Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Idrees Mian"'
Autor:
Azam Ghafoor, MD, Idrees Mian, MD, Cathy Wagner, BSN, Yvonne Mallory, BSN, Maria Garcia Agra, BSN, Betsy Morrow, BS, Jun S. Wei, PhD, Javed Khan, MD, Anish Thomas, M.B.B.S., MD, Manjistha Sengupta, PhD, Seth M. Steinberg, PhD, Raffit Hassan, MD
Publikováno v:
JTO Clinical and Research Reports, Vol 2, Iss 10, Pp 100231- (2021)
Introduction: PARP inhibition may enhance antitumor responses in BAP1-associated mesothelioma by inducing synthetic lethality. Methods: A single-center, nonrandomized, phase 2 trial was conducted, in which patients with refractory mesothelioma were g
Externí odkaz:
https://doaj.org/article/d58aa11f4d9f4b56b290574901b887da
Autor:
Nishanth Ulhas Nair, Qun Jiang, Jun Stephen Wei, Vikram Alexander Misra, Betsy Morrow, Chimene Kesserwan, Leandro C. Hermida, Joo Sang Lee, Idrees Mian, Jingli Zhang, Alexandra Lebensohn, Manjistha Sengupta, Javed Khan, Eytan Ruppin, Raffit Hassan
Malignant mesothelioma is an aggressive cancer with limited treatment options and poor prognosis. Better understanding of mesothelioma genomics and transcriptomics could advance novel therapies. We performed whole-exome and RNA-sequencing of germline
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65fef15251110a80b617e7fa995ace7a
https://doi.org/10.1101/2022.04.13.488207
https://doi.org/10.1101/2022.04.13.488207
Autor:
Nishanth Ulhas Nair, Qun Jiang, Jun Stephen Wei, Vikram Alexander Misra, Betsy Morrow, Chimene Kesserwan, Leandro C. Hermida, Joo Sang Lee, Idrees Mian, Jingli Zhang, Alexandra Lebensohn, Markku Miettinen, Manjistha Sengupta, Javed Khan, Eytan Ruppin, Raffit Hassan
Publikováno v:
Cell Reports Medicine. 4:100938
Autor:
Siraj M. Ali, Junya Fujimoto, Elad Sharon, Garrett M. Frampton, Kathleen Maignan, Aracelis Z. Torres, Gerald Li, Ignacio I. Wistuba, Vinodh N. Rajapakse, Jeremy Snider, Eva Szabo, Camille Tlemsani, Nobuyuki Takahashi, Javed Khan, Samantha Nichols, Anish Thomas, Jun Wei, Se Hyun Kim, Kenneth R. Carson, Idrees Mian, Udayan Guha, Cesar A Moran, Lorinc Pongor
Publikováno v:
Chest. 158:1723-1733
Background Small cell lung cancer (SCLC) has the strongest association with smoking among lung cancers. The characteristics of never smokers with SCLC is not known. Research Question Are the clinical characteristics, prognostic factors, survival, gen
Autor:
Jean-Pierre Delord, Seth M. Steinberg, Anna Spreafico, Anish Thomas, Raffit Hassan, Rastilav Bahleda, Ira Pastan, Carlos Gomez-Roca, Cody J. Peer, Gerhard Niederfellner, Jean-Charles Soria, Christine Alewine, Lillian L. Siu, William D. Figg, Antoine Italiano, Ulrik Lassen, Valerie Meresse Naegelen, Idrees Mian
Publikováno v:
Cancer. 126:4936-4947
Background LMB-100 is an antibody-toxin conjugate with an antimesothelin Fab linked to a 24-kilodalton portion of Pseudomonas exotoxin A with mutations that decrease immunogenicity. The objective of the current first-in-human phase 1 study was to det
Autor:
Javed Khan, Betsy Morrow, David S. Schrump, Zied Abdullaev, Raffit Hassan, Idrees Mian, Rosandra N. Kaplan, Markku Miettinen, Jun S. Wei, Svetlana Pack, Shaojian Gao, Valerie Zgonc
Publikováno v:
Journal of Thoracic Oncology. 15:457-461
