Zobrazeno 1 - 10
of 220
pro vyhledávání: '"Iekhsan Othman"'
Publikováno v:
Heliyon, Vol 10, Iss 17, Pp e37243- (2024)
Snake envenomation poses a significant risk to Malaysians and country visitors. Malaysia witnesses an estimated 650 snake bites per 100,000 population annually. The primary treatment for snake envenomation involves administering antivenom derived fro
Externí odkaz:
https://doaj.org/article/8d726433aa564241b9f0cc2c59a397aa
Publikováno v:
F1000Research, Vol 13 (2024)
Abstract* Epilepsy affects millions of people worldwide, and there is an urgent need to develop safe and effective therapeutic agents. Animal venoms contain diverse bioactive compounds like proteins, peptides, and small molecules, which may possess m
Externí odkaz:
https://doaj.org/article/cf353a1b5b7548dfa974de4647d5d868
Autor:
Sareshma Sudhesh Dev, Reyhaneh Farghadani, Syafiq Asnawi Zainal Abidin, Iekhsan Othman, Rakesh Naidu
Publikováno v:
Journal of Functional Foods, Vol 110, Iss , Pp 105845- (2023)
Flavonoids are polyphenolic compounds with promising anti-cancer properties, as well as low toxicity and high potency. Based on recent research, a potential mechanism of flavonoids appear to be via receptor tyrosine kinase (RTK) inhibition. RTKs are
Externí odkaz:
https://doaj.org/article/ed2832911c434fa0a5a9655a05166141
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 6, p 3503 (2024)
Diarylpentanoids are synthesized to overcome curcumin’s poor bioavailability and low stability to show enhanced anti-cancer effects. Little is known about the anti-cancer effects of diarylpentanoid MS17 (1,5-bis(2-hydroxyphenyl)-1,4-pentadiene-3-on
Externí odkaz:
https://doaj.org/article/0c43e223a00b422d9b0dfb33c077dce5
Autor:
Chanthawat Patikorn, Ahmad Khaldun Ismail, Syafiq Asnawi Zainal Abidin, Iekhsan Othman, Nathorn Chaiyakunapruk, Suthira Taychakhoonavudh
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 16, Iss 11, p e0010915 (2022)
BackgroundDespite domestic production of antivenoms in the Association of Southeast Asian Nations (ASEAN) countries, not all victims with snakebite envenomings indicated for antivenom received the appropriate or adequate effective dose of antivenom d
Externí odkaz:
https://doaj.org/article/e64fd9c9d6984793b39608bb3e021c4d
Autor:
Nur Atiqah Haizum Abdullah, Nur Qisya Afifah Veronica Sainik, Ezalia Esa, Nur Afrina Muhamad Hendri, Muhamad Rusdi Ahmad Rusmili, Wayne C. Hodgson, Mohd Farooq Shaikh, Iekhsan Othman
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Oxidative stress is one of the factors involved in the pathogenesis of several neurodegenerative diseases. It has been reported that a secretory phospholipase A2 known as A2-EPTX-NSm1a has lower cytotoxicity in neuronal cells compared to its crude Na
Externí odkaz:
https://doaj.org/article/908fd2b370bd4d568979e33f6b63e847
Autor:
Chanthawat Patikorn, Jörg Blessmann, Myat Thet Nwe, Patrick Joseph G Tiglao, Taksa Vasaruchapong, Tri Maharani, Uyen Vy Doan, Syafiq Asnawi Zainal Abidin, Ahmad Khaldun Ismail, Iekhsan Othman, Suthira Taychakhoonavudh, Nathorn Chaiyakunapruk
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 16, Iss 9, p e0010775 (2022)
BackgroundUnderstanding the burden of snakebite is crucial for developing evidence-informed strategies to pursue the goal set by the World Health Organization to halve morbidity and mortality of snakebite by 2030. However, there was no such informati
Externí odkaz:
https://doaj.org/article/476fc2d26de94b09bd04c0c8aca3daee
Autor:
Nik Syazana Izyan Saffery, Krishnamurithy Genasan, Chee Ken Chan, Khairul Anwar Ayob, Seow Hui Teo, Mohamed Zubair Mohamed Al-Fayyadh, Iekhsan Othman, Syafiq Asnawi Zainal Abidin, Murali Malliga Raman, Hanumantha Rao Balaji Raghavendran, Tunku Kamarul
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
ObjectiveSynovitis with increased infiltration of immune cells is observed in osteoarthritis (OA). Given the inflammatory condition of synovitis, we explored the protein profile of OA synovium (OAS) and its effect on circulating monocytes activation,
Externí odkaz:
https://doaj.org/article/b88b19d3d4084fa4acdfcd2d4222fd81
Autor:
Ines Hilal, Soukaina Khourcha, Amal Safi, Abdelaziz Hmyene, Syafiq Asnawi, Iekhsan Othman, Reto Stöcklin, Naoual Oukkache
Publikováno v:
Life, Vol 13, Iss 5, p 1133 (2023)
Morocco is known to harbor two of the world’s most dangerous scorpion species: the black Androctonus mauritanicus (Am) and the yellow Buthus occitanus (Bo), responsible for 83% and 14% of severe envenomation cases, respectively. Scorpion venom is a
Externí odkaz:
https://doaj.org/article/bbf7662f0ae74ea89be3428e3aaf5aad
Autor:
Nor Asyikin Zukifli, Muhamad Rusdi Ahmad Rusmili, Iekhsan Othman, Ahmad Khaldun Ismail, Janeyuth Chaisakul, Zalikha Ibrahim
Publikováno v:
Journal of Pharmacy, Vol 2, Iss 2 (2022)
Introduction: Snake venom is a combination of various proteins and peptides that cause diverse biological effects on multiple organ systems. In elapid venom, three-finger toxins are the most abundant type of toxin. Although toxins share similarities
Externí odkaz:
https://doaj.org/article/9a2bd3c4179d468e9978ff8c8464d145