Zobrazeno 1 - 10
of 2 583
pro vyhledávání: '"IgG1"'
Autor:
Dafei Chai, Junhao Wang, Chunmei Fan, Jing-Ming Lim, Xu Wang, Praveen Neeli, Xinfang Yu, Ken H. Young, Yong Li
Publikováno v:
Journal of Hematology & Oncology, Vol 17, Iss 1, Pp 1-23 (2024)
Abstract Background p53, the most frequently mutated gene in cancer, lacks effective targeted drugs. Methods We developed monoclonal antibodies (mAbs) that target a p53 hotspot mutation E285K without cross-reactivity with wild-type p53. They were del
Externí odkaz:
https://doaj.org/article/c893d2f686c94ed580b6f8dd6e662166
Autor:
Soham Sengupta, Malini Sen
Publikováno v:
mSphere, Vol 9, Iss 9 (2024)
ABSTRACT We investigated the influence of a Wnt5A–gut microbiota axis on gut B-cell repertoire and protection from infection, having previously demonstrated that Wnt5A in association with gut commensals helps shape gut T-cell repertoire. Accordingl
Externí odkaz:
https://doaj.org/article/aaf413fe67a54832b67b907ad29616c5
Publikováno v:
mAbs, Vol 16, Iss 1 (2024)
Development of novel therapeutic proteins and biosimilars requires a thorough understanding of the relationship between their structure and function. Particularly, how IgG glycosylation affects its effector functions is a point increasingly underscor
Externí odkaz:
https://doaj.org/article/6c057d7513b44d1cb450e73700405754
Autor:
Fatemeh Hajari Taheri, Mahmoud Hassani, Zahra Sharifzadeh, Mahdi Behdani, Shahryar Abdoli, Mahtab Sayadi, Kowsar Bagherzadeh, Arash Arashkia, Mohsen Abolhassani
Publikováno v:
BMC Biotechnology, Vol 24, Iss 1, Pp 1-11 (2024)
Abstract Background The chimeric antigen receptor-expressing T (CAR-T) cells for cancer immunotherapy have obtained considerable clinical importance. CAR T cells need an optimized intracellular signaling domain to get appropriately activated and also
Externí odkaz:
https://doaj.org/article/34c98967d11441c9b51ec26d36bc237f
Autor:
Yujiao Zhang, Bilal Niazi, Auda Auda, Angel Ann Chacko, Amer Jarri, Abdifatah Mohamed, Saad Ali, Hongfa Zhu, Syed Sirajuddin
Publikováno v:
Case Reports in Gastroenterology, Vol 17, Iss 1, Pp 281-286 (2023)
Autoimmune hepatitis (AIH) is a common and debilitating pathology that has acute, subacute, and chronic presentation, requiring prompt diagnosis and early intervention. Several serologic markers are found to be associated with the pathogenesis and pr
Externí odkaz:
https://doaj.org/article/3a0d62205759403498f122398f712417
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)
Murine research has revealed a significant role for antibody responses in protection against Chlamydia reinfection. To explore potential humoral immune markers of protection elicited by Chlamydia trachomatis (CT) antigens in humans in the context of
Externí odkaz:
https://doaj.org/article/28ed3099c4764ef586c5b417fb16a2bf
Autor:
A.V. Serritella, N.K.S. Grewal, B. Peterson, K. Arndt, D.D. Gaudio, P. Liu, A. Shergill, B. Polite, H.L. Kindler, D.V.T. Catenacci, C.Y. Liao
Publikováno v:
ESMO Gastrointestinal Oncology, Vol 2, Iss , Pp 100012- (2023)
Background: Immunoglobulin G1 (IgG1) monoclonal antibodies (mAbs), such as trastuzumab and ramucirumab, are utilized in advanced gastroesophageal adenocarcinoma (aGEA). The important mechanism of mAb therapeutic effect is engagement by natural killer
Externí odkaz:
https://doaj.org/article/ce98806709244b9ba25a9270e7def685
Autor:
Andrew B. Waight, David Prihoda, Rojan Shrestha, Kevin Metcalf, Marc Bailly, Marco Ancona, Talal Widatalla, Zachary Rollins, Alan C Cheng, Danny A. Bitton, Laurence Fayadat-Dilman
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTIdentification of favorable biophysical properties for protein therapeutics as part of developability assessment is a crucial part of the preclinical development process. Successful prediction of such properties and bioassay results from calc
Externí odkaz:
https://doaj.org/article/b097c809663e4798a43b8ba6b107fe06
Autor:
Irene Y. Cheung, Audrey Mauguen, Shakeel Modak, Ellen M. Basu, Yi Feng, Brian H. Kushner, Nai Kong Cheung
Publikováno v:
Vaccines, Vol 12, Iss 6, p 587 (2024)
The carbohydrate ganglioside GD2/GD3 cancer vaccine adjuvanted by β-glucan stimulates anti-GD2 IgG1 antibodies that strongly correlate with improved progression-free survival (PFS) and overall survival (OS) among patients with high-risk neuroblastom
Externí odkaz:
https://doaj.org/article/3b4e68713592493d99772656c5f94219
Autor:
Nathalie Bonatti Franco Almeida, Kayla Marie Fantone, Demba Sarr, Nuha Milad Ashtiwi, Sarah Channell, Rafaella Fortini Queiroz Grenfell, Olindo Assis Martins-Filho, Balázs Rada
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionSevere forms of COVID-19, the disease caused by SARS-CoV-2, are characterized by acute respiratory distress syndrome, robust lung inflammation and death in some patients. Strong evidence has been accumulating that polymorphonuclear neutro
Externí odkaz:
https://doaj.org/article/f7c07b329a894db3956e93ab71467775