In Silico and In Vitro Evaluation of Bevacizumab Biosimilar MB02 as an Antitumor Agent in Canine Mammary Carcinoma

Autor: Georgina A. Cardama, Paula L. Bucci, Jesús S. Lemos, Candela Llavona, Micaela A. Benavente, Eva Hellmén, María Laura Fara, Eduardo Medrano, Eduardo Spitzer, Ignacio A. Demarco, Patricia Sabella, Juan Garona, Daniel F. Alonso

Publikováno v: Animals, Vol 13, Iss 15, p 2507 (2023)

Canine mammary carcinomas (CMC) are associated with major aggressive clinical behavior and high mortality. The current standard of care is based on surgical resection, without an established effective treatment scheme, highlighting the urgent need to

Externí odkaz: https://doaj.org/article/9e0424f45d844cd3943bd3a9a65bc0bd

Computer-assisted image analysis protocol that quantitatively measures subnuclear protein organization in cell populations

Autor: Ty C. Voss, Ignacio A. Demarco, Cynthia F. Booker, Richard N. Day

Publikováno v: BioTechniques, Vol 36, Iss 2, Pp 240-247 (2004)

Many nuclear proteins, including the nuclear receptor co-repressor (NCoR) protein are localized to specific regions of the cell nucleus, and this subnuclear positioning is preserved when NCoR is expressed in cells as a fusion to a fluorescent protein

Externí odkaz: https://doaj.org/article/5dc7783140be47fba192822ee5ff46dd

Antibody-dependent cell-mediated cytotoxicity induced by active immunotherapy based on racotumomab in non-small cell lung cancer patients

Autor: Marcelo D. Guthmann, Daniel F. Alonso, Ignacio A. Demarco, Marina Albertó, Mariano Rolando Gabri, Cynthia A. Gulino, Cecilia Venier, Héctor Adrián Cuello, Valeria Inés Segatori

Publikováno v: Cancer Immunology, Immunotherapy. 67:1285-1296

Antitumor strategies based on positive modulation of the immune system currently represent therapeutic options with prominent acceptance for cancer patients’ treatment due to its selectivity and higher tolerance compared to chemotherapy. Racotumoma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a08b655e9fc5ba54af8ae7a387b288a
https://doi.org/10.1007/s00262-018-2188-y

A phase II dose‑escalation trial of perioperative desmopressin (1‑desamino‑8‑D‑arginine vasopressin) in breast cancer patients

Autor: Daniel F. Alonso, Ignacio A. Demarco, Ricardo Sánchez-Marull, Ana Vanesa Torbidoni, Marcelo O Grecco, Roberto Gómez, Francisco J Terrier, Esteban Maronna, Gimena S Ferro, Isabel Frahm, Nancy V Perroni, Graciela N Ciccia, Marcelo D. Guthmann, Eduardo Spitzer, Juan Garona, Daniel E. Gomez, Marina Pifano, Ruth S Weinberg, Daniela Di Leo, Giselle V. Ripoll, Analía Sánchez-Luceros, Debora J Seigelshifer

Publikováno v: SEDICI (UNLP)
Universidad Nacional de La Plata
instacron:UNLP
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
SpringerPlus

Desmopressin (dDAVP) is a well-known peptide analog of the antidiuretic hormone vasopressin, used to prevent excessive bleeding during surgical procedures. dDAVP increases hemostatic mediators, such as the von Willebrand factor (vWF), recently consid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c67c7ec633c7edac9cd82790a5481c5
https://springerplus.springeropen.com/articles/10.1186/s40064-015-1217-y

Corepressor subnuclear organization is regulated by estrogen receptor via a mechanism that requires the DNA-binding domain

Autor: Richard O. Day, Cynthia F. Booker, Ignacio A. Demarco, Ty C. Voss

Publikováno v: Molecular and Cellular Endocrinology. 231:33-47

The restriction of transcription factors to certain domains within the cell nucleus must serve an important regulatory function. The silencing mediator of retinoic acid and thyroid hormone (SMRT) and other members of the corepressor complex are enric

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2cdaa08d12a678f1c04cb229ccb5fcf
https://doi.org/10.1016/j.mce.2004.12.003