Výsledky vyhledávání - "Ieva Stirblyte"

Akademický článek

iPSC-Derived Platelets Depleted of HLA Class I Are Inert to Anti-HLA Class I and Natural Killer Cell Immunity

Autor: Daisuke Suzuki, Charlotte Flahou, Norihide Yoshikawa, Ieva Stirblyte, Yoshikazu Hayashi, Akira Sawaguchi, Marina Akasaka, Sou Nakamura, Natsumi Higashi, Huaigeng Xu, Takuya Matsumoto, Kosuke Fujio, Markus G. Manz, Akitsu Hotta, Hitoshi Takizawa, Koji Eto, Naoshi Sugimoto

Publikováno v: Stem Cell Reports, Vol 14, Iss 1, Pp 49-59 (2020)

Summary: The ex vivo production of platelets depleted of human leukocyte antigen class I (HLA-I) could serve as a universal measure to overcome platelet transfusion refractoriness caused by HLA-I incompatibility. Here, we developed human induced plur

Externí odkaz: https://doaj.org/article/9f437e1b02f6488582832358c907a1bf

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iPSC-Derived Platelets Depleted of HLA Class I Are Inert to Anti-HLA Class I and Natural Killer Cell Immunity

Autor: Natsumi Higashi, Yoshikazu Hayashi, Akitsu Hotta, Kosuke Fujio, Hitoshi Takizawa, Koji Eto, Markus G. Manz, Marina Akasaka, Charlotte Flahou, Huaigeng Xu, Takuya Matsumoto, Sou Nakamura, Daisuke Suzuki, Norihide Yoshikawa, Naoshi Sugimoto, Ieva Stirblyte, Akira Sawaguchi

Publikováno v: Stem Cell Reports, Vol 14, Iss 1, Pp 49-59 (2020)
Stem Cell Reports

Summary The ex vivo production of platelets depleted of human leukocyte antigen class I (HLA-I) could serve as a universal measure to overcome platelet transfusion refractoriness caused by HLA-I incompatibility. Here, we developed human induced pluri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72d31e2a5eb0ae00a52465f0d6628715
https://doi.org/10.5167/uzh-180152

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Belinostat, a potent HDACi, exerts antileukemic effect in human acute promyelocytic leukemia cells via chromatin remodelling

Autor: Ruta Navakauskiene, Giedre Valiuliene, Ieva Stirblyte, Mindaugas Valius, Dovile Cicenaite, Algirdas Kaupinis

Publikováno v: Journal of cellular and molecular medicine, Oxford : Wiley-Blackwell Publishing Ltd., 2015, vol. 19, no. 7, p. 1742-1755
Journal of Cellular and Molecular Medicine

Epigenetic changes play a significant role in leukaemia pathogenesis, therefore histone deacetylases (HDACis) are widely accepted as an attractive strategy for acute promyelocytic leukaemia (APL) treatment. Belinostat (Bel, PXD101), a hydroxamate-typ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96f0e5cd25dc620cf3e762f89149878d
https://repository.vu.lt/VU:ELABAPDB13940727&prefLang=en_US

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Epigenetic and molecular mechanisms underlying the antileukemic activity of the histone deacetylase inhibitor belinostat in human acute promyelocytic leukemia cells

Autor: Giedre Valiuliene, Ruta Navakauskiene, Grazina Treigyte, Jurate Savickiene, Ieva Stirblyte

Publikováno v: Anti-cancer drugs. 25(8)

Therapeutic strategies targeting histone deacetylase (HDAC) inhibition have become promising in many human malignancies. Belinostat (PXD101) is a hydroxamate-type HDAC inhibitor tested in phase I and II clinical trials in solid tumors and hematologic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78da419d5f74b2640b6d581960d1311a
https://pubmed.ncbi.nlm.nih.gov/24800886

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Euchromatic histone methyltransferase 2 inhibitor, BIX-01294, sensitizes human promyelocytic leukemia HL-60 and NB4 cells to growth inhibition and differentiation

Autor: Ieva Stirblyte, Jurate Savickiene, Ruta Navakauskiene, Giedre Valiuliene, Grazina Treigyte

Publikováno v: Leukemia research. 38(7)

The involvement of histone lysine methyltransferases (HMT) in carcinogenesis is not well understood. Here, we describe a dose-dependent growth and survival inhibitory effects of BIX-01294, a specific inhibitor of euchromatic HMT2, in promyelocytic le

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab879752f136e45c34bb5268978f7365
https://pubmed.ncbi.nlm.nih.gov/24832370

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