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pro vyhledávání: '"Ifi202"'
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Autor:
Roberto Baccala, Katarina M. Haraldsson, Timothy A. Stewart, Marie-Laure Santiago-Raber, Dwight H. Kono, Divaker Choubey, Argyrios N. Theofilopoulos
Publikováno v:
The Journal of Experimental Medicine
Indirect evidence suggests that type-I interferons (IFN-α/β) play a significant role in the pathogenesis of lupus. To directly examine the contribution of these pleiotropic molecules, we created congenic NZB mice lacking the α-chain of IFN-α/βR,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caa97239a60c905217ef9ee37ee7c1f8
https://doi.org/10.1084/jem.20021996
https://doi.org/10.1084/jem.20021996
Autor:
Hongzhu Liu, Xin Duan, Ravichandran Panchanathan, Muthuvel Arumugam, Divaker Choubey, Hui Shen
Publikováno v:
Molecular Immunology. 49:273-280
Upon sensing cytosolic double-stranded DNA (dsDNA), the murine Aim2 (encoded by the Aim2 gene) protein forms an inflammasome and promotes the secretion of proinflammatory cytokines, such as IL-1β and IL-18. In contrast, the p202 protein (encoded by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c6539fa9617666a7b71e4dffb49488f
https://doi.org/10.1016/j.molimm.2011.08.022
https://doi.org/10.1016/j.molimm.2011.08.022
Autor:
Xin Duan, Katherine A. Fitzgerald, Loren D. Erickson, Hui Shen, Ravichandran Panchanathan, Divaker Choubey, Vijay A. K. Rathinam
Publikováno v:
The Journal of Immunology. 186:6762-6770
Murine Aim2 and Ifi202 genes (encoding for the Aim2 and p202 proteins) are members of the IFN-inducible Ifi200 gene family. The Aim2 deficiency in mice activates IFN signaling and stimulates the expression of the lupus susceptibility gene, the Ifi202
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49fe4c4938077655f0af408fb6c24994
https://doi.org/10.4049/jimmunol.1003638
https://doi.org/10.4049/jimmunol.1003638
Autor:
Nobuya Sasaki, Akihiro Kamikawa, Yoshiharu Hashimoto, Daiji Endoh, Yasuhiro Kon, Saori Otsuka, Osamu Ichii
Publikováno v:
Lupus. 19(8):897-905
B6.MRLc1(82—100) congenic mice carrying the telomeric region of lupus-prone MRL chromosome 1 develop autoimmune glomerulonephritis (GN). The GN susceptibility locus of B6.MRLc1(82—100) contains the interferon activated gene 200 (Ifi200) family, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95f53f422f2e7fd4f9505d0815dfbe2e
http://hdl.handle.net/2115/46758
http://hdl.handle.net/2115/46758
Autor:
Lin Ma, Edward M. Schwarz, Kofi A. Mensah, Christopher T. Ritchlin, Alexis Mathian, Lianping Xing
Publikováno v:
Arthritis & Rheumatism. 62:1127-1137
Inflammatory arthritis is one of the most common clinical features in autoimmune disorders (1), and radiologic evidence of joint damage (erosions and joint space narrowing), is observed in almost all patients with rheumatoid arthritis (RA) followed f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa8dc98b065110a946ed95bc8750aff8
https://doi.org/10.1002/art.27312
https://doi.org/10.1002/art.27312
Autor:
Troy E. Metzger, Chao Jiang, Stephanie Atencio, Christina M. Mailloux, Hilda L. Enriquez, Loren D. Erickson, María Rosa Bono, Trine N. Jørgensen, William M. Loo, Jennifer Alfaro, Mario Rosemblatt, Brian L. Kotzin, Shannon Flannery, Stephen J. Rozzo, Melanie R. Gubbels Bupp
Publikováno v:
JOURNAL OF IMMUNOLOGY
Artículos CONICYT
CONICYT Chile
instacron:CONICYT
Artículos CONICYT
CONICYT Chile
instacron:CONICYT
Autoantibodies are of central importance in the pathogenesis of Ab-mediated autoimmune disorders. The murine lupus susceptibility locus Nba2 on chromosome 1 and the syntenic human locus are associated with a loss of immune tolerance that leads to ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35f764fd65c80285798074a6f585fe15
https://doi.org/10.4049/jimmunol.0901322
https://doi.org/10.4049/jimmunol.0901322
Publikováno v:
Immunology Letters. 119:32-41
Systemic lupus erythematosus (SLE) is the prototype of complex autoimmune diseases. Studies have suggested that genetic, hormonal, and environmental factors contribute to the development of the disease. Interestingly, several recent studies involving
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d82e176d4a187f2bf2124e1403295a1
https://doi.org/10.1016/j.imlet.2008.06.001
https://doi.org/10.1016/j.imlet.2008.06.001
Autor:
Bernard J Morley, SJ Rose, Stuart Horswell, G Fu, Mark Walport, Michelle E. K. Haywood, MJ Lees
Publikováno v:
Genes & Immunity. 7:250-263
The BXSB mouse strain is an important model of glomerulonephritis observed in systemic lupus erythematosus (SLE). Linkage studies have successfully identified disease-susceptibility intervals; however, extracting the identity of the susceptibility ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::177d56daccb3e8f76e2ed0a6d1365241
https://doi.org/10.1038/sj.gene.6364294
https://doi.org/10.1038/sj.gene.6364294
Publikováno v:
Journal of Biological Chemistry. 279:16121-16127
Systemic lupus erythematosus (SLE) is a prototype autoimmune disease. In human SLE patients, as well as in mouse models of SLE, the development of disease is associated with increased levels of pro-inflammatory cytokines, such as interleukin-6 (IL-6)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97f0af05fd08f93dda02c1ef771a035d
https://doi.org/10.1074/jbc.m313140200
https://doi.org/10.1074/jbc.m313140200