IVIG regulates the survival of human but not mouse neutrophils

Autor: Jan D. Lünemann, Iglika K Djoumerska-Alexieva, Stephan M. Jakob, Hans-Uwe Simon, Christoph Schneider, Petya Dimitrova, Stephan von Gunten, Christian W. Keller, Fabian Käsermann, Stefanie Graeter, Donald R. Branch, Tankica Maneva Timcheva, Isaak Quast, Simone Wicki, Danila Leontyev, Richard D. Cummings, Thomas Kaufmann

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Scientific Reports
Schneider, Christoph; Wicki, Simone; Graeter, Stefanie; Maneva Timcheva, Tankica; Keller, Christian W; Quast, Isaak; Leontyev, Danila; Djoumerska-Alexieva, Iglika K; Käsermann, Fabian; Jakob, Stephan; Dimitrova, Petya A; Branch, Donald R; Cummings, Richard D; Lünemann, Jan D; Kaufmann, Thomas; Simon, Hans-Uwe; von Gunten, Stephan (2017). IVIG regulates the survival of human but not mouse neutrophils. Scientific Reports, 7(1), p. 1296. Nature Publishing Group 10.1038/s41598-017-01404-0

Intravenous immunoglobulin (IVIG) are purified IgG preparations made from the pooled plasma from thousands of healthy donors and are being tested in preclinical mouse models. Inherent challenges, however, are the pluripotency of IVIG and its xenogene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8d52d3d33f3c6e9ca7b9068ce6eefd8
https://doi.org/10.1038/s41598-017-01404-0

The protective effect of modified intravenous immunoglobulin in LPS sepsis model is associated with an increased IRA B cells response

Autor: Shina Pashova, Anastas Pashov, Iglika K Djoumerska-Alexieva, Tchavdar L. Vassilev

Publikováno v: Autoimmunity reviews

Intravenous immunoglobulin preparations (IVIg) that have undergone a mild oxidizing treatment with ferrous ions have an increased polyspecificity, which is not associated with a higher propensity to form aggregates. Among other biological properties

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b704cb85477d9493413e3116e02263f

Exposure of IgG to an acidic environment results in molecular modifications and in enhanced protective activity in sepsis

Autor: Srinivas V. Kaveri, Jordan D. Dimitrov, Sébastien Lacroix-Desmazes, Iglika K Djoumerska-Alexieva, Tchavdar L. Vassilev, Elisaveta Voynova

Publikováno v: FEBS Journal. 277:3039-3050

IgG molecules are exposed on a regular basis to acidic conditions during immunoaffinity purification procedures, as well as during the production of some therapeutic immunoglobulin preparations. This exposure is known to induce in them an antigen-bin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c4ef847106ebf389bd22fef98f17cd8e
https://doi.org/10.1111/j.1742-4658.2010.07714.x

Intravenous Immunoglobulin with Enhanced Polyspecificity Improves Survival in Experimental Sepsis and Aseptic Systemic Inflammatory Response Syndromes

Autor: Iglika K Djoumerska-Alexieva, Srini V. Kaveri, Elisaveta Voynova, Nina Ivanovska, Ralf A. Claus, Catherine Fitting, Tchavdar Vassilev, Jean-Marc Cavaillon, Jordan D. Dimitrov, Clemens L. Bockmeyer, Markus Bläss, Michael Bauer, Zvetanka Stefanova, Petya Dimitrova, Sandro Lindig, Stephan von Gunten, Maya Hadzhieva, Anastas Pashov, Lubka T. Roumenina

Publikováno v: Molecular Medicine
Molecular Medicine, 2015, 21 (1), pp.1002-1010. ⟨10.2119/molmed.2014.00224⟩
Mol Med
Molecular Medicine, Feinstein Institute for Medical Research, 2015, 21 (1), pp.1002-1010. ⟨10.2119/molmed.2014.00224⟩
Molecular Medicine, Feinstein Institute for Medical Research, 2015, 21 (1), pp.1002-1010. 〈10.2119/molmed.2014.00224〉

International audience; Sepsis is a major cause for death worldwide. Numerous interventional trials with agents neutralizing single pro-inflammatory mediators have failed to improve survival in sepsis and aseptic systemic inflammatory response syndro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f96cf9f27bfc71936ad643938ce9a079
https://hal-pasteur.archives-ouvertes.fr/pasteur-01450975/document

Protein destabilizing agents induce polyreactivity and enhanced immunomodulatory activity in IVIg preparations

Autor: Julia Nacheva, Iglika K Djoumerska-Alexieva, Jordan D. Dimitrov, Srini V. Kaveri, Tchavdar L. Vassilev

Publikováno v: Autoimmunity. 42:365-367

Normal pooled human IVIg are produced using various blood protein fractionation technologies and as a result they may well differ in their biological properties. We have demonstrated that exposure of IVIg, for a period as short as 15 min, to protein-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3fe35f1ecf7d4e3fc63573255363a9d3
https://doi.org/10.1080/08916930902832181