Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Ifeoma Okwor"'
Autor:
Lianyu Shan, Mojdeh Matloubi, Ifeoma Okwor, Sam Kung, Mohamed Sadek Almiski, Sujata Basu, Andrew Halayko, Latifa Koussih, Abdelilah S Gounni
Publikováno v:
PLoS ONE, Vol 19, Iss 8, p e0309868 (2024)
Dendritic cells (DCs) are pivotal in regulating allergic asthma. Our research has shown that the absence of Sema3E worsens asthma symptoms in acute and chronic asthma models. However, the specific role of PlexinD1 in these processes, particularly in
Externí odkaz:
https://doaj.org/article/2f0cab41bf624d9d9c70bd1042d48553
Autor:
Chukwunonso Onyilagha, Ping Jia, Nipun Jayachandran, Sen Hou, Ifeoma Okwor, Shiby Kuriakose, Aaron Marshall, Jude E Uzonna
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 9, Iss 4, p e0003716 (2015)
BACKGROUND:Bam32, a 32 kDa adaptor molecule, plays important role in B cell receptor signalling, T cell receptor signalling and antibody affinity maturation in germinal centres. Since antibodies against trypanosome variant surface glycoproteins (VSG)
Externí odkaz:
https://doaj.org/article/e8ed02194b374b06ae610fcb26a22859
Publikováno v:
PLoS Pathogens, Vol 10, Iss 9, p e1004396 (2014)
Although it is generally believed that CD4(+) T cells play important roles in anti-Leishmania immunity, some studies suggest that they may be dispensable, and that MHC II-restricted CD3(+)CD4(-)CD8(-) (double negative, DN) T cells may be more importa
Externí odkaz:
https://doaj.org/article/df4ae6c1ef3a4899a06dc113125fab3d
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e66058 (2013)
Despite inducing very low IFN-γ response and highly attenuated in vivo, infection of mice with phosphoglycan (PG) deficient Leishmania major (lpg2-) induces protection against virulent L. major challenge. Here, we show that mice infected with lpg2-
Externí odkaz:
https://doaj.org/article/f37a1bae26814e27baa199e3fc305ebe
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 6, Iss 7, p e1761 (2012)
BACKGROUND: BALB/c mice are highly susceptible while C57BL/6 are relatively resistant to experimental Trypanosoma congolense infection. Although regulatory T cells (Tregs) have been shown to regulate the pathogenesis of experimental T. congolense inf
Externí odkaz:
https://doaj.org/article/fa87cf5d24d445edbba18c71052cfd00
Autor:
Ashfaque Mohammed, Ifeoma Okwor, Chukwunonso Onyilagha, Jude E. Uzonna, Abdelilah S. Gounni, Lianyu Shan
Publikováno v:
The Journal of Immunology. 204:128-136
Semaphorin 3E (Sema3E) is a secreted protein that was initially discovered as a neuronal guidance cue. Recent evidence showed that Sema3E plays an essential role in regulating the activities of various immune cells. However, the exact role of Sema3E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::039afe1140c4b59cd13c1e06df717c4b
https://doi.org/10.4049/jimmunol.1801514
https://doi.org/10.4049/jimmunol.1801514
Autor:
Amena Aktar, Lianyu Shan, Latifa Koussih, Mohamed S. Almiski, Sujata Basu, Andrew Halayko, Ifeoma Okwor, Jude E. Uzonna, Abdelilah S. Gounni
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 208(5)
Interstitial macrophages (IMs) are key regulators of allergic inflammation. We previously showed that the absence of semaphorin 3E (Sema3E) exacerbates asthma features in both acute and chronic asthma models. However, it has not been studied whether
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc73785038cafcc131670d507985b497
https://pubmed.ncbi.nlm.nih.gov/35110420
https://pubmed.ncbi.nlm.nih.gov/35110420
Autor:
Olivia C. Ihedioha, Jyoti Balhara, Jude E. Uzonna, Anne Blanchard, Yvonne Myal, Ping Jia, Ifeoma Okwor
Publikováno v:
Immunologic Research. 66:245-254
The prolactin-inducible protein (PIP) is considered a valuable biomarker that is associated with both benign and malignant pathological conditions of the mammary gland. The function of PIP in breast tumorigenesis remains unknown; however, evidence fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28cd5bf9c792086ea1561c946719eca7
https://doi.org/10.1007/s12026-018-8987-6
https://doi.org/10.1007/s12026-018-8987-6
Autor:
Jude E. Uzonna, Ifeoma Okwor
Publikováno v:
Cellular Immunology. 309:32-36
Leishmaniasis affects millions of people worldwide and continues to pose public health problem. There is extensive evidence supporting the critical role for IL-12 in initiating and maintaining protective immune response to Leishmania infection. Altho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::544714560df79a36265f4a2e900e23c5
https://doi.org/10.1016/j.cellimm.2016.06.004
https://doi.org/10.1016/j.cellimm.2016.06.004
Publikováno v:
The Journal of Immunology. 193:655-662
Regulatory T cells (Tregs) are essential for maintenance of peripheral tolerance, and defects in Treg function have been linked to several autoimmune diseases. We previously reported that depletion of Tregs resulted in mortality to an otherwise nonle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80afcf3585896168150225e19388d410
https://doi.org/10.4049/jimmunol.1303064
https://doi.org/10.4049/jimmunol.1303064