What can we do about patients presenting with myeloma and severe renal failure? Observations from the UK MERIT plasma exchange trial

Autor: Judith Behrens, Gill Gaskin, Neil Iggo, Jonathan Barratt, Jane Tighe, Richard Soutar, Gordon Cook, Mary Drake, Curly Morris, Mark Drayson

Publikováno v: eJHaem, Vol 4, Iss 1, Pp 246-250 (2023)

Abstract Myeloma patients presenting with renal failure continue to have a poor prognosis despite significant advances in anti‐myeloma therapy. MERIT was a randomised clinical trial (RCT), set up to evaluate if mechanical reduction of elevated free

Externí odkaz: https://doaj.org/article/b9eb3fe22bd84257b9e2a1c72219f7b4

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A genome-wide association study suggests correlations of common genetic variants with peritoneal solute transfer rates in patients with kidney failure receiving peritoneal dialysis

Autor: Pisoni, Ronald, Robinson, Bruce, Johnson, David, Cho, Yeoungjee, Wong, Muh Geot, Mather, Amanda, Cooper, Bruce, Devuyst, Olivier, Morelle, Johann, Goffin, Eric, Bammens, Bert, Bovy, Philippe, Margetts, Peter, Perl, Jeffrey, Taylor, Paul, Jain, Arsh, Jassal, Vanita, Stenvinkel, Peter, Heimburger, Olof, Kuan, Ying, Harron, Camille, Dasgupta, Indranil, Stoves, John, Akbani, Habib, Abeygunasekara, Sumith, Sharples, Edward, Mead, Paul, Hayat, Amer, Morgan, Neal, Cramp, Hilary, Robertson, Susan, Fielding, Richard, Brown, Edwina, Collinson, Helen, Ande, Pravene, Doulton, Tim, MacDougall, Iain, Cairns, Hugh, Vilar, Enric, Vardhan, Anand, Chess, James, Sandhu, Kanwaljit, Wilkie, Martin, McHaffie, Gavin, Lewis, Robert, Kamesh, Lavanya, Buck, Kate, Peel, Robert, Taylor, Jo, Johnston, Paul, Leung, Janson, Bingham, Coralie, Anijeet, Hameed, Asghar, Ramzana, Ranakrishna, Satish, Nair, Sunita, Iggo, Neil, Lewis, David, Udayaraj, Uday, Dawson, Susan, Woordrow, Graham, Chandrasekar, Thangavelu, Hamer, Rizwan, Barratt, Jonathan, Baines, Richard, Davies, Simon, Donovan, Kieron, Jones, Colin, Ynares, Christina, Dukes, Carl, Imam, Talha H., Corapi, Kristin, Nigwekar, Sagar, Khawar, Osman, Weiner, Daniel, Lau, Wei Ling, Harley, Kevin, Ghaffari, Arshia, Saxena, Ramesh, Abraham, Josephine, Mehrotra, Rajnish, Himmelfarb, Jonathan, Cavanaugh, Kerri L., Golper, Thomas A., Burkart, John M., Pirkle, James L., Miller, Brent, Jang, Judy, Turner, Jeffrey, Stanaway, Ian B., Jarvik, Gail P., Lambie, Mark, Johnson, David W., Davies, Simon J.

Publikováno v: In Kidney International May 2021

Solid-type adenoid cystic carcinoma of the breast, a distinct molecular entity enriched in NOTCH and CREBBP mutations

Autor: Massé, Julie, Truntzer, Caroline, Boidot, Romain, Khalifa, Emmanuel, Pérot, Gaëlle, Velasco, Valérie, Mayeur, Laétitia, Billerey-Larmonier, Claire, Blanchard, Larry, Charitansky, Hélène, Soubeyran, Isabelle, Iggo, Richard, Arnould, Laurent, MacGrogan, Gaëtan

Publikováno v: In Modern Pathology June 2020 33(6):1041-1055

A genome‐scale CRISPR knock‐out screen in chronic myeloid leukemia identifies novel drug resistance mechanisms along with intrinsic apoptosis and MAPK signaling

Autor: Matthieu Lewis, Valérie Prouzet‐Mauléon, Florence Lichou, Elodie Richard, Richard Iggo, Béatrice Turcq, François‐Xavier Mahon

Publikováno v: Cancer Medicine, Vol 9, Iss 18, Pp 6739-6751 (2020)

Abstract Understanding resistance mechanisms in cancer is of utmost importance for the discovery of novel “druggable” targets. Efficient genetic screening, now even more possible with CRISPR‐Cas9 gene‐editing technology, next‐generation seq

Externí odkaz: https://doaj.org/article/ee2e1b61d9ac4c1882f8c1d944da62fe