Introduction Children and young adults diagnosed with malignant mesothelioma may have unique genetic characteristics. In this study, we evaluated for the presence of the anaplastic lymphoma kinase (ALK) translocations in these patients. Methods In a
Autor:
Jun S. Wei, Maria Agra, Cathy Wagner, Seth M. Steinberg, Anish Thomas, Javed Khan, Azam Ghafoor, Betsy Morrow, Raffit Hassan, Manjistha Sengupta, Idrees Mian, Yvonne Mallory
Publikováno v:
JTO Clinical and Research Reports
JTO Clinical and Research Reports, Vol 2, Iss 10, Pp 100231-(2021)
JTO Clinical and Research Reports, Vol 2, Iss 10, Pp 100231-(2021)
Introduction PARP inhibition may enhance antitumor responses in BAP1-associated mesothelioma by inducing synthetic lethality. Methods A single-center, nonrandomized, phase 2 trial was conducted, in which patients with refractory mesothelioma were giv
Autor:
Betsy Morrow, Ming K. Lee, Jun Wei, Anish Thomas, Liqiang Xi, Raffit Hassan, Idrees Mian, Mary Claire King, Tom Walsh, Jingli Zhang, Snehal Patel, Vasiliki Panou, David S. Schrump, Jane E. Churpek, Arpita Desai, Mark Raffeld, Emerson Padiernos, Javed Khan, Meghana Gadiraju, Shaojian Gao, Kathleen A. Calzone, Mary Hesdorffer, Suleyman Gulsuner, Christine Alewine, Seth M. Steinberg, Hedy L. Kindler
Publikováno v:
Hassan, R, Morrow, B, Thomas, A, Walsh, T, Lee, M K, Gulsuner, S, Gadiraju, M, Panou, V, Gao, S, Mian, I, Khan, J, Raffeld, M, Patel, S, Xi, L, Wei, J S, Hesdorffer, M, Zhang, J, Calzone, K, Desai, A, Padiernos, E, Alewine, C, Schrump, D S, Steinberg, S M, Kindler, H L, King, M-C & Churpek, J E 2019, ' Inherited predisposition to malignant mesothelioma and overall survival following platinum chemotherapy ', Proceedings of the National Academy of Sciences of the United States of America, vol. 116, no. 18, pp. 9008-9013 . https://doi.org/10.1073/pnas.1821510116
Survival from malignant mesothelioma, particularly pleural mesothelioma, is very poor. For patients with breast, ovarian, or prostate cancers, overall survival is associated with increased sensitivity to platinum chemotherapy due to loss-of-function
Autor:
Anish, Thomas, Idrees, Mian, Camille, Tlemsani, Lorinc, Pongor, Nobuyuki, Takahashi, Kathleen, Maignan, Jeremy, Snider, Gerald, Li, Garrett, Frampton, Siraj, Ali, Sehyun, Kim, Samantha, Nichols, Vinodh, Rajapakse, Udayan, Guha, Elad, Sharon, Junya, Fujimoto, Cesar A, Moran, Ignacio I, Wistuba, Jun S, Wei, Javed, Khan, Eva, Szabo, Aracelis Z, Torres, Kenneth R, Carson
Publikováno v:
Chest
BACKGROUND: Small cell lung cancer (SCLC) has the strongest association with smoking among lung cancers. The characteristics of never smokers with SCLC is not known. RESEARCH QUESTION: Are the clinical characteristics, prognostic factors, survival, g
Autor:
Idrees Mian, Raffit Hassan, Manjistha Sengupta, Anish Thomas, Daniel Rathkey, Ira Pastan, Seth M. Steinberg, Jingli Zhang, Christine Alewine, Qun Jiang, Mark A. Ahlman, Betsy Morrow, Azam Ghafoor
Publikováno v:
Sci Transl Med
LMB-100 is an immunotoxin targeting the cell surface protein mesothelin, which is highly expressed in many cancers including mesothelioma. Having observed that patients receiving pembrolizumab off protocol after LMB-100 treatment had increased tumor