Age-associated murine cardiac lesions are attenuated by the mitochondria-targeted antioxidant SkQ1

Autor: Vn, Manskikh, Os, Gancharova, Ai, Nikiforova, Ms, Krasilshchikova, Ig, Shabalina, Mv, Egorov, Em, Karger, Ge, Milanovsky, Ii, Galkin, Vp, Skulachev, Roman Zinovkin

Publikováno v: Europe PubMed Central

Age-related changes in mammalian hearts often result in cardiac hypertrophy and fibrosis that are preceded by inflammatory infiltration. In this paper, we show that lifelong treatment of BALB/c and C57BL/6 mice with the mitochondria-targeted antioxid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::36bc63c8316c1b3a0c97173bd369b5eb
http://europepmc.org/abstract/med/25323729

In isolated brown adipose tissue mitochondria, UCP1 is not essential for - nor involved in - the uncoupling effects of the classical uncouplers FCCP and DNP.

Autor: Shabalina IG; Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, SE-106 91, Sweden., Jiménez B; Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, SE-106 91, Sweden., Sousa-Filho CPB; Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, SE-106 91, Sweden., Cannon B; Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, SE-106 91, Sweden. Electronic address: barbara.cannon@su.se., Nedergaard J; Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, SE-106 91, Sweden.

Publikováno v: Biochimica et biophysica acta. Bioenergetics [Biochim Biophys Acta Bioenerg] 2024 Sep 30; Vol. 1866 (1), pp. 149516. Date of Electronic Publication: 2024 Sep 30.

Establishing the potency of N-acyl amino acids versus conventional fatty acids as thermogenic uncouplers in cells and mitochondria from different tissues.

Autor: Gao Y; College of Animal Science and Technology, Northwest A&F University, Yangling, China; The Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden., Shabalina IG; The Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden., Braz GRF; The Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden., Cannon B; The Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden., Yang G; College of Animal Science and Technology, Northwest A&F University, Yangling, China. Electronic address: gsyang999@hotmail.com., Nedergaard J; The Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden. Electronic address: jan.nedergaard@su.se.

Publikováno v: Biochimica et biophysica acta. Bioenergetics [Biochim Biophys Acta Bioenerg] 2022 Apr 01; Vol. 1863 (4), pp. 148542. Date of Electronic Publication: 2022 Feb 19.

Glucocorticoid-Induced Obesity Develops Independently of UCP1.

Autor: Luijten IHN; Department of Molecular Biosciences, the Wenner-Gren Institute, Stockholm University, 106 91 Stockholm, Sweden., Brooks K; Department of Molecular Biosciences, the Wenner-Gren Institute, Stockholm University, 106 91 Stockholm, Sweden., Boulet N; Department of Molecular Biosciences, the Wenner-Gren Institute, Stockholm University, 106 91 Stockholm, Sweden., Shabalina IG; Department of Molecular Biosciences, the Wenner-Gren Institute, Stockholm University, 106 91 Stockholm, Sweden., Jaiprakash A; Department of Molecular Biosciences, the Wenner-Gren Institute, Stockholm University, 106 91 Stockholm, Sweden., Carlsson B; Department of Molecular Biosciences, the Wenner-Gren Institute, Stockholm University, 106 91 Stockholm, Sweden., Fischer AW; Department of Molecular Biosciences, the Wenner-Gren Institute, Stockholm University, 106 91 Stockholm, Sweden; Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg Eppendorf, Hamburg, Germany., Cannon B; Department of Molecular Biosciences, the Wenner-Gren Institute, Stockholm University, 106 91 Stockholm, Sweden., Nedergaard J; Department of Molecular Biosciences, the Wenner-Gren Institute, Stockholm University, 106 91 Stockholm, Sweden. Electronic address: jan@metabol.su.se.

Publikováno v: Cell reports [Cell Rep] 2019 May 07; Vol. 27 (6), pp. 1686-1698.e5.

The GPR120 agonist TUG-891 promotes metabolic health by stimulating mitochondrial respiration in brown fat.

Autor: Schilperoort M; Division of Biomedical Sciences, Warwick Medical School, University of Warwick, Coventry, UK m.schilperoort@lumc.nl m.christian@warwick.ac.uk.; Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden, The Netherlands., van Dam AD; Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden, The Netherlands., Hoeke G; Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden, The Netherlands., Shabalina IG; Department of Molecular Biosciences, The Wenner-Gren Institute, The Arrhenius Laboratories F3, Stockholm University, Stockholm, Sweden., Okolo A; Department of Surgery and Cancer, Institute of Reproductive and Developmental Biology, Imperial College London, London, UK., Hanyaloglu AC; Department of Surgery and Cancer, Institute of Reproductive and Developmental Biology, Imperial College London, London, UK., Dib LH; Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK., Mol IM; Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden, The Netherlands., Caengprasath N; Department of Surgery and Cancer, Institute of Reproductive and Developmental Biology, Imperial College London, London, UK., Chan YW; Lymphocyte Development Group, MRC London Institute of Medical Sciences, Hammersmith Campus Imperial College London, London, UK., Damak S; Nestlé Research Center, Lausanne, Switzerland., Miller AR; Lilly Research Laboratories, Diabetes/Endocrine Department, Lilly Corporate Center, Indianapolis, IN, USA., Coskun T; Lilly Research Laboratories, Diabetes/Endocrine Department, Lilly Corporate Center, Indianapolis, IN, USA., Shimpukade B; Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, Odense, Denmark., Ulven T; Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, Odense, Denmark., Kooijman S; Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden, The Netherlands., Rensen PC; Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden, The Netherlands., Christian M; Division of Biomedical Sciences, Warwick Medical School, University of Warwick, Coventry, UK m.schilperoort@lumc.nl m.christian@warwick.ac.uk.

Publikováno v: EMBO molecular medicine [EMBO Mol Med] 2018 Mar; Vol. 10 (3).