Zobrazeno 1 - 10
of 627
pro vyhledávání: '"Ie-Ming Shih"'
Autor:
Christine M. O'Keefe, Yang Zhao, Leslie M. Cope, Chih‐Ming Ho, Amanda N. Fader, Rebecca Stone, James S. Ferris, Anna Beavis, Kimberly Levinson, Stephanie Wethington, Tian‐Li Wang, Thomas R. Pisanic, Ie‐Ming Shih, Tza‐Huei Wang
Publikováno v:
Clinical and Translational Medicine, Vol 14, Iss 8, Pp n/a-n/a (2024)
Abstract Recent advances in molecular analyses of ovarian cancer have revealed a wealth of promising tumour‐specific biomarkers, including protein, DNA mutations and methylation; however, reliably detecting such alterations at satisfactorily high s
Externí odkaz:
https://doaj.org/article/9aace26585f240c7a1a7284b98330d63
Publikováno v:
Journal of Biomedical Science, Vol 30, Iss 1, Pp 1-14 (2023)
Abstract Background ARID1A, a tumor suppressor gene encoding BAF250, a protein participating in chromatin remodeling, is frequently mutated in endometrium-related malignancies, including ovarian or uterine clear cell carcinoma (CCC) and endometrioid
Externí odkaz:
https://doaj.org/article/f63aedcdc369458da128e915982fc096
Autor:
Ting-Wan Kao, Geng-Hao Bai, Tian-Li Wang, Ie-Ming Shih, Chi-Mu Chuang, Chun-Liang Lo, Meng-Chen Tsai, Li-Yun Chiu, Chu-Chien Lin, Yao-An Shen
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-35 (2023)
Abstract Chemotherapy, radiotherapy, targeted therapy, and immunotherapy are established cancer treatment modalities that are widely used due to their demonstrated efficacy against tumors and favorable safety profiles or tolerability. Nevertheless, t
Externí odkaz:
https://doaj.org/article/e9d8d5519a084a32a5cfaeca40c8f7cf
Autor:
Motoki Ono, Tsutomu Miyamoto, Ryoichi Asaka, Junko Uchikawa, Hirofumi Ando, Yasuhiro Tanaka, Manaka Shinagawa, Yusuke Yokokawa, Shiho Asaka, Tian-Li Wang, Ie-Ming Shih, Tanri Shiozawa
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract Although endometriosis is primarily benign, it has been identified as a risk factor for endometriosis-associated ovarian cancer (EAOC). Genetic alterations in ARID1A, PTEN, and PIK3CA have been reported in EAOC; however, an appropriate EAOC
Externí odkaz:
https://doaj.org/article/aa8c9295882642ffa4d2a7d7faf5c538
Autor:
Jiaxin Hong, Yao-An Shen, Chih-Yi Hsu, Peng Huang, Alicja Tomaszewski, Edward Gabrielson, Ie-Ming Shih, Stephanie Gaillard, Tian-Li Wang
Publikováno v:
Genes and Diseases, Vol 9, Iss 6, Pp 1408-1411 (2022)
Externí odkaz:
https://doaj.org/article/a60241a873224c5eadc89fffd55d9b97
Publikováno v:
Journal of Biomedical Science, Vol 29, Iss 1, Pp 1-15 (2022)
Abstract Chromatin remodeling is an essential cellular process for organizing chromatin structure into either open or close configuration at specific chromatin locations by orchestrating and modifying histone complexes. This task is responsible for f
Externí odkaz:
https://doaj.org/article/9202199521bf40349ffe0647f50304f4
Autor:
Yohan Suryo Rahmanto, Wenjing Shen, Xu Shi, Xi Chen, Yu Yu, Zheng-Cheng Yu, Tsutomu Miyamoto, Meng-Horng Lee, Vivek Singh, Ryoichi Asaka, Geoffrey Shimberg, Michele I. Vitolo, Stuart S. Martin, Denis Wirtz, Ronny Drapkin, Jianhua Xuan, Tian-Li Wang, Ie-Ming Shih
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
ARID1A, which is often mutated in human endometrial cancer, is a component of the SWI/SNF chromatin remodelling complex. Here, the authors show that Arid1a mutations in the mouse endometrium and primary human endometrial epithelial cells cause widesp
Externí odkaz:
https://doaj.org/article/75bea59380ee4facabb9a13db669ea7a
Autor:
Yao-An Shen, Jin Jung, Geoffrey D. Shimberg, Fang-Chi Hsu, Yohan Suryo Rahmanto, Stephanie L. Gaillard, Jiaxin Hong, Jürgen Bosch, Ie-Ming Shih, Chi-Mu Chuang, Tian-Li Wang
Publikováno v:
iScience, Vol 24, Iss 11, Pp 103297- (2021)
Summary: PBX1 is a transcription factor involved in diverse cellular functions including organ development, stem cell renewal, and tumorigenesis. PBX1 is localized at chr1q23.3, a frequently amplified chromosomal region, and it is overexpressed in ma
Externí odkaz:
https://doaj.org/article/8619e16c5d294c30acce63292715bdfb
Autor:
Angela L. Liang, Payam Katebi Kashi, Mark Hopkins, Anna Beavis, Stephanie Gaillard, Ie-Ming Shih, Amanda N. Fader
Publikováno v:
Gynecologic Oncology Reports, Vol 38, Iss , Pp 100877- (2021)
Externí odkaz:
https://doaj.org/article/b552a02edf054e729175459a59990e95
Autor:
Yu Yu, Yohan Suryo Rahmanto, Yao-An Shen, Laura Ardighieri, Ben Davidson, Stephanie Gaillard, Ayse Ayhan, Xu Shi, Jianhua Xuan, Tian-Li Wang, Ie-Ming Shih
Publikováno v:
EBioMedicine, Vol 47, Iss , Pp 184-194 (2019)
Background: Spleen tyrosine kinase (SYK) is frequently upregulated in recurrent ovarian carcinomas, for which effective therapy is urgently needed. SYK phosphorylates several substrates, but their translational implications remain unclear. Here, we s
Externí odkaz:
https://doaj.org/article/bee7cabc93c645bea57be3b17dc7add6