Specifically Required for Long-Lasting Memories in Mice

Autor: Noel Federman, Ana Fiszbein, Verónica de la Fuente, Arturo Romano, Ignacio E Schor, Leila Ameneiro, Gisela Zalcman

Publikováno v: Molecular neurobiology. 56(2)

Although important information is available on the molecular mechanisms of long-term memory formation, little is known about the processes underlying memory persistence in the brain. Here, we report that persistent gene expression of CaMKIIδ isoform

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aea6e511884fd1fd8dd06ff0116a393d
https://pubmed.ncbi.nlm.nih.gov/29948945