Výsledky vyhledávání - "Ievgen Motorykin"

Monitoring and Identifying Insulin-Like Growth Factor 1 Variants by Liquid Chromatography-High-Resolution Mass Spectrometry in a Clinical Laboratory

Autor: Ievgen, Motorykin, Allison, Li, Zengru, Wu

Publikováno v: Methods in molecular biology (Clifton, N.J.). 2546

Protein and peptide hormones often exist as sequence variants with different molecular mass. Monitoring these variants of different molecular mass by mass spectrometry using mass-to-charge (m/z) ratio that is indicative of the wild type may lead to i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::27e16f52a6513d9eaf6c0d488e71ad37
https://pubmed.ncbi.nlm.nih.gov/36127594

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Isotopic Peak Index, Relative Retention Time, and Tandem MS for Automated High Throughput IGF-1 Variants Identification in a Clinical Laboratory

Autor: Nigel J. Clarke, Michael J. McPhaul, Zengru Wu, Hua Li, Ievgen Motorykin

Publikováno v: Analytical chemistry. 93(34)

Measuring insulin-like growth factor-1 (IGF-1) is useful for assessing and managing growth-related disorders, such as acromegaly and growth hormone deficiency. High-resolution liquid chromatography-mass spectrometry (LC-MS) is used for measuring IGF-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6d96dc84410e3544e7d487972746229
https://pubmed.ncbi.nlm.nih.gov/34461729

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MON-271 Identification of IGF-1 Variants in a Clinical Study of 307,000 Specimens: Discrepancies with General Population and Novel Discoveries

Autor: Nigel J. Clarke, Ievgen Motorykin, Michael J. McPhaul, Zengru Wu

Publikováno v: Journal of the Endocrine Society

High resolution accurate mass (HRAM) mass spectrometry (MS) is a highly specific and robust method for identifying and quantifying intact IGF-1. However, protein variants with mass-to-charge ratios differing from wild type (WT) are not included in qu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92b8d1951f1b03f9f7ede51a3c222303
http://europepmc.org/articles/PMC7208636

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MaXLinker: Proteome-wide Cross-link Identifications with High Specificity and Sensitivity

Autor: Kumar Yugandhar, Haiyuan Yu, Marcus B. Smolka, Elnur Elyar Shayhidin, Michael Charles Lanz, Alden King-Yung Leung, Ievgen Motorykin, Sheng Zhang, Ting-Yi Wang, Jin Liang

Publikováno v: Mol Cell Proteomics

Protein-protein interactions play a vital role in nearly all cellular functions. Hence, understanding their interaction patterns and three-dimensional structural conformations can provide crucial insights about various biological processes and underl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d2b0eaaa65343653731452f49269b95
https://pubmed.ncbi.nlm.nih.gov/31839598

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Detection of Insulin-Like Growth Factor 1 Variants by Mass Spectrometry: Results from a Clinical Reference Laboratory

Autor: Michael J. McPhaul, Zengru Wu, Heather R. Sanders, Ievgen Motorykin, Michael P. Caulfield

Publikováno v: Clinical chemistry. 65(8)

To the Editor: In 2011, Bystrom et al. developed a top-down liquid chromatography–high-resolution mass spectrometry (LC-HRMS)1 assay for insulin-like growth factor 1 (IGF-1) quantification (1). Using a similar method, Hines et al. subsequently repo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65a73d03af5597958747aee995d797fe
https://pubmed.ncbi.nlm.nih.gov/31235536

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MON-487 Simultaneous Monitoring of 13 IGF-1 Variants in a Clinical Mass Spectrometry Assay

Autor: Michael J. McPhaul, Michael P. Caulfield, Zengru Wu, Ievgen Motorykin

Publikováno v: Journal of the Endocrine Society

In the clinical laboratory, identification and quantification of intact proteins by high resolution accurate mass (HRAM) mass spectrometry (MS) is a highly specific and robust technique. However, protein variants with mass-to-charge ratios (m/z) diff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43a43e06be9b7a3ea558f619ac0b603d
https://doi.org/10.1210/js.2019-mon-487

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Integrated proteomic and metabolomic analysis suggests high rates of glycolysis are likely required to support high carotenoid accumulation in banana pulp

Autor: Wenjie Huang, Shijuan Yan, Ganjun Yi, Sheng Zhang, Alisdair R. Fernie, Qian Kong, Ou Sheng, Ievgen Motorykin, Zhou Heng

Publikováno v: Food Chemistry

To gain a better understanding concerning factors underlying carotenoid metabolism in banana pulp we investigated the carotenoid profile, metabolome, proteome and relative expression levels of carotegenesis-associated genes of fruit pulp in the two b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::633878b09619258e65727e3357d907d6
https://hdl.handle.net/21.11116/0000-0003-E6F5-5

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IRE1α-XBP1 controls T cell function in ovarian cancer by regulating mitochondrial activity

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Tumours evade immune control by creating hostile microenvironments that perturb T cell metabolism and effector function 1?4 . However, it remains unclear how intra-tumoral T cells integrate and interpret metabolic stress signals. Here we report that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6620245ee9b2eb8349a1fc16f794b211
https://pubmed.ncbi.nlm.nih.gov/30517892

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