Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Ietje Kathmann"'
Autor:
Godefridus J. Peters, Ietje Kathmann, Elisa Giovannetti, Kees Smid, Yehuda G. Assaraf, Gerrit Jansen
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
BackgroundL-Leucovorin (l-LV; 5-formyltetrahydrofolate, folinic acid) is a precursor for 5,10-methylenetetrahydrofolate (5,10-CH2-THF), which is important for the potentiation of the antitumor activity of 5-fluorouracil (5FU). LV is also used to resc
Externí odkaz:
https://doaj.org/article/f181d697131a47c99e405f990bc122f8
Autor:
Godefridus J. Peters, Frank P. A. van Gemert, Ietje Kathmann, Guru Reddy, Saskia A. G. M. Cillessen, Gerrit Jansen
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Pralatrexate (Folotyn; PLX) and belinostat (Beleodaq; BLS) are registered for the treatment of patients with peripheral T-cell lymphoma (PTCL) and are being considered for other lymphomas. In this study we investigated whether BLS had the ability to
Externí odkaz:
https://doaj.org/article/3e3291e8ac454216bc476996dc1f37dc
Publikováno v:
ADMET and DMPK, Vol 6, Iss 3, Pp 258-266 (2018)
Protein tyrosine kinases form an important target for a new class of anticancer drugs, the tyrosine kinase inhibitors (TKIs). Recently we demonstrated that sunitinib, an inhibitor of the membrane-associated vascular endothelial growth factor receptor
Externí odkaz:
https://doaj.org/article/08cae2bdaf1e49888dda2235cec4051d
Autor:
Richard J. Honeywell, Ietje Kathmann, Elisa Giovannetti, Carmelo Tibaldi, Egbert F. Smit, Maria N. Rovithi, Henk M.W. Verheul, Godefridus J. Peters
Publikováno v:
Cancers, Vol 12, Iss 11, p 3322 (2020)
Background: tyrosine kinase inhibitors (TKIs) inhibit phosphorylation of signaling proteins. TKIs often show large variations in the clinic due to poor pharmacology, possibly leading to resistance. We compared gut absorption of inhibitors of epiderma
Externí odkaz:
https://doaj.org/article/c64ca7a182124f588213d5b3d615e9f8
Publikováno v:
ADMET and DMPK, Vol 4, Iss 1, Pp 23-34 (2016)
Transport of erlotinib, gefitinib, sorafenib, sunitinib, dasatinib and crizotinib can be active or passive, which was studied by measuring uptake at low (4 °C; passive) and normal temperature (37 °C; active and passive) and by the use of specific o
Externí odkaz:
https://doaj.org/article/6c3a768b03e04cff9faeccdeadf49389
Autor:
Dzjemma Sarkisjan, Joris R. Julsing, Btissame El Hassouni, Richard J. Honeywell, Ietje Kathmann, Larry H. Matherly, Young B. Lee, Deog J. Kim, Godefridus J. Peters
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 8, p 2717 (2020)
(1) Background: RX-3117 (fluorocyclopentenyl-cytosine) is a cytidine analog that inhibits DNA methyltransferase 1 (DNMT1). We investigated the mechanism and potential of RX-3117 as a demethylating agent in several in vitro models. (2) Methods: we use
Externí odkaz:
https://doaj.org/article/68b4de910bbf4c838cb3c06a99ffccf7
Autor:
Larry H. Matherly, Young Bok Lee, Joris R. Julsing, Dzjemma Sarkisjan, Btissame El Hassouni, Godefridus J. Peters, Deog Joong Kim, Ietje Kathmann, Richard J. Honeywell
Publikováno v:
Sarkisjan, D, Julsing, J R, El Hassouni, B, Honeywell, R J, Kathmann, I, Matherly, L H, Lee, Y B, Kim, D J & Peters, G J 2020, ' Rx-3117 (Fluorocyclopentenyl-cytosine)-mediated down-regulation of dna methyltransferase 1 leads to protein expression of tumor-suppressor genes and increased functionality of the proton-coupled folate carrier ', International Journal of Molecular Sciences, vol. 21, no. 8, 2717 . https://doi.org/10.3390/ijms21082717
International Journal of Molecular Sciences
Volume 21
Issue 8
International Journal of Molecular Sciences, 21(8):2717. Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences, Vol 21, Iss 2717, p 2717 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 8
International Journal of Molecular Sciences, 21(8):2717. Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences, Vol 21, Iss 2717, p 2717 (2020)
(1) Background: RX-3117 (fluorocyclopentenyl-cytosine) is a cytidine analog that inhibits DNA methyltransferase 1 (DNMT1). We investigated the mechanism and potential of RX-3117 as a demethylating agent in several in vitro models. (2) Methods: we use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a0b844558a3fc411cacfcb3190c8d10
https://research.vumc.nl/en/publications/038cd18b-dcaa-4848-94b5-1a8098b9efcb
https://research.vumc.nl/en/publications/038cd18b-dcaa-4848-94b5-1a8098b9efcb
Autor:
Daniel S. K. Liu, Patrick Pauwels, René J. P. Musters, Nele Van Der Steen, Adam E Frampton, Elisa Giovannetti, Godefridus J. Peters, Kaylee Keller, Rob Ruijtenbeek, Ietje Kathmann, Richard Honeywell, Johan Van Meerloo, Christian Rolfo, Henk Dekker, Letizia Porcelli
Publikováno v:
Journal of cellular physiology
Van Der Steen, N, Keller, K, Dekker, H, Porcelli, L, Honeywell, R J, Van Meerloo, J, Musters, R J P, Kathmann, I, Frampton, A E, Liu, D S K, Ruijtenbeek, R, Rolfo, C, Pauwels, P, Giovannetti, E & Peters, G J 2020, ' Crizotinib sensitizes the erlotinib resistant HCC827GR5 cell line by influencing lysosomal function ', Journal of Cellular Physiology, vol. 235, no. 11, pp. 8085-8097 . https://doi.org/10.1002/jcp.29463
Journal of Cellular Physiology
Journal of Cellular Physiology, 235(11), 8085-8097. Wiley-Liss Inc.
