Chlorinated Guaiane-Type Sesquiterpene Lactones as Cytotoxic Agents against Human Tumor Cells

Autor: Francisco Estévez-Sarmiento, Ester Saavedra, Mercedes Ruiz-Estévez, Francisco León, José Quintana, Ignacio Brouard, Francisco Estévez

Publikováno v: International Journal of Molecular Sciences, Vol 21, Iss 24, p 9767 (2020)

Guaiane-type sesquiterpene lactones are naturally occurring compounds which have attracted attention due to their array of biological activities. In this study, chlorinated guaianolides 1–8, isolated from plants of the genus Centaurea, were evaluat

Externí odkaz: https://doaj.org/article/d99520e58e604aff93b1e7db8baad170

Secondary Metabolites from Two Species of Tolpis and Their Biological Activities

Autor: Francisco León, Ignacio Brouard, Francisco Estévez, María Teresa Marrero, Aroa López, Milagros Rico, Francisco Javier Pérez, Mariana López, Jorge Triana

Publikováno v: Molecules, Vol 17, Iss 11, Pp 12895-12909 (2012)

Phytochemical research of two Tolpis species, T. proustii and T. lagopoda, led to the isolation of three new compounds: 30-chloro-3β-acetoxy-22α-hydroxyl-20(21)-taraxastene (1), 3β,22α-diacetoxy-30-ethoxy-20(21)-taraxastene (2) and 3β,28-dihydro

Externí odkaz: https://doaj.org/article/0f2e27fc0f884732bcc95fd6bfdbf2bb

Coumarins and other constituents from Deverra battandieri

Autor: Chahrazed Esseid, Paul Mosset, Francisco León, Samir Benayache, Fadila Benayache, Ignacio Brouard, Eric Marchioni

Publikováno v: Phytochemistry Letters
Phytochemistry Letters, Elsevier, 2021, 42, pp.129-133. ⟨10.1016/j.phytol.2020.08.013⟩
Digital.CSIC. Repositorio Institucional del CSIC
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Phytochemistry Letters, 2021, 42, pp.129-133. ⟨10.1016/j.phytol.2020.08.013⟩

Three undescribed coumarin derivatives, pituranthosin A–C (1-3), along with nineteen known compounds were isolated and identified from the chloroform and ethyl acetate fractions of the hydroalcoholic extract of Deverra battandieri (Apiaceae). The s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::342a3429b5d158a71f2c5923b7bee5c5
https://hal.archives-ouvertes.fr/hal-03122729

The synthetic flavanone 6-methoxy-2-(naphthalen-1-yl)chroman-4-one induces apoptosis and activation of the MAPK pathway in human U-937 leukaemia cells

Autor: Francisco Estévez, Celina García, Ignacio Brouard, Henoc del Rosario, Ester Saavedra, Judith Hernandez-Garces, José Quintana

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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Synthetic flavonoids containing a naphthalene ring have attracted attention as potential cytotoxic compounds. Here, we synthesized ten chalcones and their corresponding flavanones and evaluated their antiproliferative activity against the human tumou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::170ae01727bb16b21755e8317e375cb3
http://hdl.handle.net/10261/209122

Centaurea microcarpa Coss. & Dur. (Asteraceae) extracts: New cyanogenic glucoside and other constituents

Autor: Ratiba Mekkiou, Thamere Cheriet, Samia Baatouche, Ignacio Brouard, Francisco León, Ramdane Seghiri, O. Boumaza, Samir Benayache, Fadila Benayache, Djamel Sarri

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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The phytochemical investigation of both chloroform and ethyl acetate extracts of Centaurea microcarpa Coss. & Dur. led to the isolation of a new cyanogenic glucoside 6'-methacrylate prunasin (3) together with seven known compounds: hydroxy-11β,13-di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::922474a2653b50421363dc8dde8cb8d2
https://doi.org/10.1080/14786419.2018.1517343