Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Iftach Shaked"'
Autor:
Wenqing Li, Virginia Tran, Iftach Shaked, Belinda Xue, Thomas Moore, Rhonda Lightle, David Kleinfeld, Issam A Awad, Mark H Ginsberg
Publikováno v:
eLife, Vol 10 (2021)
Mosaic inactivation of CCM2 in humans causes cerebral cavernous malformations (CCMs) containing adjacent dilated blood-filled multi-cavernous lesions. We used CRISPR-Cas9 mutagenesis to induce mosaic inactivation of zebrafish ccm2 resulting in a nove
Externí odkaz:
https://doaj.org/article/85d99cab3cea493b919621e96939fdf1
Autor:
Iftach Shaked, Conrad Foo, Rui Liu, Yingying Cui, Xiang Ji, Thomas Broggini, Philipp Mächler, Prithu Sundd, Anna Devor, Beth Friedman, David Kleinfeld
How transient hyperglycemia contributes to cerebro-vascular disease has been a challenge to study under controlled conditions. We present an approach to model luminal vessel thrombo-inflammation using amplified, ultrashort laser-pulses to physically
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::535eaf863291307fee11d7598b35c489
https://doi.org/10.1101/2022.08.10.503527
https://doi.org/10.1101/2022.08.10.503527
Author response: Abortive intussusceptive angiogenesis causes multi-cavernous vascular malformations
Autor:
Issam A. Awad, Rhonda Lightle, Iftach Shaked, Mark H. Ginsberg, David Kleinfeld, Virginia Tran, Thomas R. Moore, Belinda Xue, Wenqing Li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::94d3180730124d41be7d92ac45f8470b
https://doi.org/10.7554/elife.62155.sa2
https://doi.org/10.7554/elife.62155.sa2
Publikováno v:
Nature cell biology, vol 23, iss 4
Nature cell biology
Nature Cell Biology, 23(4), 322-329. Nature Publishing Group
Nature cell biology
Nature Cell Biology, 23(4), 322-329. Nature Publishing Group
De novo blood vessel formation occurs through coalescence of endothelial cells (ECs) into a cord-like structure, followed by lumenization either through cell-1-3 or cord-hollowing4-7. Vessels generated in this manner are restricted in diameter to one
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dffc60bf24446e1510f77fc5aca67b13
https://escholarship.org/uc/item/49d9x5fj
https://escholarship.org/uc/item/49d9x5fj
Lumenization ofde novoformed blood vessels occurs either through cell hollowing (intracellular lumen)1–3or cord hollowing (extracellular lumen)4–6and restricts thereby the initial lumen diameter to one or two endothelial cells (ECs) respectively.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::601fdb99a02527a41b7138127d413940
https://doi.org/10.1101/685180
https://doi.org/10.1101/685180
Autor:
Daniel Tracy, Mary Young, Elizabeth T. Golub, Brenda J. Marsh, Christian Gleißner, Robert C. Kaplan, Jason Lazar, Vinayaka R. Prasad, Alan L. Landay, Klaus Ley, Roksana Karim, David B. Hanna, Kathryn Anastos, Mardge H. Cohen, Phyllis C. Tien, Iftach Shaked, Jill Plants
Publikováno v:
Arteriosclerosis, thrombosis, and vascular biology, vol 34, iss 5
Objective— Infection with hepatitis C virus (HCV) or human immunodeficiency virus (HIV) may be associated with atherosclerosis and vascular disease. Macrophages are a major component of atherosclerotic plaque, and classically activated (M1) macroph
Publikováno v:
The Journal of Immunology. 184:4810-4818
In atherosclerotic arteries, blood monocytes differentiate to macrophages in the presence of growth factors, such as macrophage colony-stimulation factor (M-CSF), and chemokines, such as platelet factor 4 (CXCL4). To compare the gene expression signa
Publikováno v:
Annals of the New York Academy of Sciences. 1148:269-281
Mammalian stress responses present a case study for investigating alternative splicing reactions in general, and changes in acetylcholinesterase (AChE) gene expression in particular, under endangered homeostasis. Acetylcholine (ACh) is a major regula
Autor:
Robert Tacke, Grzegorz Chodaczek, Shahram Salek-Ardakani, Helena Shaked, Amit Bar-Or, Minna U. Kaikkonen, Catherine C. Hedrick, Susan Togher, George Tweet, Alp Bugra Basat, Ayman Rezk, Christopher K. Glass, Graham D. Thomas, Amy Blatchley, Richard N. Hanna, Zbigniew Mikulski, Hozefa S. Bandukwala, Martin Darvas, Sonia Lai-Wing-Sun, Jacqueline Miller, Iftach Shaked, Heba Nowyhed
Publikováno v:
Nature immunology. 16(12)
The molecular mechanisms that link the sympathetic stress response and inflammation remain obscure. Here we found that the transcription factor Nr4a1 regulated the production of norepinephrine (NE) in macrophages and thereby limited experimental auto
Autor:
Sharon, Bakalash, Gil, Ben-Shlomo, Gil Ben, Shlomo, Eyal, Aloni, Iftach, Shaked, Larry, Wheeler, Ron, Ofri, Michal, Schwartz
Publikováno v:
Journal of Molecular Medicine. 83:904-916
Acute or chronic glaucoma is often associated with an increase in intraocular pressure (IOP). In many patients, however, therapeutic pressure reduction does not halt disease progression. Neuroprotection has been proposed as a complementary therapeuti