Van Der Steen, N, Keller, K, Dekker, H, Porcelli, L, Honeywell, R J, Van Meerloo, J, Musters, R J P, Kathmann, I, Frampton, A E, Liu, D S K, Ruijtenbeek, R, Rolfo, C, Pauwels, P, Giovannetti, E & Peters, G J 2020, ' Crizotinib sensitizes the erlotinib resistant HCC827GR5 cell line by influencing lysosomal function ', Journal of Cellular Physiology, vol. 235, no. 11, pp. 8085-8097 . https://doi.org/10.1002/jcp.29463
Journal of Cellular Physiology
Journal of Cellular Physiology, 235(11), 8085-8097. Wiley-Liss Inc.
In non‐small cell lung cancer, sensitizing mutations in epidermal growth factor receptor (EGFR) or cMET amplification serve as good biomarkers for targeted therapies against EGFR or cMET, respectively. Here we aimed to determine how this different
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e3cb5e46fce5225b712943810246a9b
http://hdl.handle.net/10044/1/83793
http://hdl.handle.net/10044/1/83793
Autor:
Egbert F. Smit, Elisa Giovannetti, Richard J. Honeywell, Ietje Kathmann, Henk M.W. Verheul, Carmelo Tibaldi, Maria Rovithi, Godefridus J. Peters
Publikováno v:
Cancers
Volume 12
Issue 11
Honeywell, R J, Kathmann, I, Giovannetti, E, Tibaldi, C, Smit, E F, Rovithi, M N, Verheul, H M W & Peters, G J 2020, ' Epithelial transfer of the tyrosine kinase inhibitors erlotinib, gefitinib, afatinib, crizotinib, sorafenib, sunitinib, and dasatinib: Implications for clinical resistance ', Cancers, vol. 12, no. 11, 3322, pp. 1-18 . https://doi.org/10.3390/cancers12113322
Cancers, 12(11):3322, 1-18. Multidisciplinary Digital Publishing Institute (MDPI)
Cancers, 12
Cancers, 12, 11
Cancers, Vol 12, Iss 3322, p 3322 (2020)
Cancers, 12(11). MDPI
Volume 12
Issue 11
Honeywell, R J, Kathmann, I, Giovannetti, E, Tibaldi, C, Smit, E F, Rovithi, M N, Verheul, H M W & Peters, G J 2020, ' Epithelial transfer of the tyrosine kinase inhibitors erlotinib, gefitinib, afatinib, crizotinib, sorafenib, sunitinib, and dasatinib: Implications for clinical resistance ', Cancers, vol. 12, no. 11, 3322, pp. 1-18 . https://doi.org/10.3390/cancers12113322
Cancers, 12(11):3322, 1-18. Multidisciplinary Digital Publishing Institute (MDPI)
Cancers, 12
Cancers, 12, 11
Cancers, Vol 12, Iss 3322, p 3322 (2020)
Cancers, 12(11). MDPI
Background: tyrosine kinase inhibitors (TKIs) inhibit phosphorylation of signaling proteins. TKIs often show large variations in the clinic due to poor pharmacology, possibly leading to resistance. We compared gut absorption of inhibitors of epiderma
Autor:
Godefridus J. Peters, Michael H. Kristensen, Richard J. Honeywell, Dzjemma Sarkisjan, Ietje Kathmann
Publikováno v:
Honeywell, R J, Sarkisjan, D, Kathmann, I, Kristensen, M H & Peters, G J 2016, ' Sensitive liquid chromatography mass spectrometry (LC-MS) assay reveals novel insights on DNA methylation and incorporation of gemcitabine, its metabolite difluorodeoxyuridine, deoxyuridine, and RX-3117 into DNA ', Nucleosides, Nucleotides and Nucleic Acids, vol. 35, no. 10-12, pp. 652-662 . https://doi.org/10.1080/15257770.2016.1216566
Nucleosides, Nucleotides and Nucleic Acids, 35(10-12), 652-662. Taylor and Francis Ltd.
Nucleosides, Nucleotides and Nucleic Acids, 35(10-12), 652-662. Taylor and Francis Ltd.
Antimetabolites are incorporated into DNA and RNA, affecting their function. Liquid-chromatography-mass-spectrometry (LC-MS-MS) permits the sensitive, selective analysis of normal nucleosides. The method was adapted to measure the incorporation of de