Dapagliflozin, inflammation and left ventricular remodelling in patients with type 2 diabetes and left ventricular hypertrophy

Autor: Adel Dihoum, Alexander JM Brown, Rory J McCrimmon, Chim C Lang, Ify R Mordi

Publikováno v: BMC Cardiovascular Disorders, Vol 24, Iss 1, Pp 1-9 (2024)

Abstract Background and Aims Sodium-glucose co-transporter 2 (SGLT2) inhibitors have beneficial effects in heart failure (HF), including reverse remodelling, but the mechanisms by which these benefits are conferred are unclear. Inflammation is implic

Externí odkaz: https://doaj.org/article/33a82ecb2bdf4a93a0f66ac54313e311

The genomics of heart failure: design and rationale of the HERMES consortium

Autor: R. Thomas Lumbers, Sonia Shah, Honghuang Lin, Tomasz Czuba, Albert Henry, Daniel I. Swerdlow, Anders Mälarstig, Charlotte Andersson, Niek Verweij, Michael V. Holmes, Johan Ärnlöv, Per Svensson, Harry Hemingway, Neneh Sallah, Peter Almgren, Krishna G. Aragam, Geraldine Asselin, Joshua D. Backman, Mary L. Biggs, Heather L. Bloom, Eric Boersma, Jeffrey Brandimarto, Michael R. Brown, Hans‐Peter Brunner‐La Rocca, David J. Carey, Mark D. Chaffin, Daniel I. Chasman, Olympe Chazara, Xing Chen, Xu Chen, Jonathan H. Chung, William Chutkow, John G.F. Cleland, James P. Cook, Simon deDenus, Abbas Dehghan, Graciela E. Delgado, Spiros Denaxas, Alexander S. Doney, Marcus Dörr, Samuel C. Dudley, Gunnar Engström, Tõnu Esko, Ghazaleh Fatemifar, Stephan B. Felix, Chris Finan, Ian Ford, Francoise Fougerousse, René Fouodjio, Mohsen Ghanbari, Sahar Ghasemi, Vilmantas Giedraitis, Franco Giulianini, John S. Gottdiener, Stefan Gross, Daníel F. Guðbjartsson, Hongsheng Gui, Rebecca Gutmann, Christopher M. Haggerty, Pim van derHarst, Åsa K. Hedman, Anna Helgadottir, Hans Hillege, Craig L. Hyde, Jaison Jacob, J. Wouter Jukema, Frederick Kamanu, Isabella Kardys, Maryam Kavousi, Kay‐Tee Khaw, Marcus E. Kleber, Lars Køber, Andrea Koekemoer, Bill Kraus, Karoline Kuchenbaecker, Claudia Langenberg, Lars Lind, Cecilia M. Lindgren, Barry London, Luca A. Lotta, Ruth C. Lovering, Jian'an Luan, Patrik Magnusson, Anubha Mahajan, Douglas Mann, Kenneth B. Margulies, Nicholas A. Marston, Winfried März, John J.V. McMurray, Olle Melander, Giorgio Melloni, Ify R. Mordi, Michael P. Morley, Andrew D. Morris, Andrew P. Morris, Alanna C. Morrison, Michael W. Nagle, Christopher P. Nelson, Christopher Newton‐Cheh, Alexander Niessner, Teemu Niiranen, Christoph Nowak, Michelle L. O'Donoghue, Anjali T. Owens, Colin N.A. Palmer, Guillaume Paré, Markus Perola, Louis‐Philippe Lemieux Perreault, Eliana Portilla‐Fernandez, Bruce M. Psaty, Kenneth M. Rice, Paul M. Ridker, Simon P.R. Romaine, Carolina Roselli, Jerome I. Rotter, Christian T. Ruff, Marc S. Sabatine, Perttu Salo, Veikko Salomaa, Jessica vanSetten, Alaa A. Shalaby, Diane T. Smelser, Nicholas L. Smith, Kari Stefansson, Steen Stender, David J. Stott, Garðar Sveinbjörnsson, Mari‐Liis Tammesoo, Jean‐Claude Tardif, Kent D. Taylor, Maris Teder‐Laving, Alexander Teumer, Guðmundur Thorgeirsson, Unnur Thorsteinsdottir, Christian Torp‐Pedersen, Stella Trompet, Danny Tuckwell, Benoit Tyl, Andre G. Uitterlinden, Felix Vaura, Abirami Veluchamy, Peter M. Visscher, Uwe Völker, Adriaan A. Voors, Xiaosong Wang, Nicholas J. Wareham, Peter E. Weeke, Raul Weiss, Harvey D. White, Kerri L. Wiggins, Heming Xing, Jian Yang, Yifan Yang, Laura M. Yerges‐Armstrong, Bing Yu, Faiez Zannad, Faye Zhao, Regeneron Genetics Center, Jemma B. Wilk, Hilma Holm, Naveed Sattar, Steven A. Lubitz, David E. Lanfear, Svati Shah, Michael E. Dunn, Quinn S. Wells, Folkert W. Asselbergs, Aroon D. Hingorani, Marie‐Pierre Dubé, Nilesh J. Samani, Chim C. Lang, Thomas P. Cappola, Patrick T. Ellinor, Ramachandran S. Vasan, J. Gustav Smith

Publikováno v: ESC Heart Failure, Vol 8, Iss 6, Pp 5531-5541 (2021)

Abstract Aims The HERMES (HEart failure Molecular Epidemiology for Therapeutic targetS) consortium aims to identify the genomic and molecular basis of heart failure. Methods and results The consortium currently includes 51 studies from 11 countries,

Externí odkaz: https://doaj.org/article/77600c13420346d3a1c4c66140b2a3c7

Metformin: evidence from preclinical and clinical studies for potential novel applications in cardiovascular disease

Autor: Adel Dihoum, Graham Rena, Ewan R Pearson, Chim C Lang, Ify R Mordi

Publikováno v: Expert Opinion on Investigational Drugs. 32:291-299

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::18459ce3e664e69c397db140c085641b
https://doi.org/10.1080/13543784.2023.2196010

Biomarker signature and pathophysiological pathways in patients with chronic heart failure and metabolic syndrome

Autor: Camilla C.S. van der Hoef, Eva M. Boorsma, Johanna E. Emmens, Bart J. van Essen, Marco Metra, Leong L. Ng, Stefan D. Anker, Kenneth Dickstein, Ify R. Mordi, Adel Dihoum, Chim C. Lang, Dirk J. van Veldhuisen, Carolyn S.P. Lam, Adriaan A. Voors

Publikováno v: European Journal of Heart Failure. 25:163-173

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::393a3d8dc20b769a29d160d02095859e
https://doi.org/10.1002/ejhf.2760

Plasma Desmosine and Abdominal Aortic Aneurysm Disease

Autor: Ify R. Mordi, Rachael O. Forsythe, Corry Gellatly, Zaid Iskandar, Olivia M. McBride, Athanasios Saratzis, Rod Chalmers, Calvin Chin, Matthew J. Bown, David E. Newby, Chim C. Lang, Jeffrey T. J. Huang, Anna‐Maria Choy

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 8, Iss 20 (2019)

Background It is recognized that factors beyond aortic size are important in predicting outcome in abdominal aortic aneurysm (AAA) disease. AAA is characterized by the breakdown of elastin within the aortic tunica media, leading to aortic dilatation

Externí odkaz: https://doaj.org/article/169adea789704ea68eabcee5009c9c54